Cancerous diseases in aquatic animals and their association with environmental pollutants: A critical literature review

Mix, Michael C.

doi:10.1016/0141-1136(86)90013-9

Cited by 180 publications

(93 citation statements)

References 204 publications

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“…The combined methodology coupled with the use of supportive laboratory bioassays should help to define causal links between some classes of contaminant and specific types of toxic injury in fish. In Europe, only a few field studies have traced links between fish disease and chemical exposure (see Kohler 1989) but in North America where xenobiotic contamination of the marine environment has been investigated more extensively, good data exists for linking hepatic neoplasms (and related lesions) with exposure to toxic chemicals in marine fish species (Mix 1986, Malins et al 1988. Murchelano & Wolke 1991, Varanasi & Stein 1991.…”

Section: Introductionmentioning

confidence: 99%

Toxicological pathology of dab Limanda limanda along pollution gradients in the southern North Sea

Simpson¹,

Hutchinson²

1992

Mar. Ecol. Prog. Ser.

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During the Bremerhaven Workshop non-overtly diseased female dab Limanda lirnanda, 17 to 27 cm in length, were sampled for detailed histopathology along a 200 km transect (Stns 3, 5, 6, 7, 8 & 9) extending out from the Elbe estuary region (Stn 3) to the northwestern region of the Dogger Bank (Stn 9) in the southern North Sea. During the period March 12 to 30, 1990, approximately 20 fish were examined from each of the above stations Histopathological changes seen that were considered to be consistent with adverse exposure to xenobiotic compounds were confined to the heart, liver and kidney. In the heart, the prevalence of myocardial vacuolation, suggestive of fatty change, was significantly higher (p < 0.05) in fish from Stn 3 compared to fish from all other stations. In the llver, the most important lesions seen were well-developed foci of cellular alteration, high mitotlc activity and high neutral lipid accumulation in livers of dab sampled from the most inshore station (Stn 3) compared to the reference station (Stn 7). Foci of cellular alteration and high neutral lipid accumulation were significantly greater ( p < 0.05) at Stn 3 compared to Stn 7. In the kidney, the prevalance of proteinaceous/cellular debris in Bowman's space of renal glomeruli was significantly greater ( p < 0.01) in fish from Stn 3 compared to fish from Stn 7 The high prevalence of foci of cellular alteration and high neutral lipid accumulation In hepatocytes in the liver of dab are consistent with the effects of adverse exposure to toxic xenobiotics. The other non-infectious changes seen in the liver, as well as those seen In the heart and kidney, are also consistent with xenobiotic exposure but other possible explanations are considered. The value of using detailed histopathology on small numbers of dab which appear grossly normal is clearly demonstrated.

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Section: Introductionmentioning

confidence: 99%

Toxicological pathology of dab Limanda limanda along pollution gradients in the southern North Sea

Simpson¹,

Hutchinson²

1992

Mar. Ecol. Prog. Ser.

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“…The best-studied example ofcarcinogen induction of fish tumors is the case of liver tumors in bottomdwelling marine flatfish in Washington State. Tumors appear to be related to sediment levels ofPAHs (1,(15)(16)(17). In the fresh water environment, brown bullheads from a variety of PAHcontaminated areas such as the Black, Buffalo, and Fox rivers have been reported to have an elevated incidence ofliver tumors (1).…”

Section: Effects Of Pahs On Aquatic Organismsmentioning

confidence: 99%

“…Tumors appear to be related to sediment levels ofPAHs (1,(15)(16)(17). In the fresh water environment, brown bullheads from a variety of PAHcontaminated areas such as the Black, Buffalo, and Fox rivers have been reported to have an elevated incidence ofliver tumors (1). Bile from such bullheads exhibits fluorescent metabolites resulting from the metabolism ofPAHs (18).…”

Section: Effects Of Pahs On Aquatic Organismsmentioning

confidence: 99%

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Carcinogen Adducts As an Indicator for the Public Health Risks of Consuming Carcinogen-Exposed Fish and Shellfish

Dunn¹

1991

Environmental Health Perspectives

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In anorganim with actrve nmtaboc systems for a given carcinogen, adducts are generally much longer lived than the carcinogens that formed them. Thus, the detection ofDNA-or protdn-carcinogen adductsin aquatic foodstuffs can act as anindicatorofprior carnog exposur The presnee ofDNA adducts would, in addition, suggest a mutagenic/carcinogenic risk to the aquatic orn itself. Wrtebrate fish are chacterized by high levels ofcarcinogen metabolism, low body burdens ofcarcinogen, the formation ofcarcinogen-macromolecule adducs, and theoccurrence ofpollutionrelated tumor Shellfish, on the other hand, h elowlevesofcarclnogenmetabos, high body burdens ofarcinogen, and have little or no evidence ofcarcinogen-macromolecule adductsor tums Th consumpton ofcarcinogen adducts in aquatic foodt Is unlkely to reprent a human helth hazard. There are no metaboik pathways by which proteincarcinogen or DNA-carcinogen adducts could reform carcnogen Incorporation via salage pathways of prformed mucleoside-carcinogen adducts from fo ts into newly syntbeized human DNA is theo lly ponsihIe However, absolute levelsofnucleoside-carcinogen leves in aquatic foodstuffs from polluted areas arevery low, and the incorporation of peormed adducts into DNA is songly discrminated against by the fidelity of DNA synthesis.

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“…Much ofthe literature can be found in the following proceedings, reviews and selected research papers (26,(29)(30)(31)(32)(33)(34)(35)(36)(37). Reviewers also note that molluscan neoplasms are predominandy ofhemic origin and that the evidence favors a viral rather than a chemical etiology.…”

Section: Discussionmentioning

confidence: 99%

Carcinogenicity of Black Rock Harbor Sediment to the Eastern Oyster and Trophic Transfer of Black Rock Harbor Carcinogens from the Blue Mussel to the Winter Flounder

Gardner

Yevich

Harshbarger

et al. 1991

Environmental Health Perspectives

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The eastern oyster (Crassostrea ripinica) developed neoplastic disorders when experimentally exposed both in the laboratory and field to chemically contaminated sediment from Black Rock Harbor (BRH), Bridgeport, Connecticut. oysters also occurs in blue mussels (Mytilusekdis). Winter flounder fed BRH-contaminated blue mussels contained xenobiotic chemicals analyzed in mussels. The flounder developed renal and pancreatic neoplasms and hepatotokc neoplastic precurs lesions, demons 4t trophic transfer of sedimentbound carcinogens up the food chain.

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Cancerous diseases in aquatic animals and their association with environmental pollutants: A critical literature review

Cited by 180 publications

References 204 publications

Toxicological pathology of dab Limanda limanda along pollution gradients in the southern North Sea

Toxicological pathology of dab Limanda limanda along pollution gradients in the southern North Sea

Carcinogen Adducts As an Indicator for the Public Health Risks of Consuming Carcinogen-Exposed Fish and Shellfish

Carcinogenicity of Black Rock Harbor Sediment to the Eastern Oyster and Trophic Transfer of Black Rock Harbor Carcinogens from the Blue Mussel to the Winter Flounder

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