Candidate bioinks for 3D bioprinting soft tissue

Tarassoli, Sam P.; Jessop, Zita M.; Kyle, Stuart; Whitaker, Iain S.

doi:10.1016/b978-0-08-101103-4.00026-0

Cited by 16 publications

(13 citation statements)

References 171 publications

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“…Here, we briefly summarize the most commonly used natural and synthetic polymers, while we encourage the readers to refer to recent exhaustive reports on materials for bioprinting. 17 , 50 , 56 − 59 …”

Section: Biomaterials Biomaterials Inks and Bioinksmentioning

confidence: 99%

Bioprinting: From Tissue and Organ Development to in Vitro Models

et al. 2020

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Bioprinting techniques have been flourishing in the field of biofabrication with pronounced and exponential developments in the past years. Novel biomaterial inks used for the formation of bioinks have been developed, allowing the manufacturing of in vitro models and implants tested preclinically with a certain degree of success. Furthermore, incredible advances in cell biology, namely, in pluripotent stem cells, have also contributed to the latest milestones where more relevant tissues or organ-like constructs with a certain degree of functionality can already be obtained. These incredible strides have been possible with a multitude of multidisciplinary teams around the world, working to make bioprinted tissues and organs more relevant and functional. Yet, there is still a long way to go until these biofabricated constructs will be able to reach the clinics. In this review, we summarize the main bioprinting activities linking them to tissue and organ development and physiology. Most bioprinting approaches focus on mimicking fully matured tissues. Future bioprinting strategies might pursue earlier developmental stages of tissues and organs. The continuous convergence of the experts in the fields of material sciences, cell biology, engineering, and many other disciplines will gradually allow us to overcome the barriers identified on the demanding path toward manufacturing and adoption of tissue and organ replacements.

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Section: Biomaterials Biomaterials Inks and Bioinksmentioning

confidence: 99%

Bioprinting: From Tissue and Organ Development to in Vitro Models

et al. 2020

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“…Hydrogel-loaded encapsulated VEGF increased angiogenesis 5-7 fold as compared to hydrogel-loaded free VEGF, whilẽ 3.5 fold increase in angiogenesis was found in encapsulated VEGF-loaded scaffolds as compared to un-encapsulated VEGF loaded into PLGA scaffolds [49]. Although this study worked without 3D printing technology, Matrigel™ (only for mice) [50,51] and PLGA [52] scaffolds are used as bioinks for bioprinting applications and hence similar applications can further be explored in the field of bioprinting for fabrication of implants to release the growth factors and for tissue regeneration. Similar platforms for regenerative medicine applications and techniques for gene delivery from hydrogels are explored, in case of heparin-chitosan nanoparticles with PEG hydrogels for lentivirus delivery and for expressing VEGF to promote angiogenesis.…”

Section: Applications Of 3dp For Genetic Modulationmentioning

confidence: 91%

3D Printed Bioconstructs: Regenerative Modulation for Genetic Expression

Shende

Trivedi

2021

Stem Cell Rev and Rep

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Layer-by-layer deposition of cells, tissues and similar molecules provided by additive manufacturing techniques such as 3D bioprinting offers safe, biocompatible, effective and inert methods for the production of biological structures and biomimetic scaffolds. 3D bioprinting assisted through computer programmes and software develops mutli-modal nano-or micro-particulate systems such as biosensors, dosage forms or delivery systems and other biological scaffolds like pharmaceutical implants, prosthetics, etc. This review article focuses on the implementation of 3D bioprinting techniques in the gene expression, in gene editing or therapy and in delivery of genes. The applications of 3D printing are extensive and include gene therapy, modulation and expression in cancers, tissue engineering, osteogenesis, skin and vascular regeneration. Inclusion of nanotechnology with genomic bioprinting parameters such as gene conjugated or gene encapsulated 3D printed nanostructures may offer new avenues in the future for efficient and controlled treatment and help in overcoming the limitations faced in conventional methods. Moreover, expansion of the benefits from such techniques is advantageous in real-time delivery or in-situ production of nucleic acids into the host cells.

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“…Nevertheless, upon blending with collagen, cell adhesion and viability improved [81]. It is used as a hydrogel in molds for cell aggregation, or as a bioink, with embedded, non-adhering cells [82]. It becomes a gel around 40 • C, but remains quite viscous even when melted.…”

Section: Agarosementioning

confidence: 99%

3D Printing Applied to Tissue Engineered Vascular Grafts

Wenger

Giraud

2018

Applied Sciences

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The broad clinical use of synthetic vascular grafts for vascular diseases is limited by their thrombogenicity and low patency rate, especially for vessels with a diameter inferior to 6 mm. Alternatives such as tissue-engineered vascular grafts (TEVGs), have gained increasing interest. Among the different manufacturing approaches, 3D bioprinting presents numerous advantages and enables the fabrication of multi-scale, multi-material, and multicellular tissues with heterogeneous and functional intrinsic structures. Extrusion-, inkjet- and light-based 3D printing techniques have been used for the fabrication of TEVG out of hydrogels, cells, and/or solid polymers. This review discusses the state-of-the-art research on the use of 3D printing for TEVG with a focus on the biomaterials and deposition methods.

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Candidate bioinks for 3D bioprinting soft tissue

Cited by 16 publications

References 171 publications

Bioprinting: From Tissue and Organ Development to in Vitro Models

Bioprinting: From Tissue and Organ Development to in Vitro Models

3D Printed Bioconstructs: Regenerative Modulation for Genetic Expression

3D Printing Applied to Tissue Engineered Vascular Grafts

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