Candida colonization of respiratory tract: to treat or not to treat, will we ever get an answer?

Pascale, Gennaro De; Antonelli, Massimo

doi:10.1007/s00134-014-3364-y

Cited by 17 publications

(13 citation statements)

References 18 publications

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“…In this study persistent inflammation and immunosuppression were associated with Candida colonization of the lung. What to do with respiratory tract colonization in critically ill patients therefore remains an important problem [53].…”

Section: Fungal Infections and Colonizationmentioning

confidence: 99%

Asynchronies during mechanical ventilation are associated with mortality

et al. 2015

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Section: Fungal Infections and Colonizationmentioning

confidence: 99%

Asynchronies during mechanical ventilation are associated with mortality

et al. 2015

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“…Respiratory specimens, specifically sputum, get contaminated as it passes through the mouth during expectoration [26]. This then indicates that Candida species detected from respiratory specimens must not always be considered as cause for lung infection [28]. However, thorough deliberation must also be taken before considering Candida species as an innocent colonizer in the respiratory tract because it has a beta-glucan on its cell wall that acts as a lung pro-inflammatory agent causing macrophage and neutrophil dysfunction.…”

Section: Resultsmentioning

confidence: 99%

“…However, thorough deliberation must also be taken before considering Candida species as an innocent colonizer in the respiratory tract because it has a beta-glucan on its cell wall that acts as a lung pro-inflammatory agent causing macrophage and neutrophil dysfunction. Additionally, airway colonization is also associated with pulmonary inflammation and consequent cellular immune dysfunction, prolonged duration of mechanical ventilation and increased mortality [26,28]. Moreover, the biofilm producing capacity and fungal-bacterial cross-talk should not also be neglected although published clinical data based on this theory to consider Candida species as the true pathogen is still lacking [26,28].…”

Section: Resultsmentioning

confidence: 99%

Antifungal Resistance of Candida Species in Bacolod City, Philippines

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et al. 2019

J Infect Dis Epidemiol

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Candida species, a group of opportunistic infection-causing microorganisms, has shown an increasing pattern of resistance against certain antifungal drugs through time. Thus, this retrospective study was conducted to describe the antifungal resistance of Candida species isolated from a tertiary hospital in Bacolod City, Philippines from July 2017 to July 2018. A total of 184 Candida species were isolated from clinical specimens with C. albicans (61%) having the highest frequency followed by C. tropicalis (15%). Most of these Candida species were isolated from older adults (78.26%) and mid adults (15.76%). Additionally, Candida species were frequently present in respiratory specimens (69.02%) and urine specimens (20.65%). Moreover, resistance among the fungal isolates was noted against fluconazole and voriconazole with least resistance to micafungin and caspofungin.

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“…may be an offensive agent in ventilated patients hospitalized in the ICU, as this procedure can facilitate clinical worsening. Thus, the role of the fungal biofilm, possibly in combination with bacteria, should not be neglected (Pascale and Antonelli, 2014[32]).…”

Section: Discussionmentioning

confidence: 99%