Cancer Trends in China

Zhao, Ping; Dai, Min; Chen, Wanqing; Li, Ni

doi:10.1093/jjco/hyp187

Cited by 277 publications

(199 citation statements)

References 8 publications

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“…Colorectal cancer is one of the most common malignant tumors which contribute to the fifth cause of tumor death rates in China 1, 2. The incidence of colorectal cancer is nearly 5% and the 5‐year survival rate ranges from 40% to 60% 3.…”

Section: Introductionmentioning

confidence: 99%

A miRNAs panel promotes the proliferation and invasion of colorectal cancer cells by targeting GABBR1

et al. 2016

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MicroRNAs (miRNAs) have been implicated in the regulation of colorectal cancer. Despite the expression of miR‐17‐92 cluster in cancer has been gradually revealed, the role of each individual miRNAs in colorectal cancer still remains unclear. We studied the impact of miR‐106a/b, miR‐20a/b, and miR‐17 of miR‐17‐92 cluster on colorectal cancer cells. Real‐time quantitative polymerase chain reactions (RT‐PCR) were used to test these five miRNAs expression in colorectal cancer cell line HCT116. 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2‐H‐tetrazolium bromide (MTT) assays, Bromodeoxyuridine (BrdU), and Transwell invasion assays were used to explore the effects of these five miRNAs in colorectal cancer cells. Luciferase reporter assay, RT‐PCR, and western blotting were performed to validate the interaction of these five miRNAs with the gamma‐amino‐butyric acid type B receptor 1(GABBR1). We found that these five miRNAs were significantly upregulated in colorectal cancer samples compared with normal tissues. Forced expression of these five miRNAs significantly promoted HCT116 and HT‐29 cells proliferation and invasion. We further found that these five miRNAs function as oncogenes in colorectal cancer by specifically binding to the 3‐untranslated regions (3′UTR) of GABBR1.Furthermore, inhibition of GABBR1 could mimic the function of miRNAs in HCT116 cells, while overexpression of GABBR1 blocked the function of miRNAs‐promoted proliferation and invasion. In conclusion, miR‐106a/b, miR‐20a/b, and miR‐17 contribute to the proliferation and invasion of colorectal cancer by targeting their common target gene, GABBR1, and played a critical role in the proliferation and invasion of colorectal cancer.

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Section: Introductionmentioning

confidence: 99%

A miRNAs panel promotes the proliferation and invasion of colorectal cancer cells by targeting GABBR1

et al. 2016

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“…It is estimated 21,600 newly diagnosed cases of gastric cancer and 10,990 deaths would occur in the USA in 2013, although gastric cancer (3.1%) enjoyed the second largest annual declines in death rates over the past 10 years of data (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009) (Siegel et al, 2013;Society, 2013). It is reported nearly two-thirds of gastric cancer cases and deaths occur in developing countries, such as China, Korea, Central and South America and Middle East (Crew et al, 2006;Zhao et al, 2010;Jemal et al, 2011). Take China as an example, the crude gastric cancer mortality rate was 22.97 per 100,000 in urban areas and 25.58 per 100,000 in rural areas in 2004(Yang et al, 2006Jemal et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Association Between MDM2 SNP309 T>G and Risk of Gastric Cancer: A Meta-analysis

Tian

Tian²,

Ma³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: As a negative regulator of P53, MDM2 plays an important role in carcinogenesis; a polymorphism in its promoter region. SNP309 T>G, is known to increase the expression of MDM2, thus being considered related to higher susceptibility to neoplasia. However, no agreement has been achieved regarding its effects on gastric cancer. Methods: The present systematic meta-analysis was performed based on comprehensive literature search from Pubmed, Web of science and CBM databases. Results: It was suggested from 6 independent studies that the GG genotype is associated with a significantly increased risk of gastric cancer (Recessive: OR = 1.43, 95% CI = 1.08-1.91, P = 0.013), and subgroup analysis also confirmed the relationship (English publications-recessive model: OR = 1.45, 95% CI = 1.10-1.91, P = 0.009; Studies in China-recessive model: OR = 1.58, 95% CI = 1.08-2.30, P = 0.017). No publication bias was detected. Conclusion: The meta-analysis indicated a significant inverse association between GG genotype carriage and elevated risk of gastric cancer. However, more studies and detailed information are needed to fully address the topic.

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“…In China, gastric carcinoma is the second most common cancer (Zhao et al, 2010). It is reported that almost two thirds of the cases of this type of cancer occur in developing countries and 42% in China alone.…”

Section: Introductionmentioning

confidence: 99%

Role of Integrin-Linked Kinase in Multi-drug Resistance of Human Gastric Carcinoma SGC7901/DDP Cells

Song

Jiang²,

Zhao³

2012

Asian Pacific Journal of Cancer Prevention

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Gastric carcinoma is a leading cause of cancer death in the world and multi-drug resistance (MDR) is an essential aspect of gastric carcinoma chemotherapy failure. Recent studies have shown that integrin-linked kinase (ILK) is involved in metastasis of human tumors, expression silencing of ILK inhibiting the metastasis of several types of cultured human cancer cells. However, the role and potential mechanism of ILK to reverse the multidrug resistance in human gastric carcinoma is not fully clear. In this report, we focused on roles of expression silencing of ILK in multi-drug resistance reversal of human gastric carcinoma SGC7901/DDP cells, including increased drug sensitivity to cisplatin, cell apoptosis rates, and intracellular accumulation of Rhodamine-123, and decreased mRNA and protein expression of multi-drug resistance gene (MDR1), multi-drug resistanceassociated protein (MRP1), excision repair cross-complementing gene 1 (ERCC1), glutathione S-transferase -π (GST-π) and RhoE, and transcriptional activation of AP-1 and NF-κB in ILK silenced SGC7901/DDP cells. We also found that there was a decreased level of p-Akt and p-ERK. The results indicated that ILK might be used as a potential therapeutic strategy to combat multi-drug resistance through blocking PI3K-Akt and MAPK-ERK pathways in human gastric carcinoma.

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Cancer Trends in China

Cited by 277 publications

References 8 publications

A miRNAs panel promotes the proliferation and invasion of colorectal cancer cells by targeting GABBR1

A miRNAs panel promotes the proliferation and invasion of colorectal cancer cells by targeting GABBR1

Association Between MDM2 SNP309 T>G and Risk of Gastric Cancer: A Meta-analysis

Role of Integrin-Linked Kinase in Multi-drug Resistance of Human Gastric Carcinoma SGC7901/DDP Cells

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