Candida colonization in intensive care unit patients' urine

Passos, Xisto Sena; Sales, Werther Souza; Maciel, Patrícia Jackeline; Costa, Carolina Rodrigues; Miranda, Karla Carvalho; Lemos, Janine de Aquino; Batista, Miranildes de Abreu; Silva, Maria do Rosário Rodrigues

doi:10.1590/s0074-02762005000800016

Cited by 52 publications

(41 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These data are in accordance with other Brazilian studies [42][43][44][45] . In our study the frequency of UTI/1,000 urinary catheter (UC) days was greater than in studies realized in developing countries 46 , and although these infections are responsible for almost 40% of all NI, they continue to be unrepresentative in Brazilian hospitals, considering that the majority of them (80%) are associated with the use of urinary catheters 47,48 .…”

supporting

confidence: 93%

Nosocomial infections in a pediatric intensive care unit of a developing country: NHSN surveillance

Porto

Mantese

Arantes

et al. 2012

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Introduction: This study aimed to determine the epidemiology of the three most common nosocomial infections (NI), namely, sepsis, pneumonia, and urinary tract infection (UTI), in a pediatric intensive care unit (PICU) in a developing country and to define the risk factors associated with NI. Methods: We performed a prospective study on the incidence of NI in a single PICU, between August 2009 and August 2010. Active surveillance by National Healthcare Safety Network (NHSN) was conducted in the unit and in a case control approach, children with NI (cases) were compared with a matched controls without NI. Results: We analyzed 172 patients; 22.1% had NI, 71.1% of whom acquired it in the unit. The incidence densities of sepsis, pneumonia, and UTI per 1,000 patients/day were 17.9, 11.4, and 4.3, respectively. The most common agents in sepsis were Enterococcus faecalis and Escherichia coli (18% each); Staphylococcus epidermidis was isolated in 13% of cases. In pneumonias Staphylococcus aureus was the most common cause (3.2%), and in UTI the most frequent agents were yeasts (33.3%). The presence of NI was associated with a long period of hospitalization, use of invasive devices (central venous catheter, nasogastric tube), and use of antibiotics. The last two were independent factors for NI. Conclusions: The incidence of NI acquired in this unit was high and was associated with extrinsic factors. Keywords: Nosocomial infections. Pediatric ICU. Surveillance system. RESUMO Introdução:O objetivo deste estudo foi determinar a epidemiologia das três infecções hospitalares (IH) mais comuns -sepse, pneumonia e infecção do trato urinário (ITU) -em uma unidade de terapia intensiva pediátrica (UTIP) de um país em desenvolvimento e definir os fatores de risco associados com IH. Métodos: Nós desenvolvemos um estudo prospectivo de incidência de IH em uma única UTIP, entre agosto/2009 e agosto/2010. Foi conduzida uma vigilância ativa pelo National Healthcare Safety Network (NHSN) na Unidade e as crianças com IH (casos) foram comparadas com um grupo (controles) em um estudo caso-controle. Resultados: Nós analisamos 172 pacientes, 22,1% com IH, 71,1% adquirida na Unidade. A densidade de incidência de sepse, pneumonia e ITU por 1.000 pacientes/dia foram 17,9, 11,4, e 4,3, respectivamente. Os agentes mais comuns na sepse foram Enterococcus faecalis e Escherichia coli (18% cada), e Staphylococcus epidermidis foram isolados em 13% dos casos. Nas pneumonias Staphylococcus aureus foram os agentes mais comuns (3,2%), e nas ITUs os agentes mais frequentes foram os fungos (33,3%). A presença de IH foi associada com tempo de hospitalização prolongado, uso de procedimentos invasivos (CVC, sonda nasogástrica) e uso de antibióticos. Os dois últimos foram fatores independentes para o desenvolvimento de IH. Conclusões: A incidência de IH adquirida na Unidade foi alta, associada a fatores de risco extrínsecos. Palavras-chaves: Infecções hospitalares. UTI pediátrica. Sistema de vigilância.Nosocomial infection (NI) constitutes a major health pro...

show abstract

supporting

confidence: 93%

Nosocomial infections in a pediatric intensive care unit of a developing country: NHSN surveillance

Porto

Mantese

Arantes

et al. 2012

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

show abstract

“…Furthermore, isolation of C. glabrata as the second most frequently recovered yeast in our patients with candiduria was comparable with what Alvarez et al found in a large majority of surveyed Spanish hospitals (6). Our findings were also in concordance with an Iranian study on 744 urine samples (12) and a Brazilian study conducted on urine samples from 153 ICU patients (15). In fact, reports have indicated that the capacity of C. glabrata isolates for biofilm formation may be a potential virulence factor responsible for catheter-related candidemia in ICU patients (15,23).…”

