Cancers vésiculaires de découverte fortuite

Gléhen, Olivier; Czyglik, O.; Donsbeck, A.V; Isaac, Sylvie; Gilly, François Noël; François, Y.; Vignal, J

doi:10.1016/s0001-4001(00)00114-8

Cited by 10 publications

(6 citation statements)

References 19 publications

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“…It is well known that in the almost cases, the surgeon can perfectly suspect this cancer after opening the gallbladder. It is macroscopically apparent on the mucosa of the gallbladder in almost cases [2,3,6,7,11,12]. In our series, it was the case (macroscopically visible) in 29 cases (87.8%) after the opening of the gallbladder by the surgeon.…”

Section: Discussionmentioning

confidence: 45%

“…Currently, it can be recognized in 2 situations:  On preoperative course with ultrasonography [3][4][5].  On the histological examination after cholecystectomy for biliary lithiasis [5][6][7][8]. For a clinician to make a diagnosis before a surgical step, he needs an expert radiologist who should be vigilant during ultrasound examination.…”

Section: Discussionmentioning

confidence: 99%

“…The treatment of early gallbladder cancer is surgery [6,[11][12][13][14][15]. The best treatment is cholecystectomy which is curative for the majority of the authors [8,[16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

“…If it is a pT1a cancer the cholecystectomy is sufficient. The invasive form (PT2-T3) and PT1b needs a second operation [6,8]. The quality of the histological examination is fundamental.…”

Section: Discussionmentioning

confidence: 99%

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Early Gallbladder Cancer: Clinical, Morphological, Therapeutic and Evolutionary Aspects

Salah¹,

Abid²

2013

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Introduction:The early cancer of gallbladder is an entity which is not well recognized currently. It is a cancer which does not extend beyond the muscularis layer of the gallbladder and it is characterized in almost of cases by the absence of lymph node and visceral invasion. Patients and Method: We have conducted this retrospective study of all our cases of early gallbladder cancer treated in our surgical unit. We have studied these through clinical, morphological, therapeutical and evolutionary aspects. Results: Of 202 gallbladder carcinoma, 33 cancers were classified as early cancer. 25 were females and 8 were males. The mean age was 56.4 years (41 -70 years). All patients were free of gallbladder cancer symptoms and all except one had normal CEA and CA19.9. 2 patients had synchronous tumors (one colonic cancer and one rectal cancer). For 16 patients, the diagnosis was done by ultrasonography and 17 by histological examination of the specimen removed for biliary lithiasis. 8 patients had PT1a tumor (confined only to mucosa) and 25 had PT1b tumor (tumor infiltration of the muscular layer). For 19 patients who benefited from extensive lymphadenectomy, only one (5.3%) had lymph node infiltration. 16 patients had a simple cholecystectomy and in two cases, the cholecystectomy was associated with bile duct resection. 17 patients had hepatectomy with extensive lymphadenectomy. 2 patients had a simultaneous right colectomy and abdominoperineal resection and another one benefited from choledocal cyst resection. 3 patients benefited from stone removal from bile duct and two had tumor removal from bile duct (ruptured tumor in the bile duct). 1 patient (3.7%) died in postoperative course (hospital mortality). In the follow-up period, 4 patients died from intercurrent causes. Two patients presented a recurrence at 14 and 36 months and died respectively at 19 and 42 months. One patient presented a bile duct cancer at 66 months. She died at 78 months after palliative treatment. Currently, 22 patients (66.7%) are still alive without recurrence with mean and median survival of 53 and 31 months. Conclusion: Early gallbladder cancer is an entity which must be known by the radiologist and the surgeon. Recognized on time and well treated, early gallbladder cancer can be cured and its prognosis is excellent.

