Candida and dental caries in children, adolescents and adults: A systematic review and meta-analysis

Eidt, Gustavo; Waltermann, Elen Darlise Marques; Hilgert, Juliana Balbinot; Arthur, Rodrigo Alex

doi:10.1016/j.archoralbio.2020.104876

Cited by 20 publications

(14 citation statements)

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“…6-8). On the other hand, previous studies have found that Candida albicans is signi cantly associated with dental caries (35,36) and periodontal disease (37) through induction of oral microbial dysbiosis (38) and in ammatory responses (39). Immunode ciency is also a predisposing factor for oral microbial dysbiosis (40,41) and periodontal diseases (42).…”

Section: Discussionmentioning

confidence: 98%

Current Global Status and the Epidemiology of Entamoeba gingivalis in Humans: A Systematic Review and Meta-analysis

et al. 2021

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Purpose Entamoeba gingivalis (E. gingivalis) is one of the members of the wide range of oral resident pathogens in humans, particularly found in dental plaques, surfaces of gingiva or teeth, interdental spaces and carious lesions. The purpose of the current review and meta-analysis was to determine the global prevalence of E. gingivalis infection and its association with oral diseases based on published literatures.Methods Multiple English databases (PubMed, Scopus, Science Direct, Web of Science and Google Scholar) were explored for papers published until August 2020. A total of 52 studies (including 7596 participants) met the inclusion criteria.Results The overall prevalence of E. gingivalis was estimated to be 37% (95% CI: 29% -46%). With regard to different countries, the highest and lowest pooled prevalence of E. gingivalis infection were related to Jordan with 87% (95% CI: 81% -92%) and Portugal with 3% (95% CI: 0% -10%), respectively. Based on WHO regions, the highest prevalence was related to the region of the Americas with 56% (95% CI: 31%-79%). The infection was most prevalent in 46-55 mean age groups [61% (95% CI: 21% -94%)].Among different diagnostic methods, the highest rate of the pooled prevalence was related to the molecular [53% (95% CI: 24% -81%)] and the direct methods [36% (95% CI: 25% -47%)], respectively. Our analyses revealed that E. gingivalis infection was associated with 4.34-fold increased risk of oral diseases (P < 0.05). ConclusionOur ndings revealed a high prevalence rate of the infection among periodontal disease patients with 37% (95% CI: 20% -57%). To conclude, it must be considered that E. gingivalis can be a risk factor associated with oral diseases and a wide range of research is needed to specify its role in the pathogenesis of these disorders.

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Section: Discussionmentioning

confidence: 98%

Current Global Status and the Epidemiology of Entamoeba gingivalis in Humans: A Systematic Review and Meta-analysis

et al. 2021

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“…Currently, C. albicans is regarded as a caries-related fungus and is the most widely studied fungal species ( 12 , 17 , 40 ). Epidemiological investigations have shown that children with C. albicans had a higher risk of suffering caries than children who did not ( 17 , 41 ). C. albicans is an acidogenic and acid-resistant species with independent cariogenic ability.…”

Section: Discussionmentioning

confidence: 99%

Oral Mycobiome Differences in Various Spatial Niches With and Without Severe Early Childhood Caries

Cui¹,

Wang²,

Zhang³

et al. 2021

Front. Pediatr.

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Purpose: Severe early childhood caries (S-ECC) is a microbe-mediated disease with tooth hard tissue destruction. However, the role of the fungal community in various ecological niches of deciduous dental caries has not been fully elucidated. This study aimed to analyze the differences of mycobiome in diverse spatial niches with and without S-ECC.Method: A total of 48 samples were obtained from 8 S-ECC children (SE group) and 8 caries-free children (CF group) aged 4–5 years. Unstimulated saliva (S), healthy supragingival plaque (FMIX), mixed plaque from decayed teeth (SMIX) and carious lesion (DMIX) samples were collected. The ITS2 region of the fungi was amplified and sequenced using the Ion S5™XL platform.Results: A total of 281 species were identified. Candida albicans showed relatively higher abundance in S-ECC children, while Alternaria alternata and Bipolaris sorokiniana were more enriched in CF group. In this study, the relative abundance of C. albicans in CF.FMIX (0.4%), SE.FMIX (12.5%), SE.SMIX (24.0%), and SE.DMIX (37.2%) increased successively. Significant differences of fungal species richness and diversity were observed between SE.FMIX-SE.SMIX, SE.FMIX-SE.DMIX (P < 0.05).Conclusions: The diversity of fungal communities in S-ECC children showed significant differences in various spatial niches of primary teeth. The richness of C. albicans was closely related to the caries states and depth, suggesting that it may play a crucial role in caries pathogenicity.

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“…[ 21 ] Evidence suggests that high salivary microbial counts are found in elderly populations which may facilitate the manifestation of dental caries. [ 22 ] To the best of our knowledge, there was no data on the pooled prevalence of dental caries among Indian population from different age groups, geographical region, dentition, and diagnostic criteria. Hence, the study aimed to evaluate the prevalence of dental caries across the aforementioned characteristics in the Indian population.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Dental Caries in the Indian Population

Pandey

Nandkeoliar

Tikku

et al. 2021

Journal of International Society of Preventive and Community Dentistry

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Candida and dental caries in children, adolescents and adults: A systematic review and meta-analysis

Cited by 20 publications

References 57 publications

Current Global Status and the Epidemiology of Entamoeba gingivalis in Humans: A Systematic Review and Meta-analysis

Current Global Status and the Epidemiology of Entamoeba gingivalis in Humans: A Systematic Review and Meta-analysis

Oral Mycobiome Differences in Various Spatial Niches With and Without Severe Early Childhood Caries

Prevalence of Dental Caries in the Indian Population

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