Candida albicans in celiac disease: A wolf in sheep’s clothing

Lerner, Aaron; Tenbusch, Matthias

doi:10.1016/j.autrev.2020.102621

Cited by 14 publications

(14 citation statements)

References 112 publications

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“…In order to assess its validity, we conducted a study in patients with CeD, patients with invasive candidiasis (IC), and healthy subjects, comparing the serological responses against Hwp1, gliadins, tissue transglutaminase, as well as to gliadin and Hwp1 peptides deamidated or not. Our results [ 19 ] were consistent with the initial hypothesis that even a subclinical infection caused by this ubiquitous opportunistic commensal organism, could trigger CeD following its yeast-to-hyphal transition [ 22 , 23 ].…”

Section: Introductionsupporting

confidence: 90%

Coincidence of antibodies against Hwp1 and ASCA, two distinct molecular targets of Candida albicans , reinforces the link between this fungal species and coeliac disease

Sendid,

Cao,

Colombel

et al. 2024

Virulence

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Candida albicans is an immunogen for anti- Saccharomyces cerevisiae antibodies (ASCA), a serological marker of Crohn’s disease. ASCA has also been reported in other autoimmune diseases, including coeliac disease (CeD). A strong antibody response against Hwp1, a protein associated with invasive hyphal form of C. albicans which presents peptide sequence homologies with gliadin, has also been described in CeD. This observation supports the hypothesis that C. albicans hyphal transition in C. albicans may trigger CeD onset through a mechanism of molecular/antigenic mimicry. In this study, we assessed whether the anti- C. albicans oligomannose and anti-Hwp1 protein responses may be linked despite their different pathophysiological significance. The measurement of ASCA levels in a cohort of patients involved in our previous Hwp1 study showed a significant correlation between the two biomarkers. This new observation further reinforces the link between C. albicans and CeD.

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Section: Introductionsupporting

confidence: 90%

Coincidence of antibodies against Hwp1 and ASCA, two distinct molecular targets of Candida albicans , reinforces the link between this fungal species and coeliac disease

Sendid,

Cao,

Colombel

et al. 2024

Virulence

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show abstract

“…Therefore, C. albicans may be one of the underlying reasons for CeD [119]. Later, by using antigen-antibody reaction and microchip analysis, both CeD group and C. albicans infection (CI) group expressed high anti-HWP1, anti-gliadin antibody and anti-transglutaminase (anti-TG) IgA antibody, but CeD had a higher reaction to HMP1 [142]. However, more evidence is needed to establish the involvement of C. albicans in CeD.…”

Section: Gut Mycobiota and Intestinal Diseasesmentioning

confidence: 99%

Intestinal mycobiota in health and diseases: from a disrupted equilibrium to clinical opportunities

Xia

et al. 2021

Microbiome

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Bacteria, viruses, protozoa, and fungi establish a complex ecosystem in the gut. Like other microbiota, gut mycobiota plays an indispensable role in modulating intestinal physiology. Notably, the most striking characteristics of intestinal fungi are their extraintestinal functions. Here, we provide a comprehensive review of the importance of gut fungi in the regulation of intestinal, pulmonary, hepatic, renal, pancreatic, and brain functions, and we present possible opportunities for the application of gut mycobiota to alleviate/treat human diseases.

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“…Similar, high anti- Saccharomyces boulardi antibodies were reported in CeD patients with a complete reduction or an important reduction during a gluten free diet (GFD) [ 119 ]. Candida albicans hyphal wall protein 1, containing identical or highly similar amino acid sequences related to alpha-gliadin and gamma-gliadin T-cell epitopes, might suggest that candida could play a role in CeD initiation and evolvement [ 119 , 123 ]. As for the virome component, current literature suggests that in susceptible individuals, RNA and DNA eukaryotic viruses’ infection may generate a transient disease with secondary loss of tolerance to gluten and CeD development [ 120 ].…”

Section: Microbiota and The Digestive Pathologymentioning

confidence: 99%

The Gut Microbiome and Its Implication in the Mucosal Digestive Disorders

et al. 2022

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The gastrointestinal (GI) tract is one of the most studied compartments of the human body as it hosts the largest microbial community including trillions of germs. The relationship between the human and its associated flora is complex, as the microbiome plays an important role in nutrition, metabolism and immune function. With a dynamic composition, influenced by many intrinsic and extrinsic factors, there is an equilibrium maintained in the composition of GI microbiota, translated as “eubiosis”. Any disruption of the microbiota leads to the development of different local and systemic diseases. This article reviews the human GI microbiome’s composition and function in healthy individuals as well as its involvement in the pathogenesis of different digestive disorders. It also highlights the possibility to consider flora manipulation a therapeutic option when treating GI diseases.

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Candida albicans in celiac disease: A wolf in sheep’s clothing

Cited by 14 publications

References 112 publications

Coincidence of antibodies against Hwp1 and ASCA, two distinct molecular targets of Candida albicans , reinforces the link between this fungal species and coeliac disease

Coincidence of antibodies against Hwp1 and ASCA, two distinct molecular targets of Candida albicans , reinforces the link between this fungal species and coeliac disease

Intestinal mycobiota in health and diseases: from a disrupted equilibrium to clinical opportunities

The Gut Microbiome and Its Implication in the Mucosal Digestive Disorders

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