Antifungal Resistance of Candida Species in Bacolod City, Philippines

C, Juayang Alain; T, Lim Joseph Peter; los, Reyes Zeith Ceve B de; B, Tuante Mary Dane; P, Batiles Zia Isabel; Nichole, Guino-o Jan Frances; A, Villanueva Francis Raphael; los, Reyes Gemma B de

doi:10.23937/2474-3658/1510076

J Infect Dis Epidemiol

2019

DOI: 10.23937/2474-3658/1510076

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Antifungal Resistance of Candida Species in Bacolod City, Philippines

Juayang Alain C¹,

Lim Joseph Peter T²,

Reyes Zeith Ceve B de los³

et al.

Abstract: Candida species, a group of opportunistic infection-causing microorganisms, has shown an increasing pattern of resistance against certain antifungal drugs through time. Thus, this retrospective study was conducted to describe the antifungal resistance of Candida species isolated from a tertiary hospital in Bacolod City, Philippines from July 2017 to July 2018. A total of 184 Candida species were isolated from clinical specimens with C. albicans (61%) having the highest frequency followed by C. tropicalis (15%)… Show more

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Cited by 2 publications

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E-test determination of antifungal susceptibility ofCandidaspecies isolated from turkeys

Sokół

Tokarzewski²,

Bobrek

et al. 2020

Journal of Veterinary Research

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IntroductionCandida species are a natural component of the intestinal tract microflora, but in favourable conditions they can cause superficial, mucosal, or even systemic candidiasis. Poultry production might be a source of human drug-resistant yeast infections, including Candida spp. The limited data concerning the antifungal susceptibility of poultry Candida isolates prompted us to carry out research to determine the susceptibility of isolates from turkey intestinal tracts.Method and MaterialsThe beak cavity, crop and cloaca were swabbed of 580 turkeys from 58 flocks in western Poland. The susceptibility tests were conducted using the E-test method with amphotericin B, fluconazole, itraconazole, and voriconazole on 52 isolates of C. albicans, C. catenulata, C. glabrata, C. palmioleophila, C. rugosa, C. krusei and C. lusitaniae.ResultsAll isolates were susceptible to voriconazole. According to the MIC values obtained for amphotericin B and fluconazole, all Candida spp. isolates were classified as susceptible according to the described breakpoints except for C. krusei, which was the only isolate that was amphotericin B-, fluconazole- and itraconazole-resistant. The susceptibility to itraconazole varied: 11 of the Candida isolates were susceptible (21.1%), 29 were dose-dependently susceptible (55.8%), and 12 isolates were resistant (23.1%).ConclusionThere are few resistant strains of Candida in turkeys, and the drug resistance varies. When Candida passes from turkeys to humans, there is a wide range of antifungal treatment options.

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E-test determination of antifungal susceptibility ofCandidaspecies isolated from turkeys

Sokół

Tokarzewski²,

Bobrek

et al. 2020

Journal of Veterinary Research

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Characterization and susceptibility of non-albicans Candida isolated from various clinical specimens in Lebanese hospitals

Husni

Zerdan²,

Samaha³

et al. 2023

Front. Public Health

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BackgroundInvasive fungal infections have presented a challenge in treatment. In the past, it was known that the frontrunner in such infections is Candida albicans with little emphasis placed on non-albicans Candida species (NAC). Studies worldwide have shown a rise in fungal infections attributed to non-albicans Candida species. The aim of this study is to describe the epidemiology of NAC infections along with an overview of resistance in Lebanese hospitals.MethodsThis is a two-year observational multi-central descriptive study. Between September 2016 and May of 2018, a total of 1000 isolates were collected from 10 different hospitals distributed all over the country. For the culture, Sabouraud Dextrose Agar was used. Antifungal Susceptibility was evaluated by determining the Minimum Inhibitory Concentration (MIC) in broth (microdilution) of the different antifungal treatments.ResultsOut of the 1000 collected isolates, Candida glabrata, being the most isolated species (40.8%), followed by Candida tropicalis: 231(23.1%), Candida parapsilosis: 103(10.3%), and other NAC species at lower percentage. Most of these isolates (88.67%) were susceptible to posaconazole, 98.22% were susceptible to micafungin, and 10% were susceptible to caspofungin.ConclusionThe change of etiology of fungal infections involving a significant increase in NAC cases is alarming due to the different antifungal susceptibility patterns and the lack of local guidelines to guide the treatment. In this context, proper identification of such organisms is of utmost importance. The data presented here can help in establishing guidelines for the treatment of candida infections to decrease morbidity and mortality. Future surveillance data are needed.

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Antifungal Resistance of Candida Species in Bacolod City, Philippines

Cited by 2 publications

References 33 publications

E-test determination of antifungal susceptibility ofCandidaspecies isolated from turkeys

E-test determination of antifungal susceptibility ofCandidaspecies isolated from turkeys

Characterization and susceptibility of non-albicans Candida isolated from various clinical specimens in Lebanese hospitals

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