Cancers of the ampulla of vater: Demographics, morphology, and survival based on 5,625 cases from the SEER program

Albores‐Saavedra, Jorge; Schwartz, Arnold M.; Batich, Kristen A.; Henson, Donald E.

doi:10.1002/jso.21374

Cited by 250 publications

(194 citation statements)

References 26 publications

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“…Ampullary cancers are rare malignant neoplasms that arise from the ampulla of Vater (Albores‐Saavedra, Schwartz, Batich, & Henson, 2009). Although this disease represents only 0.5% of gastrointestinal cancers and 7% of cancers arising in the region of the head of the pancreas, the rates of ampullary cancer have been rising annually over the past few years (Ang, Shia, Tang, Katabi, & Klimstra, 2014; Siegel, Miller, & Jemal, 2017).…”

Section: Introductionmentioning

confidence: 99%

Prognostic impact of circulating tumor cells in patients with ampullary cancer

Sun

Liang

Wang

et al. 2018

Journal Cellular Physiology

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Circulating tumor cells (CTCs) are an important topic of investigation for both basic and clinical cancer research. In this prospective study, we evaluated the clinical role of CTCs in ampullary cancer. We analyzed blood samples from 62 consecutively diagnosed patients with ampullary adenocarcinoma and 24 healthy controls for their CTC content. Combined data from immunostaining of CD45, 4′,6‐diamidino‐2‐phenylindole (DAPI), and fluorescence in situ hybridization with a chromosome 8 centromere (CEP8) probe were used to identify CTCs; cells that were CD45‐/DAPI+/CEP8>2 were considered CTCs. The Cox proportional hazards model was used to assess the relationship between CTCs, clinical characteristics, and patient outcomes. We detected ≥2 CTCs/3.2 ml whole blood in 43 of 62 patients (69.4%), as well as ≥5 CTCs/3.2 ml in 16 of these patients (25.8%). A CTC cutoff value of 2 cells/3.2 ml achieved 69.4% sensitivity and 95.8% specificity as a diagnostic tool; CTCs were associated with tumor burden. CTC levels ≥3/3.2 ml (hazard ratio [HR]: 2.5, 95% confidence interval [CI]: (1.2–5.2), p = 0.014) and ≥5/3.2 ml (HR: 3.5, 95% CI: 1.7–7.3, p < 0.001) were both associated with shorter disease‐free survival. Moreover, ≥3 CTCs/3.2 ml (HR: 2.7, 95% CI: 1.2–6.3, p = 0.019) and ≥5 CTCs/3.2 ml (HR: 3.8, 95% CI: 1.8–8.5, p < 0.001) were predictive of shorter overall survival. CTC assessment may help identify patients with ampullary cancer who are at high risk of an unfavorable outcome.

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Section: Introductionmentioning

confidence: 99%

Prognostic impact of circulating tumor cells in patients with ampullary cancer

Sun

Liang

Wang

et al. 2018

Journal Cellular Physiology

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“…Histologically, most tumors are adenocarcinomas and rarely present differentiation mucinous, papillary or adenoescamosa [1,21].…”

Section: Phenotypic Evaluationmentioning

confidence: 99%

“…In contrast, pancreaticobiliary type appears to originate from the epithelium of the same name, given the frequent papillary arrangements found in this tissue type [23]. Albores-Saavedra et al reviewed these criteria and classified the ampullary tumors according to histological findings [1].…”

Section: Phenotypic Evaluationmentioning

confidence: 99%

“…Several studies have associated clinical and biological behavior of the ampullary carcinoma intestinal tumors [1,[23][24][25][26][27][28][29][30]. Among the reasons are: the highest frequency of intestinal type in most studies (Table 1), the process of carcinogenesis by chromosomal instability ("adenomacarcinoma" sequence), as is observed in colorectal cancers.…”

Section: Phenotypic Evaluationmentioning

confidence: 99%

“…The incidence of ampullary adenocarcinomas is 4 to 6 cases per one million inhabitants per year, with a higher incidence in men (0.7/100,000) than in women (0.45/100,000) [1][2][3]. It accounts for less than 1% of all gastrointestinal tract tumors [4], and about 6% to 30% of periampular neoplasms [5].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Carcinoma of Ampulla of Vater: Carcinogenesis and Immunophenotypic Evaluation

Rosa¹,

Peria²,

Brunaldi³

2017

J Clin Epigenet

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Effect of Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid or Gemcitabine vs Observation on Survival in Patients With Resected Periampullary Adenocarcinoma

Neoptolemos,

Moore,

Cox

et al. 2012

JAMA

509

300

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ERIAMPULLARY CARCINOMAS arise from the head of the pancreas in the region of the ampulla of Vater and apart from pancreatic ductal adenocarcinoma comprise carcinomas of the bile duct, the ampulla itself, and the periampullary duodenum. 1,2 The incidence rates per 10 5 are 11.7 for pancreatic, 0.88 for bile duct, 0.49 for ampullary, and 0.01 for Author Affiliations are listed at the end of this article.

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Cancers of the ampulla of vater: Demographics, morphology, and survival based on 5,625 cases from the SEER program

Abstract: Prognostic factors include histologic type, grade, stage, and coexisting adenomas. These data should be included in pathology reports. Although certain histologic types exhibit morphologic differences, their pathogenesis appears to be similar.

Cited by 250 publications

References 26 publications

Prognostic impact of circulating tumor cells in patients with ampullary cancer

Prognostic impact of circulating tumor cells in patients with ampullary cancer

Carcinoma of Ampulla of Vater: Carcinogenesis and Immunophenotypic Evaluation

Effect of Adjuvant Chemotherapy With Fluorouracil Plus Folinic Acid or Gemcitabine vs Observation on Survival in Patients With Resected Periampullary Adenocarcinoma

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