Candida endophthalmitis in the premature infant

Baley, Jill E.; Annable, William; Kliegman, Robert M.

doi:10.1016/s0022-3476(81)80722-6

Cited by 84 publications

(26 citation statements)

References 13 publications

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“…All these studies but the one performed by Harms et al [8], motivated by the increasing incidence of systemic candidiasis, were prospective. Nineteen studies [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] focused on infection. They were retrospective except two [34,37].…”

Section: Discussionmentioning

confidence: 99%

Prevention of <i>Candida</i> Colonization Prevents Infection in a Neonatal Unit

et al. 2003

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This study represents a 1-year surveillance period using our epidemiology-based principles published and successfully followed since 1979: weekly culture for yeasts of oral and anal swabs, treatment with oral nystatin of all colonized newborns, and good hygiene/handwashing. Colonization was demonstrated in 23 out of 791 newborns admitted from October 1998 to September 1999. Twenty-two strains of Candida were identified: 16 C. albicans, 2 C. parapsilosis, 3 C. glabrata, and 1 C. tropicalis. Symptoms were erythema of the buttocks in 6 colonized newborns. No other culture positive for Candida could be found. Previous contamination was the main source (previous stay in an intensive care unit, rarely maternal origin). Contamination in the unit was unlikely. Eradication of Candida could be observed within 1 week. These good results, controversial in the literature, were obtained following epidemiological conclusions and support our guidelines.

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Section: Discussionmentioning

confidence: 99%

Prevention of <i>Candida</i> Colonization Prevents Infection in a Neonatal Unit

et al. 2003

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“…The most immature infants appear to be at highest risk for fungal endophthalmitis (reviewed in reference 29). In an early study of VLBW infants, endophthalmitis occurred in four (50%) of eight cases of fungal sepsis, with excellent prognosis after prompt treatment with amphotericin B and 5-fluorocytosine (28). More recent studies have reported a much lower incidence of retinal endophthalmitis, probably due to more rapid diagnosis, treatment, and surveillance of systemic candidemia.…”

Section: Vol 17 2004 Infections In Very-low-birth-weight Infants 661mentioning

confidence: 99%

Clinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants

2004

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Twenty percent of very-low-birth-weight (<1500 g) preterm infants experience a serious systemic infection, and despite advances in neonatal intensive care and antimicrobials, mortality is as much as threefold higher for these infants who develop sepsis than their counterparts without sepsis during their hospitalization. Outcomes may be improved by preventative strategies, earlier and accurate diagnosis, and adjunct therapies to combat infection and protect the vulnerable preterm infant during an infection. Earlier diagnosis on the basis of factors such as abnormal heart rate characteristics may offer the ability to initiate treatment prior to the onset of clinical symptoms. Molecular and adjunctive diagnostics may also aid in diagnosing invasive infection when clinical symptoms indicate infection but no organisms are isolated in culture. Due to the high morbidity and mortality, preventative and adjunctive therapies are needed. Prophylaxis has been effective in preventing early-onset group B streptococcal sepsis and late-onset Candida sepsis. Future research in prophylaxis using active and passive immunization strategies offers prevention without the risk of resistance to antimicrobials. Identification of the differences in neonatal intensive care units with low and high infection rates and implementation of infection control measures remain paramount in each neonatal intensive care unit caring for preterm infants

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“…Nas últimas décadas, o aumento da incidência de endoftalmite fúngica endóge-na (6) sofreu influência de vários fatores, como a difusão da antibioticoterapia (7)(8) , a cateterização intravenosa (9)(10)(11)(12) , o emprego da nutrição parenteral prolongada (13) , a imunossupressão causada por doença sistêmica ou induzida por terapia imunossupressiva (4,(14)(15)(16) , o uso de drogas ilícitas (17) e a prematuridade ao nascimento (18)(19)(20)(21)(22)(23)(24) . Os fungos têm emergido como importantes patógenos nas unidades de terapia intensiva neonatal, constituindo 0,9% do total de admissões, atingindo em especial os recém-nascidos prematuros de muito baixo peso, com incidência de infecção sistêmica de 2 a 5% (25) .…”

Section: Introductionunclassified