Candidemia in a public hospital in Northeastern Brazil: Epidemiological features and risk factors in critically ill patients

Silva, Renata Baltar da; Neves, Rejane Pereira; Hinrichsen, Sylvia Lemos; Lima-Neto, Reginaldo Gonçalves de

doi:10.1016/j.riam.2019.06.003

Cited by 12 publications

(12 citation statements)

References 25 publications

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“…A 2009 multi‐continent study of ICU patients from Australia, Europe and South America showed that non‐albicans Candida represented the majority of isolates only in South America 7 . Since then, more contemporary ICU studies have reaffirmed an albicans majority in Europe 8,9 and Australia, 5 but not in Asia 1 and not in South America 2,3 . All of the aforementioned studies included mixed ICU populations with varying neutropenic contingents, making direct correlation with our results challenging.…”

Section: Discussionmentioning

confidence: 66%

“…7 Since then, more contemporary ICU studies have reaffirmed an albicans majority in Europe 8,9 and Australia, 5 but not in Asia 1 and not in South America. 2,3 All of the aforementioned studies included mixed ICU populations with varying neutropenic contingents, making direct correlation with 3. 6,[10][11][12][13][14][15][16][17][18][19] As in our study, a non-albicans majority has been observed among COVID candidaemia isolates in another tertiary academic centre in the United States, 18 whereas an albicans majority was recorded across three Brazilian tertiary hospitals 17,19 as well as in the United Kingdom 16 and Italy.…”

Section: Re Sultsmentioning

confidence: 99%

“…While the importance of Candida as a pathogen in non‐neutropenic medical ICU patients has been increasingly recognised, studies restricted to this fundamental ICU population remain few. Among the features of IC rarely studied in this specific population is the relative distribution of albicans versus non‐albicans species among contemporary isolates, an issue of importance because some studies in undifferentiated ICU populations have suggested a shift from the traditional majority of the former to a majority of the latter 1‐3 …”

Section: Introductionmentioning

confidence: 99%

“…Among the features of IC rarely studied in this specific population is the relative distribution of albicans versus non-albicans species among contemporary isolates, an issue of importance because some studies in undifferentiated ICU populations have suggested a shift from the traditional majority of the former to a majority of the latter. [1][2][3] The ongoing pandemic of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which has created a global explosion in the number of critically ill patients with respiratory failure, has contributed an additional question: Has the pandemic changed the incidence, patient characteristics, and speciation of IC cases in medical ICUs? We performed the present analysis of our medical ICU non-oncological candidaemia cases in order to describe the epidemiology and mycology of IC in this population as well as to compare those with and without coronavirus disease 2019 (COVID).…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology and Mycology of Candidaemia in non‐oncological medical intensive care unit patients in a tertiary center in the United States: Overall analysis and comparison between non‐COVID‐19 and COVID‐19 cases

Macauley

Epelbaum

2021

Mycoses

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The epidemiology and mycology of invasive candidiasis in the ICU is well‐described in certain types of critically ill patients but not in others. One population that has been scarcely studied is non‐neutropenic patients admitted specifically to medical ICUs. Even less is known about the broader category of medical ICU patients without active oncological disease. This group constitutes a very large share of the patients requiring critical care across the globe, especially in the era of the SARS‐CoV‐2 pandemic. We analysed medical ICU candidaemia episodes that occurred in non‐oncological patients in our tertiary academic centre in the United States from May 2014 to October 2020 to determine the incidence and species distribution of the associated isolates. We then separately considered non‐COVID‐19 and COVID‐19 cases and compared their characteristics. In the non‐COVID‐19 group, there were 38 cases for an incidence of 1.1% and rate of 11/1000 admissions. In the COVID‐19 group, there were 12 cases for an incidence of 5.1% and rate of 51/1000 admissions. In the entire sample, as well as separately in the non‐COVID‐19 and COVID‐19 groups, Candida albicans accounted for a minority of isolates. Compared to non‐COVID‐19 patients with candidaemia, COVID‐19 patients had lower ICU admission SOFA score but longer ICU length of stay and central venous catheter dwell time at candidaemia detection. This study provides valuable insight into the incidence and species distribution of candidaemia cases occurring in non‐oncological critically ill patients and identifies informative differences between non‐COVID‐19 and COVID‐19 patients.

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Section: Discussionmentioning

confidence: 66%

Section: Re Sultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Epidemiology and Mycology of Candidaemia in non‐oncological medical intensive care unit patients in a tertiary center in the United States: Overall analysis and comparison between non‐COVID‐19 and COVID‐19 cases

Macauley

Epelbaum

2021

Mycoses

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“…Patients with diabetes mellitus were prone to invasive fungal infections [ 25 ]. The most common pathogens are A. fumigatus and C. albicans [ 26 , 27 ]. This is consistent with the results of our current study.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Clinical Utility of Metagenomic Next-Generation Sequencing in the Diagnosis of Pulmonary Infection

et al. 2021

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Introduction: We aimed to explore the realworld clinical application value and challenges of metagenomic next-generation sequencing (mNGS) for pulmonary infection diagnosis. Methods: We retrospectively reviewed the results of mNGS and conventional tests from 140 hospitalized patients with suspected pulmonary infections from January 2019 to December 2020. The sample types included bronchoalveolar lavage fluid, lung tissue by transbronchial lung biopsy, pleural effusion, blood, and bronchial sputum. Apart from the mNGS reports that our patients received, an Guijuan Xie and Bo Zhao contributed equally to this work.

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Production of IgY against iron permease Ftr1 from Candida albicans and evaluation of its antifungal activity using Galleria mellonella as a model of systemic infection

Souza

Corrêa

Gameiro

et al. 2023

Microbial Pathogenesis

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Candidemia in a public hospital in Northeastern Brazil: Epidemiological features and risk factors in critically ill patients

Cited by 12 publications

References 25 publications

Epidemiology and Mycology of Candidaemia in non‐oncological medical intensive care unit patients in a tertiary center in the United States: Overall analysis and comparison between non‐COVID‐19 and COVID‐19 cases

Epidemiology and Mycology of Candidaemia in non‐oncological medical intensive care unit patients in a tertiary center in the United States: Overall analysis and comparison between non‐COVID‐19 and COVID‐19 cases

Exploring the Clinical Utility of Metagenomic Next-Generation Sequencing in the Diagnosis of Pulmonary Infection

Production of IgY against iron permease Ftr1 from Candida albicans and evaluation of its antifungal activity using Galleria mellonella as a model of systemic infection

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