Candida auris: an Emerging Fungal Pathogen

Abstract

has emerged globally as a multidrug-resistant health care-associated fungal pathogen. Recent reports highlight ongoing challenges due to organism misidentification, high rates of antifungal drug resistance, and significant patient mortality. The predilection for transmission within and between health care facilities possibly promoted by virulence factors that facilitate skin colonization and environmental persistence is unique among species. This minireview details the global emergence of and discusses issues relevant to clinical microbiology laboratories, hospital infection control, and antimicrobial stewardship efforts.

New and emerging infectious diseases (Ebola, Middle Eastern respiratory syndrome coronavirus, carbapenem-resistant Enterobacteriaceae, Candida auris): Focus on environmental survival and germicide susceptibility

“…128,130,131 The microbiology, clinical syndromes, diagnosis, and treatment of C auris have been reviewed. 127,[132][133][134][135][136] Genetic analyses have shown that C auris is most closely related to C lusitaniae and C haemulonii, although it has a striking divergence from some other Candida species. 127 C auris is often misidentified in conventional diagnostic laboratories using biochemical typing.…”

Laboratory Analysis of an Outbreak of Candida auris in New York from 2016 to 2018-Impact and Lessons Learned

“…In the last decade, cases of C. auris have been reported from 18 countries on five continents including Asia, Africa, Europe, South America, and North America (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Fungemia caused by C. auris is associated with a high mortality rate and therapeutic failure (13). Ecological niches of C. auris remain unknown.…”

New pathogens, new tricks: emerging, drug‐resistant fungal pathogens and future prospects for antifungal therapeutics

“…C. auris is the most recent and worrisome example of a previously unidentified pathogen that is highly refractory to existing antifungal treatment. Initially identified in Japan in 2009, 107 C. auris infections simultaneously and seemingly independently emerged in hospital settings in distinct geographical locations, 24,108 and have now been identified across five continents. 24,109 In some geographical regions, C. auris is becoming quite prevalent.…”

“…Initially identified in Japan in 2009, 107 C. auris infections simultaneously and seemingly independently emerged in hospital settings in distinct geographical locations, 24,108 and have now been identified across five continents. 24,109 In some geographical regions, C. auris is becoming quite prevalent. For example, in India, a multicenter study of intensive care units found C. auris in 19 out of 27 units, accounting for ß5% of all candidemia cases.…”