Candida mannan: chemistry, suppression of cell-mediated immunity, and possible mechanisms of action.

Nelson, R D; Shibata, N; Podzorski, R P; Herron, M J

doi:10.1128/cmr.4.1.1-19.1991

Cited by 25 publications

(32 citation statements)

References 86 publications

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“…The composition of cell wall mannan is broadly similar in Candida and Saccharomyces spp. (19). Mannose units are linked through al-6, al-2, al-3 (1,2,4,10,15,28), and, in the case of Candida spp., ,B1-2 (12, 13, 23-26) linkages.…”

Section: Discussionmentioning

confidence: 99%

Characterization of epitopes recognized by Candida factor 1 and 9 antisera by use of Saccharomyces cerevisiae mnn mutants

1993

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The use of Saccharomyces cerevisiae mnn mutants has facilitated the study of the epitopes recognized by antisera against several antigenic factors of the genus Candida (Candida Check; Iatron Laboratories, Tokyo, Japan). We have taken advantage of the very well characterized structure of the mannans of the different mnn mutants to compare their reactivities with the factor antisera used in the identification of different species of the genus Candida. The results of this study provide evidence that one of the antigenic determinants recognized by factor 1 antisera is the 0-linked mannose chains of the cell wall mannoproteins, while that recognized by factor 9 antiserum is the al-6-linked mannose backbone of the outer chain of the N-linked oligosaccharide.

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Section: Discussionmentioning

confidence: 99%

Characterization of epitopes recognized by Candida factor 1 and 9 antisera by use of Saccharomyces cerevisiae mnn mutants

1993

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“…Mutant strains of C. albicans that do not secrete this enzyme show significant reductions in lethality for mice (277,350). It has also been suggested that the protease could promote the release of cell wall mannan by cleaving the peptide moiety of candidal cell wall mannoproteins (381). The released mannan may cause stimulation or suppression of cell-mediated (oligosaccharide fragments of mannan appear to be potent inhibitors of cell-mediated immunity) and humoral immune functions (381).…”

Section: Hydrolytic Enzymes and Proteins With Extracellular Targetsmentioning

confidence: 99%

“…It has also been suggested that the protease could promote the release of cell wall mannan by cleaving the peptide moiety of candidal cell wall mannoproteins (381). The released mannan may cause stimulation or suppression of cell-mediated (oligosaccharide fragments of mannan appear to be potent inhibitors of cell-mediated immunity) and humoral immune functions (381). The enzyme is able to degrade a number of important defensive host proteins such as immunoglobulins and complement (232,446,451).…”

Section: Hydrolytic Enzymes and Proteins With Extracellular Targetsmentioning

confidence: 99%

Cell Wall and Secreted Proteins ofCandida albicans: Identification, Function, and Expression

Chaffin

López-Ribot

Casanova

et al. 1998

Microbiol Mol Biol Rev

655

344

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SUMMARY The cell wall is essential to nearly every aspect of the biology and pathogenicity of Candida albicans. Although it was intially considered an almost inert cellular structure that protected the protoplast against osmotic offense, more recent studies have demonstrated that it is a dynamic organelle. The major components of the cell wall are glucan and chitin, which are associated with structural rigidity, and mannoproteins. The protein component, including both mannoprotein and nonmannoproteins, comprises some 40 or more moieties. Wall proteins may differ in their expression, secretion, or topological location within the wall structure. Proteins may be modified by glycosylation (primarily addition of mannose residues), phosphorylation, and ubiquitination. Among the secreted enzymes are those that are postulated to have substrates within the cell wall and those that find substrates in the extracellular environment. Cell wall proteins have been implicated in adhesion to host tissues and ligands. Fibrinogen, complement fragments, and several extracellular matrix components are among the host proteins bound by cell wall proteins. Proteins related to the hsp70 and hsp90 families of conserved stress proteins and some glycolytic enzyme proteins are also found in the cell wall, apparently as bona fide components. In addition, the expression of some proteins is associated with the morphological growth form of the fungus and may play a role in morphogenesis. Finally, surface mannoproteins are strong immunogens that trigger and modulate the host immune response during candidiasis.

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“…Previous reports describe that C. albicans can dampen immune responses. For example, C. albicans decreases proinflammatory IFNγ and IL‐17 secretion, and immunosuppressive effects of C. albicans have been described . However, there are also descriptions of increased pro‐inflammatory effect in response to C. albicans ; such as increased pro‐inflammatory IL‐17 and TNFα secretion.…”

Section: Discussionmentioning

confidence: 99%

Intestinal epithelial cells and T cells differentially recognize and respond to Candida albicans yeast and hypha

et al. 2018

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Inflammatory bowel diseases (IBD) are a multifactorial disorder. Our understanding of the role of bacteria in the pathogenesis of IBD has increased substantially; however, only scarce data exist regarding the role of commensal fungi in maintaining intestinal homeostasis and triggering IBD. Candida albicans (C. albicans) is a member of the intestinal mycobiome and proposed to contribute to IBD pathogenesis. We aimed to investigate the influence of the two morphologies of C. albicans, yeast and hypha, on epithelial cells and T cells from IBD patients versus healthy controls. We found that C. albicans was recognized by both epithelial cells lines and T cells. In the intestinal epithelial cell line, Caco-2, response to hypha was different than to yeast cells, and this was mimicked by synthetic β-glucans and Pam3CSK4. Unstimulated T cells exhibited increased activation and pro-inflammatory cytokine secretion upon exposure, while there was no effect on apoptosis or proliferation. In contrast, C. albicans-challenged CD3-stimulated T-cells exhibited decreased activation, cytokine secretion, apoptosis, and proliferation, suggesting reciprocal responsiveness to C. albicans. Glycans alone did not mimic abovementioned influences on T cells, suggesting alternative modes of recognition. In conclusion, we provide evidence for glycan dependent and independent recognition of C. albicans by epithelial cells and T cells.

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Candida mannan: chemistry, suppression of cell-mediated immunity, and possible mechanisms of action.

Cited by 25 publications

References 86 publications

Characterization of epitopes recognized by Candida factor 1 and 9 antisera by use of Saccharomyces cerevisiae mnn mutants

Characterization of epitopes recognized by Candida factor 1 and 9 antisera by use of Saccharomyces cerevisiae mnn mutants

Cell Wall and Secreted Proteins ofCandida albicans: Identification, Function, and Expression

Intestinal epithelial cells and T cells differentially recognize and respond to Candida albicans yeast and hypha

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