Candida arthritis in an immunocompetent patient without predisposing factors

Romero, J. M. Calvo; Vega, Jose Luis Alvarez; Vallinas, Jesús; Alberdi, R. Ortega

doi:10.1007/bf01450899

Cited by 18 publications

(3 citation statements)

References 6 publications

(7 reference statements)

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“…It occurs in immune‐compromised patients and maybe in patients with no predisposing factors. It even may occur in healthy people who do not have any signs of Candida infection (Romero, Vega, Vallinas, & Alberdi, 1998). Anti‐arthritic drugs often have severe side effects and cause fungal resistance.…”

Section: Therapeutic Benefits Of Rutin and Its Nanoformulationsmentioning

confidence: 99%

Therapeutic benefits of rutin and its nanoformulations

Negahdari

Bohlouli

Sharifi

et al. 2020

Phytotherapy Research

152

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Background Rutin as a natural flavonoid compound has revealed an extensive range of therapeutic potentials. Purpose The current paper is focused on the numerous studies on rutin nanoformulations regarding its broad spectrum of therapeutic potentials. Study and methods A review was conducted in electronic databases (PubMed) to identify relevant published literature in English. No restrictions on publication date were imposed. Results The literature search provided 7,078 results for rutin. Among them, 25 papers were related to the potential biological activities of rutin nanoformulations. Polymeric nanoparticles were the most studied nanoformulations for rutin (14 titles) and lipid nanoparticles (5 titles) were in second place. The reviewed literature showed that rutin has been used as an antimicrobial, antifungal, and anti‐allergic agent. Improving the bioavailability of rutin using novel drug‐delivery methods will help the investigators to use its useful effects in the treatment of various chronic human diseases. Conclusion It can be concluded that the preparation of rutin nanomaterials for the various therapeutic objects confirmed the enhanced aqueous solubility as well as enhanced efficacy compared to conventional delivery of rutin. However, more investigations should be conducted to confirm the improved bioavailability of the rutin nanoformulations.

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Section: Therapeutic Benefits Of Rutin and Its Nanoformulationsmentioning

confidence: 99%

Therapeutic benefits of rutin and its nanoformulations

Negahdari

Bohlouli

Sharifi

et al. 2020

Phytotherapy Research

152

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“…In einem Fallbericht von Calvo et al [156] wird über eine candidaassoziierte septische Arthritis bei einem immunkompetenten Patienten ohne prädispo-nierende Risikofaktoren berichtet. Die Durchführung einer vorangehenden Gelenkpunktion wurde bei diesem Patienten nicht beschrieben, so dass pathogenetisch eine hämatogene Streuung bei passagerer Fungämie angenommen werden muss [157].…”

Section: Invasive Candidainfektionenunclassified

Pathogenetische Bedeutung der intestinalen Candidabesiedelung

2004

Bundesgesundheitsbl - Gesundheitsforsch - Gesundheitsschutz

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“…In fact, among the various Candida species, C. albicans is the most commonly associated with fungal arthritis. In addition, the fungus causes arthritis in people without other predisposing factors (Calvo Romero et al, 1998) and even in healthy people whose initial operative cultures had no signs of Candida infection (Arnold et al, 1981). For the treatment of fungal arthritis, anti-arthritic agents that enable the removal of macrophages are applied to patients, which is very similar to treating rheumatoid arthritis.…”

Section: Introductionmentioning

confidence: 99%

Involvement of T-cell immunoregulation by ochnaflavone in therapeutic effect on fungal arthritis due to Candida albicans

Lee

2011

Arch. Pharm. Res.

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Arthritis due to pathogenic fungi is a serious disease causing rapid destruction of the joint. In the pathogenesis of arthritis, T lymphocytes are considered to be one of the major immune cells. In present study, we examined the T cell immunoregulatory effect by ochnaflavone (Och), a biflavonoid, on arthritis caused by Candida albicans that is the most commonly associated with fungal arthritis. To examine the effects of ochnaflavonon Candida albicans-caused septic arthritis, an emulsified mixture of C. albicans cell wall and complete Freund's adjuvant (CACW/CFA) was injected into BALB/c mice via hind footpad route on days -3, -2, and -1. On Day 0, Och at 1 or 2 mg/dose/time was intratraperitoneally given to mice with the swollen footpad every other day for 3 times. The footpad-edema was measured for 20 days. Results revealed that Och reduced the edema at all dose levels and furthermore, there was app. 45% reduction of the edema in animals given 2 mg-dose at the peak of septic arthritis (p < 0.05). This anti-arthritic effect was accompanied by the diminishing of the DTH (delayed type hypersensitivity) activity against the CACW and by the provoking of the dominant T helper 2 (Th2) type cytokines production (IL-4 and Il-10), which appeared to result in a suppression of T helper 1 cytokines (IFN-γ and IL-2). Besides the T cell immunoregulatory activity, Och inhibited T cells activation as evidenced by the IL-2 reduction from PMA/ionomycin-stimulated Jurkat cell line and in addition, the compound killed macrophages in a dose-dependent manner (p < 0.05). However, Och caused no hemolysis (p < 0.05). These data implicate that Och, which has anti-arthritic activity based on the Th2 dominance as well as macrophage removal, can be safely administered into the blood circulation for treatment of the arthritis caused by C. albicans. Thus, it can be concluded that Och would be an ideal immunologically evaluated agent for treating of Candida arthritis.

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Candida arthritis in an immunocompetent patient without predisposing factors

Cited by 18 publications

References 6 publications

Therapeutic benefits of rutin and its nanoformulations

Therapeutic benefits of rutin and its nanoformulations

Pathogenetische Bedeutung der intestinalen Candidabesiedelung

Involvement of T-cell immunoregulation by ochnaflavone in therapeutic effect on fungal arthritis due to Candida albicans

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