Section: Discussionsupporting

confidence: 92%

“…Our findings were also in concordance with an Iranian study on 744 urine samples (12) and a Brazilian study conducted on urine samples from 153 ICU patients (15). In fact, reports have indicated that the capacity of C. glabrata isolates for biofilm formation may be a potential virulence factor responsible for catheter-related candidemia in ICU patients (15,23).…”

Section: Discussionsupporting

confidence: 92%

“…In spite of the importance of C. parapsilosis differentiation in clinical studies carried out on UTIs, it was not investigated in the current survey. C. tropicalis, similar to some other studies (6,14,15), had the lowest frequency. Furthermore, in two candiduria cases, initial strains of C. albicans were substituted by C. tropicalis in consequent weeks, possibly due to its antifungal resistance.…”

Section: Discussionsupporting

confidence: 91%

“…Candiduria was seen in 32.26% of ICU patients in this study. Reports from several countries indicate that candiduria is an increasing imperative problem among patients admitted to ICUs and may lead to invasive candidiasis, especially in those with critical conditions (6,8,(13)(14)(15).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Nosocomial Candiduria in Critically Ill Patients Admitted to Intensive Care Units in Qazvin, Iran

Ghiasian

Aghamirian²,

Eshghi

2014

Avicenna J Clin Microbiol Infect

View full text Add to dashboard Cite

Background: A broad variety of fungi, especially Candida species, are becoming increasingly common causes of urinary tract infections in hospital settings. Objectives: The current cross-sectional descriptive study aimed to determine the causative agents, risk factors and incidence rate of candiduria in critically ill patients, hospitalized in intensive care units (ICUs) of four Iranian hospitals. Patients and Methods: A total of 155 children and adult patients, admitted to ICUs of the four university educational hospitals, who demonstrated Candida-positive urine cultures, were examined. Samples were processed via mycological procedures by direct microscopy and culture. Results: Candiduria was confirmed in 50 (32.26 %) patients and Candida albicans was the most frequently isolated species representing 60.0% of isolates, followed by 14.0% C. glabrata, 12.0% C. parapsilosis, 10.0% C. krusei, and 4.0% C. tropicalis. Most patients were female (58%) with a mean age of 46.7 years old. Generally, 39.7% and 62% of adults and children showed candiduria, respectively. The commonest predisposing factors were antibiotic therapy (98.0%), urinary catheterization (92.0%), corticotherapy (84.0%), being female (42.6 %), use of feeding tube (56%), and extended hospitalization, respectively. Conclusions: The high frequency of candiduria in ICU patients can be decreased by shortening the duration of urinary catheterization, avoiding extra antibiotics and corticosteroids, as well as controlling the predisposing factors and underlying conditions.

show abstract

Pan-azole-Resistant Candida guilliermondii from a Leukemia Patient’s Silent Funguria

et al. 2010

View full text Add to dashboard Cite

Isolation of Candida non-albicans yeasts as commensals or pathogens from hospitalised hosts is acquiring increasing importance, due to the frequent drug resistance expressed by such organisms.Particularly, the recover of antifungal resistant C. guilliermondii is of worrisome concern, even if recovered as a saprophyte, since commensal yeasts may behave as reservoirs for resistance elements;furthermore, they may enter the bloodstream after chemotherapy-related mucosal damage has developed,thus causing life-threatening and difficult-to-treat fungemias. This communication deals with the unusual isolation of a pan-azole resistant C. guilliermondii strain from a leukaemic patient with silent candiduria and emphasizes the importance of monitoring less recurring species within the nosocomial setting to better understand fungal epidemiology within the wards and face the spread of resistance determinants. Also, we highlight the controversial significance of silent candiduria, clinical relevance of which should be investigated case by case, to exclude and/or prevent candiduria as well as renal impairment.

show abstract

Candida colonization in intensive care unit patients' urine

Cited by 52 publications

References 21 publications

Nosocomial infections in a pediatric intensive care unit of a developing country: NHSN surveillance

Nosocomial infections in a pediatric intensive care unit of a developing country: NHSN surveillance

Nosocomial Candiduria in Critically Ill Patients Admitted to Intensive Care Units in Qazvin, Iran

Pan-azole-Resistant Candida guilliermondii from a Leukemia Patient’s Silent Funguria

Contact Info

Product

Resources

About