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Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 99%

“…The treatment of early gallbladder cancer is surgery [6,[11][12][13][14][15]. The best treatment is cholecystectomy which is curative for the majority of the authors [8,[16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

“…If it is a pT1a cancer the cholecystectomy is sufficient. The invasive form (PT2-T3) and PT1b needs a second operation [6,8]. The quality of the histological examination is fundamental.…”

Section: Discussionmentioning

confidence: 99%

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Early Gallbladder Cancer: Clinical, Morphological, Therapeutic and Evolutionary Aspects

Salah¹,

Abid²

2013

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“…Trente-cinq patients de notre série entrent dans ce cadre. Il y a actuellement une convergence de vue chez tous les auteurs pour dire que les cancers invasifs (pT2, pT3) doivent être réopérés et bénéficier d'une extension du geste [4,11,20,21], alors que les cancers précoces purement muqueux (pT1a) sont guéris par la simple cholécystectomie. Dans notre expérience, près de 80 % des patients réopérés après une découverte histologique pour un cancer invasif avaient un résidu tumoral soit ganglionnaire, soit tissulaire (lit vésiculaire, péritoine, foie), soit les deux.…”

Section: Patients Et Méthodesunclassified

La chirurgie radicale pour cancer de la vésicule biliaire. Résultats d’une attitude thérapeutique agressive chez 130 patients

Berkane¹,

Benamara²,

Bennani³

et al. 2011

J Afr Cancer

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Contexte : Le cancer de la vésicule biliaire, relativement fréquent en Algérie, est réputé pour son pronostic sombre. La survie à cinq ans tous stades confondus est infé-rieure à 5 %. Depuis 12 ans, nous avons adopté une attitude chirurgicale résolument agressive vis-à-vis de ce cancer. Cette chirurgie radicale qui consiste en bisegmentectomie IV-V + lymphadénectomie pour les stades invasifs est élargie selon l'extension tumorale rencontrée aux organes de voisinage. Une chimiothérapie adjuvante y est associée en postopératoire. Cent trente patients ont ainsi bénéficié d'une exérèse à visée radicale. L'hépatectomie a été élargie à un ou plusieurs organes de voisinage chez 58 patients (44,5 %). L'atteinte ganglionnaire a été retrouvée chez 67 patients (51,5 %). Nous déplorons une lourde morbimortalité respectivement de 28,5 et 18,5 %. Soixante-six patients (62,3 %) parmi les survivants à l'intervention ont bénéficié d'une chimiothérapie systémique. La survie globale à cinq ans est de 16 % avec une médiane de 17 mois. Conclusion : Ces résultats nous incitent à poursuivre dans cette voie, mais des efforts sont à fournir pour diminuer la mortalité postopératoire en premier lieu en améliorant la prise en charge des patients ictériques et en sélectionnant mieux ceux avec atteinte multiviscérale. Pour citer cette revue : J. Afr. Cancer 3 (2011). Mots clés Cancer de la vésicule biliaire · Chirurgie radicale · Amélioration pronostique · Découverte histologiqueAbstract Background: In Algeria, the incidence of gallbladder cancer is higher and prognosis is poor. Five-year survival for all stages is less than 5%. For the past 12 years, we have adopted an aggressive surgical approach against this carcinoma. Procedure: This radical surgical approach includes a bisegmentectomy for stages IV-Vand extensive lymphadenectomy for invasive stages. This resection can be extended to all other organs which may be involved in the tumour (44.5%). Systemic adjuvant chemotherapy was administered postoperatively. Nodal infiltration was noted in 67 cases (51.5%). Results: Morbidity and mortality were 28.5% and 18.5%, respectively. Overall survival at 5 years was 16%, with a median of 17 months. Conclusions: These results (median and overall survival) encourage us to continue in this way, but a lot of effort must be made to reduce postoperative mortality and improve the management of patients with jaundice and those with the involvement of multiple organs. To cite this journal: J. Afr. Cancer 3 (2011).

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Variants of Gallbladder Carcinoma

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Cancers vésiculaires de découverte fortuite

Cited by 10 publications

References 19 publications

Early Gallbladder Cancer: Clinical, Morphological, Therapeutic and Evolutionary Aspects

Early Gallbladder Cancer: Clinical, Morphological, Therapeutic and Evolutionary Aspects

La chirurgie radicale pour cancer de la vésicule biliaire. Résultats d’une attitude thérapeutique agressive chez 130 patients

Variants of Gallbladder Carcinoma

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