Cancers of the Pancreas and Hepatobiliary System

Sauerland, Carmel; Engelking, Constance; Wickham, Rita; Pearlstone, David B.

doi:10.1016/j.soncn.2008.10.006

Cited by 12 publications

(3 citation statements)

References 55 publications

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“…The incidence of pancreatic cancer has been relatively stable worldwide over the last few decades [ 96 - 98 ]. It is more frequent in men than in women [ 99 , 100 ]. Pancreatic cancer cells are ER alpha and beta positive and consequently may be modulated by oestrogen [ 101 ] which is consistent with similar mechanisms observed in xenoestrogen-related cancers [ 102 , 103 ].…”

Section: Pancreatic Cancermentioning

confidence: 99%

Environmental exposure to xenoestrogens and oestrogen related cancers: reproductive system, breast, lung, kidney, pancreas, and brain

et al. 2012

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The role of steroids in carcinogenesis has become a major concern in environmental protection, biomonitoring, and clinical research. Although historically oestrogen has been related to development of reproductive system, research over the last decade has confirmed its crucial role in the development and homeostasis of other organ systems. As a number of anthropogenic agents are xenoestrogens, environmental health research has focused on oestrogen receptor level disturbances and of aromatase polymorphisms. Oestrogen and xenoestrogens mediate critical points in carcinogenesis by binding to oestrogen receptors, whose distribution is age-, gender-, and tissue-specific. This review brings data about cancer types whose eatiology may be found in environmental exposure to xenoestrogens. Cancer types that have been well documented in literature to be related with environmental exposure include the reproductive system, breast, lung, kidney, pancreas, and brain. The results of our data mining show (a) a significant correlation between exposure to xenoestrogens and increased, gender-related, cancer risk and (b) a need to re-evaluate agents so far defined as endocrine disruptors, as they are also key molecules in carcinogenesis. This revision may be used to further research of cancer aetiology and to improvement of related legislation. Investigation of cancers caused by xenoestrogens may elucidate yet unknown mechanisms also valuable for oncology and the development of new therapies.

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Section: Pancreatic Cancermentioning

confidence: 99%

Environmental exposure to xenoestrogens and oestrogen related cancers: reproductive system, breast, lung, kidney, pancreas, and brain

et al. 2012

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“…Long-term studies have shown somatostatin analogs to be safe and well tolerated while producing tumor stabilization in 30%-70% of patients for months to years at a time (Chadha et al, 2009). In contrast, adenocarcinoma of the pancreas has a bleak outcome with only 4% of patients living five years or more after diagnosis (Sauerland, Engelking, Wickham, & Pearlstone, 2009). …”

Section: Pancreatic Tumorsmentioning

confidence: 99%

Celiac Plexus Block in Pancreatic Neuroendocrine Tumors

Morturano

Dunphy²

2011

Clinical Journal of Oncology Nursing

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Pancreatic neuroendocrine tumors (pNETs), an uncommon finding, are distinct from pancreatic carcinomas. When pNETs are unresectable and progressive, visceral pain often presents and is challenging to treat. Opioids commonly used for pain control are difficult to implement in this setting because of adverse side effects such as constipation. Neurolytic celiac plexus blocks are indicated in the treatment of visceral pain related to upper abdominal malignancies when opioid analgesia does not provide adequate relief or is contraindicated because of side effects. As a result, this article presents a brief review of pNETs, celiac plexus blocks, associated side effects, and contraindications along with related literature in the context of a case study.

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“…Entretanto, apenas uma parcela dos pacientes apresenta esta forma de doença localizada no momento do diagnóstico. 12,26,29 Figura 7: Desenvolvimento do câncer de pâncreas no estádio 0 e I.…”

Section: Câncer De Pâncreasunclassified

Perfil metabólico de nucleosídeos em amostras de soro sanguíneo de indivíduos com câncer de próstata e pâncreas avaliado por cromatografia liquida acoplada a espectrometria de massas

Guedes¹

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Cancers of the Pancreas and Hepatobiliary System

Cited by 12 publications

References 55 publications

Environmental exposure to xenoestrogens and oestrogen related cancers: reproductive system, breast, lung, kidney, pancreas, and brain

Environmental exposure to xenoestrogens and oestrogen related cancers: reproductive system, breast, lung, kidney, pancreas, and brain

Celiac Plexus Block in Pancreatic Neuroendocrine Tumors

Perfil metabólico de nucleosídeos em amostras de soro sanguíneo de indivíduos com câncer de próstata e pâncreas avaliado por cromatografia liquida acoplada a espectrometria de massas

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