Candida dubliniensis fungemia in a patient with severe COVID-19: A case report

Kakehi, Ayaka; Hagiya, Hideharu; Iio, Koji; Nakano, Yasuhiro; Ihoriya, Hiromi; Taira, Yuki; Nakamoto, Kenta; Hasegawa, Kou; Higashikage, Akihito; Otsuka, Fumio

doi:10.1016/j.jiac.2022.07.007

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Although Candida species were among the causative fungal pathogens, there are few reports of the involvement of C. dubliniensis . In Japan, there is only one reported case of fungemia acting as a rare endogenous infection in a severely ill patient with COVID-19 [ 14 ]; however, the pathogenicity of C. dubliniensis is unknown.…”

Section: Introductionmentioning

confidence: 99%

Candida dubliniensis in Japanese Oral Microbiota: A Cross-Sectional Study of Six Geographic Regions in Japan

Ohshima,

Mukai,

Watanabe

et al. 2024

Microorganisms

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Introduction: Candida dubliniensis was reclassified from the C. albicans genotype D, and reports show its frequent detection in HIV-positive individuals and easy acquisition of antifungal drug resistance. However, the oral carriage rate in healthy people and contribution to candidiasis in Japan is unclear. Methods: We conducted a cross-sectional survey of the C. dubliniensis carriage rate, performed genotyping and tested antifungal drug susceptibility and protease productivity. Specimens from 2432 Japanese subjects in six regions (1902 healthy individuals, 423 with candidiasis individuals, 107 HIV-positive individuals) were cultured using CHROMagarTMCandida, and the species was confirmed via 25S rDNA amplification and ITS sequences analyzed for genotyping. Results: The C. dubliniensis carriage rate in healthy Japanese was low in the central mainland (0–15%) but high in the most northerly and southerly areas (30–40%). The distribution of these frequencies did not differ depending on age or disease (HIV-infection, candidiasis). Genotype I, previously identified in other countries, was most frequent in Japan, but novel genotypes were also observed. Six antifungal drugs showed higher susceptibility against C. albicans, but protease productivity was low. Conclusions: Oral C. dubliniensis has low pathogenicity with distribution properties attributed to geography and not dependent on age or disease status.

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Section: Introductionmentioning

confidence: 99%

Candida dubliniensis in Japanese Oral Microbiota: A Cross-Sectional Study of Six Geographic Regions in Japan

Ohshima,

Mukai,

Watanabe

et al. 2024

Microorganisms

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“…Moreover, C. dubliniensis has been associated with oral candidiasis in diabetic patients undergoing insulin treatment [ 12 ]. Recently, C. dubliniensis has been reported in SARS-CoV-2 infected patients [ 13 ]. The increased clinical awareness of C. dubliniensis is attributed due to antifungal drug resistance and reduced susceptibility to antifungal drugs; for instance, fluconazole, flucytosine, voriconazole, and amphotericin B [ 1 , 7 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Secreted Aspartyl Proteinases Targeted Multi-Epitope Vaccine Design for Candida dubliniensis Using Immunoinformatics

Akhtar¹,

Magdaleno

Ranjan

et al. 2023

Vaccines

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Candida dubliniensis is an opportunistic pathogen associated with oral and invasive fungal infections in immune-compromised individuals. Furthermore, the emergence of C. dubliniensis antifungal drug resistance could exacerbate its treatment. Hence, in this study a multi-epitope vaccine candidate has been designed using an immunoinformatics approach by targeting C. dubliniensis secreted aspartyl proteinases (SAP) proteins. In silico tools have been utilized to predict epitopes and determine their allergic potential, antigenic potential, toxicity, and potential to elicit interleukin-2 (IL2), interleukin-4 (IL4), and IFN-γ. Using the computational tools, eight epitopes have been predicted that were then linked with adjuvants for final vaccine candidate development. Computational immune simulation has depicted that the immunogen designed emerges as a strong immunogenic candidate for a vaccine. Further, molecular docking and molecular dynamics simulation analyses revealed stable interactions between the vaccine candidate and the human toll-like receptor 5 (TLR5). Finally, immune simulations corroborated the promising candidature of the designed vaccine, thus calling for further in vivo investigation.

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Multiple drugs

2022

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Candida dubliniensis fungemia in a patient with severe COVID-19: A case report

Cited by 4 publications

References 29 publications

Candida dubliniensis in Japanese Oral Microbiota: A Cross-Sectional Study of Six Geographic Regions in Japan

Candida dubliniensis in Japanese Oral Microbiota: A Cross-Sectional Study of Six Geographic Regions in Japan

Secreted Aspartyl Proteinases Targeted Multi-Epitope Vaccine Design for Candida dubliniensis Using Immunoinformatics

Multiple drugs

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