Candidate gene expression and intramuscular fat content in pigs

Serão, Nick V. L.; Veroneze, Renata; Ribeiro, André; Verardo, Lucas Lima; Neto, José Braccini; Gasparino, Eliane; Campos, Carolina; Lopes, Paulo Sávio; Guimarães, Simone Eliza Facioni

doi:10.1111/j.1439-0388.2010.00887.x

Cited by 65 publications

(49 citation statements)

References 21 publications

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“…Few studies have suggested that the association between the IMF content and tenderness might be deciphered by the fat cell expansion in the perimysium, which might open the muscle structure by forcing the muscle bundles apart (Wood, 1990). Recently, most of studies on IMF have focused on the mechanisms of lipogenesis (Morcuende et al, 2007;Zhao et al, 2009), and numerous candidate genes associated with IMF deposition had been identified (Cánovas et al, 2010;Serão et al, 2011;Tyra and Ropka-Molik, 2011), which may improve our ability to effectively enhance the IMF content in pork and other livestock.…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization and tissue expression profile analysis of the porcine JAZF1 gene

Yang¹,

He²,

Xu³

et al. 2015

Genet. Mol. Res.

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ABSTRACT.A recent study indicated that the JAZF1 gene was related to lipid metabolism by regulating the level of gene expression in humans and mice. In order to investigate whether JAZF1 gene expression was associated with fat deposition in pig, we cloned the full-coding region of the JAZF1 gene (GenBank accession No. KF307636) from porcine longissimus dorsi. Results showed that the open reading frame of JAZF1 covered 732 bp and encoded 243 amino acids. Multiple alignment of isoform sequences revealed that the deduced amino acid sequence of JAZF1 had a high degree of sequence similarity to other vertebrates, indicating that it was highly conserved during evolution. Bioinformatic analysis indicated that pig JAZF1 contained 23 phosphorylation sites and 19 glycosyl sites. JAZF1 was predicted to have 3 ZnF-C 2 H 2 and 2 low-complexity domains. The JAZF1 mRNA expression pattern indicated that JAZF1 mRNA expression level in the liver was significantly different in 2 divergent breeds (P < 0.05). This article perhaps provided an important experimental basis for further research on the mechanisms of lipid metabolism and fat deposition in pigs.

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Section: Discussionmentioning

confidence: 99%

Molecular characterization and tissue expression profile analysis of the porcine JAZF1 gene

Yang¹,

He²,

Xu³

et al. 2015

Genet. Mol. Res.

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“…This syndrome in humans is caused by heterozygous deletions of about 1.6 Mb, and one of the numerous symp- (Sasaki et al, 2006;Serao et al, 2011) 18 56 485 824-57 128 560 R PSMA2 negative correlation with male BMI (Sakamoto et al, 2009) toms in about 15 % of the cases is hypercalcemia (Cagle et al, 2004). Thus, at least one of the genes in this region must have an influence on blood calcium levels.…”

Section: Resultsmentioning

confidence: 99%

“…The decision about a possible candidate status was thus hindered. However, in 7 of the 10 remaining regions, possible candidate genes could be identified: WBSCR17 (International Mouse Phenotyping Consortium), SRSF7 (International Mouse Phenotyping Consortium), USP28 (Valero et al, 2001), NNMT (Trammell and Brenner, 2015), ZBED6 (Clark et al, 2015;Markljung et al, 2009), NMNAT2 (Hicks et al, 2012), ABHD6 (Thomas et al, 2013), PDHB (Sasaki et al, 2006;Serao et al, 2011) and PSMA2 (Sakamoto et al, 2009). These are listed in Table 2.…”

Section: Resultsmentioning

confidence: 99%

Genome-wide QTL mapping results for regional DXA body composition and bone mineral density traits in pigs

Bernau¹,

Kremer-Rücker

Međugorac³

et al. 2017

Arch. Anim. Breed.

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Abstract. In a previous study, genome-wide mapping of quantitative trait loci (QTL) for five body composition traits, three bone mineral traits and live weight was performed using whole-body dual-energy X-ray absorptiometry (DXA) data. Since QTL for bone mineral traits were rare, the current study aimed to clarify whether the mapping results were influenced by the analysed body regions. Thus, the same material (551 pigs) and methods as in the whole-body QTL mapping study were used. However, for evaluation of the DXA scans, we manually defined two body regions: (i) from the last ribs to the pelvis (A) and (ii) including the pelvis and the hind limbs (P). Since live weight was not affected by the regional analysis, it was omitted from the QTL mapping design.Our results show an overall high consistency of mapping results especially for body composition traits. Two thirds of the initial whole-body QTL are significant for both A and P. Possible causes for the still low number of bone mineral QTL and the lower consistency found for these traits are discussed. For body composition traits, the data presented here show high genome-wide Pearson correlations between mapping results that are based on DXA scans with the time-saving "whole-body standard setting" and mapping results for DXA data that were obtained by time-consuming manual definition of the regions of interest. However, our results also suggest that whole-body or regional DXA scans might generally be less suitable for mapping of bone mineral traits in pigs. An analysis of single reference bones could be more useful.

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“…Conversely, local breeds such Piau, exhibits decreased growth rate and greater fat content (Serão et al, 2011) compared to commercial pig breeds.…”

Section: Introductionmentioning

confidence: 99%

Research Article Expression of lipid metabolism and myosin heavy chain genes in pigs is affected by genotype and dietary lysine

Veloso¹,

Lopes²,

Duarte³

et al. 2018

Genet. Mol. Res.

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Candidate gene expression and intramuscular fat content in pigs

Cited by 65 publications

References 21 publications

Molecular characterization and tissue expression profile analysis of the porcine JAZF1 gene

Molecular characterization and tissue expression profile analysis of the porcine JAZF1 gene

Genome-wide QTL mapping results for regional DXA body composition and bone mineral density traits in pigs

Research Article Expression of lipid metabolism and myosin heavy chain genes in pigs is affected by genotype and dietary lysine

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