Cancer survival in Kampala, Uganda

Gondos, Ádám; Brenner, Hermann; Wabinga, Henry; Parkin, D. Maxwell

doi:10.1038/sj.bjc.6602540

Cited by 136 publications

(125 citation statements)

References 60 publications

(53 reference statements)

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“…With the potential for increasing HCC rates after prolonged survival of effectively treated HIV-infected persons, continued HCC surveillance will be vital to monitor trends. Irrespective of gender, HCCs present at very advanced stages and are highly lethal (Gondos et al, 2005). Therefore, systematic investigation of HCC etiological factors in Uganda is needed to inform appropriate primary preventive interventions (e.g., hepatitis B vaccine, aflatoxin reduction programmes, dietary, or physical activity interventions to prevent obesity).…”

Section: Discussionmentioning

confidence: 99%

Trends in the incidence of primary liver cancer in Central Uganda, 1960–1980 and 1991–2005

et al. 2009

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Primary liver cancer (PLC) incidence trends from Africa are unknown. Using Kampala Cancer Registry data from 1960 to 1980 and 1991 to 2005, we identified 771 PLCs. Although rates were stable among men, PLC incidence among women increased >50%. Investigations of viral hepatitis, aflatoxin, obesity, and human immunodeficiency virus (HIV) may help to explain the increasing incidence of hepatocellular carcinomas (HCCs).

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Section: Discussionmentioning

confidence: 99%

Trends in the incidence of primary liver cancer in Central Uganda, 1960–1980 and 1991–2005

et al. 2009

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“…This is may be partially due to the short-life expectancy and young population structure of African women. However, the full spectrum of this phenomenon could relect complex gene-environment interactions associated with both traditional and new lifestyles in Africa [6,17,19,[28][29][30][31][32].…”

Section: Major Clinicopathological Features Of Breast Cancer In Sudanmentioning

confidence: 99%

Epidemiology, Pathology, Management and Open Challenges of Breast Cancer in Central Sudan: A Prototypical Limited Resource African Setting

Mariani–Costantini¹,

Elhassan²,

Aceto³

et al. 2017

Breast Cancer - From Biology to Medicine

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Litle is known about breast cancer in Sudan. According to the recent data published by the Khartoum Cancer Registry, breast cancer was the most common cancer among Sudanese women. Generally, breast cancer in native African women is characterized by young age at onset, occurrence in multiparous premenopausal patients, advanced stage at diagnosis, large tumor size, high-grade and triple-negative phenotype, with correspondingly poor prognosis. In Sudan, it was reported that about 70% of the women diagnosed with breast cancer were younger than 50 years old. We present here data from local and international publications as well as primary information from the National Cancer Institute in Wad Medani (one of the only two cancer hospitals of the country, both located in Central Sudan in Khartoum and Wad Medani). We provide an up-to-date situation analysis of breast cancer in Central Sudan as an example for an African reality and the various open challenges of breast cancer in a limited resource seting. A beter understanding of breast cancer in black African women is of global relevance, as there is an alarming increase in breast cancer among young black women worldwide, and these patients have the lowest survival rates.

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“…The Registry serves an area of about 1914 km 2 , which comprises of Kampala with neighbouring urban and semi-urban areas (Gondos et al, 2005) and an estimated population of 1.7 million in 2002 (Population Council, 2004). The population of females 415 years of age is about 530 000.…”

Section: Patient Seriesmentioning

confidence: 99%

Expression of aldehyde dehydrogenase 1 (ALDH1) is associated with basal-like markers and features of aggressive tumours in African breast cancer

et al. 2009

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BACKGROUND: Putative breast cancer stem cells might express surface markers such as aldehyde dehydrogenase 1 (ALDH1) and BMI-1 proteins. The aim of this study was to explore the expression of these proteins in breast cancers from an African population and their associations with the basal-like phenotype (BLP) and other molecular characteristics. METHODS: We analysed 192 paraffin-embedded breast carcinoma samples by tissue microarrays and immunohistochemical methods. RESULTS: In total, 88 tumours (48%) expressed ALDH1, whereas 46 (25%) expressed BMI-1 protein. Expression of ALDH1 was associated with high histological grade (Po0.0005), high mitotic count (Po0.0005), high nuclear grade (Po0.0005), oestrogen receptor (ER) negativity (Po0.0005), progesterone receptor (PR) negativity (P ¼ 0.009), p53 expression (P ¼ 0.034), cytokeratin 5/6 positivity (P ¼ 0.008), epidermal growth factor receptor (EGFR) expression (P ¼ 0.015) and the BLP (Po0.0005), whereas it was inversely associated with BMI-1 staining (P ¼ 0.009). On the other hand, BMI-1 expression was associated with low histological grade (P ¼ 0.004) and ER positivity (P ¼ 0.001). CONCLUSION: There was a high prevalence of ALDH1 expression among breast carcinomas and associations with basal markers and features of aggressive tumours. Studies are required to elucidate the importance of these findings for improved understanding of breast cancer biology.

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Cancer survival in Kampala, Uganda

Cited by 136 publications

References 60 publications

Trends in the incidence of primary liver cancer in Central Uganda, 1960–1980 and 1991–2005

Trends in the incidence of primary liver cancer in Central Uganda, 1960–1980 and 1991–2005

Epidemiology, Pathology, Management and Open Challenges of Breast Cancer in Central Sudan: A Prototypical Limited Resource African Setting

Expression of aldehyde dehydrogenase 1 (ALDH1) is associated with basal-like markers and features of aggressive tumours in African breast cancer

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