Candida albicans and Candida dubliniensis in Periodontitis in Adolescents and Young Adults

Abstract

Aim. This study aims to evaluate the association of Candida albicans and Candida dubliniensis with periodontitis in adolescents and young adults in a Moroccan population. Methods. 426 subjects aged between 12 and 25 years were recruited for the study. A pool of plaque sample was taken. Samples were cultured on Sabouraud Chloramphenicol medium at 37°C for 24–48 hours and then identified by the Vitek 2 YST system. Clinical data and presence of Candida albicans and Candida dubliniensis were analyzed using Jamovi (Version 1.8). Results. Candida albicans was observed in 25 subjects among 68 diseased patients (37%) and in 60 subjects among 358 healthy patients (17%). It can be reported that under normal yeast conditions, there is a statistically significant difference between these two groups ( P < 0.001 ). Candida dubliniensis was more prevalent in periodontitis than in healthy subjects ( P = 0.026 ). Regarding clinical variables, subgroups of periodontitis subjects showed significant statistical differences for periodontal probing depth, clinical attachment loss, and number of decayed teeth in advanced periodontitis in comparison with initial or mild periodontitis. The results also indicate that the presence of the two species of Candida is not related to gender or age ( P > 0.05 ) nor related to the severity of the periodontal disease in this population. Conclusion. Within the limits of our study, Candida albicans is more frequently associated with periodontitis. The potential role of C. albicans in periodontitis pathogenesis is very complex. More studies on biofilm associated with different forms of periodontitis are necessary. It is also important to assess the coexistence of periodontitis and caries and the associated biofilms.

Exploring the antifungal, antibiofilm and antienzymatic potential of Rottlerin in an in vitro and in vivo approach

“…C. dubliniensis is related to oral candidiasis, especially in immunocompromised individuals, such as HIV-infected individuals 37 . Furthermore, this yeast has already been isolated from periodontal pockets of adolescents 38 . In the biofilm, many metabolites are produced, which may be associated with worsening cases of periodontitis caries 39 .…”

Cytocompatibility, Antimicrobial and Antioxidant Activity of a Mucoadhesive Biopolymeric Hydrogel Embedding Selenium Nanoparticles Phytosynthesized by Sea Buckthorn Leaf Extract

“…The most common oral infections have been reported to be caused by C. albicans , a pathogenic fungus [ 76 ]. Moreover, numerous studies have indicated the presence of C. albicans in subjects with periodontitis [ 77 ].…”

Candida dubliniensis fungemia in a patient with severe COVID-19: A case report

“…C. dubliniensis is an infrequent and cryptic pathogen; thus, its clinical features remain to be elucidated. Most C. dubliniensis isolates have been isolated from the respiratory tract [ 10 ], especially oral samples [ 17 , 18 ]; however, recent reports have suggested that rare fungi can cause invasive infections as well [ 11 , 12 ]. Although rare, one case of C. dubliniensis fungemia during the treatment of COVID-19 has been described in the literature [ 19 ].…”