Cancer Stem Cells Accountability in Progression of Head and Neck Squamous Cell Carcinoma: The Most Recent Trends!

Routray, Samapika; Mohanty, Neeta

doi:10.1155/2014/375325

Cited by 25 publications

(23 citation statements)

References 57 publications

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“…The number of tissue‐specific stem cells is lower when compared to other cells. This is consistent with the hypothesis that the CSC has their origin in the specific tissue stem cells . We have identified a distinct ALDH + and ALDH − population of HNSCC tumours.…”

Section: Discussionsupporting

confidence: 92%

“…In accordance with the American Association for Cancer Research (AACR), neoplastic stem cells or CSC are defined as cells from the tumour with capacity to self‐renewal as well as to differentiate into various types of cells of the same line, ensuring phenotypic heterogeneity of the tumour. According to the “cancer stem cell hypothesis,” malignant stem cells are located at the top of the tumour cell hierarchy, as they are the only ones that exhibit proliferative properties …”

Section: Discussionmentioning

confidence: 99%

“…With our results, it was possible to determine the original relationship of the ALDH + CSC and the tumour cells. Fifty per cent of the samples presented a model of tumour evolution from a group of CSC precursors from which the tumour cells would drive; this model has been described in a large number of articles (Figure ). Only one sample showed a quite different model, where the both cell populations could have a common origin in a previous cancer cell, from which analysed stem cells and tumour cells would evolve in independent pathways.…”

Section: Discussionmentioning

confidence: 99%

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Whole exome sequencing approach to analysis of the origin of cancer stem cells in patients with head and neck squamous cell carcinoma

Salazar-García

Pérez‐Sayáns

García‐García

et al. 2018

J Oral Pathology Medicine

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Whole exome sequencing approach to analysis of the origin of cancer stem cells in patients with head and neck squamous cell carcinoma

Salazar-García

Pérez‐Sayáns

García‐García

et al. 2018

J Oral Pathology Medicine

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“…There are several signaling pathways (Notch, Wnt/β-Catenin, and Sonic Hedgehog) and molecules (Oct-4, bone morphogenic protein) that regulate self-renewal ability of cancer stem cells and maintain stem cell proliferation (Pazarbaşı et al, 2011;Routray and Mohanty, 2014). The core stem cell signaling pathways Hh, Wnt, and Notch are deregulated in most cancers and act as survival pathways for CSCs (Ponti et al, 2006;Song et al, 2007).…”

Section: Signaling Pathways In Cscsmentioning

confidence: 99%

“…EMT is a biological process enabling epithelial cells to acquire a migrant mesenchymal phenotype and is currently viewed as one of the essential steps during metastasis (Gupta and Massagué, 2006;Routray and Mohanty, 2014). In this process, epithelial cells lose cell-cell adhesion and cell polarity and decrease the expression of epithelial cells markers while upregulating mesenchymal markers such as vimentin, N-cadherin, and fibronectin.…”

Section: Cscs and Emtmentioning

confidence: 99%

Cancer stem cells: emerging actors in both basic and clinical cancer research

Karakaş¹,

Cevatemre²,

Ulukaya

2014

Turk J Biol

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IntroductionOver the past 50 years, many disease that cause death have dramatically decreased. Nevertheless, cancer deaths continue (Leaf, 2013). The International Agency for Research on Cancer, the specialized cancer agency of the World Health Organization, released the latest data on cancer incidence, mortality, and prevalence worldwide (Ferlay et al., 2013). According to GLOBOCAN 2012, an estimated 14.1 million new cancer cases and 8.2 million cancer-related deaths occurred in 2012, compared with 12.7 million and 7.6 million in 2008, respectively. The most commonly diagnosed cancers worldwide were those of the lung (13% of the total), breast (11.9%), and colorectum (9.7%). The most common causes of cancer death were cancers of the lung (19.4% of the total), liver (9.1%), and stomach (8.8%). GLOBOCAN 2012 predicted a substantive increase to 19.3 million new cancer cases per year by 2025 due to growth and aging of the global population (Ferlay et al., 2013). Despite these statistics, the ability to specifically target pathways altered in cancer raises the hope of developing therapies with high specificity and low toxicity. Therefore, it is important to target the 'right cells' (Wicha et al., 2006).A large body of evidence is accumulating to indicate that most, if not all, malignancies can be viewed as abnormal organs with a stem cell compartment that drives the growth. Furthermore, besides tumor initiation, these tumor-initiating cells, also referred to as cancer stem cells (CSCs), are thought to be responsible for metastasis, recurrence, and drug resistance (Chen K et al., 2013). The CSC hypothesis has fundamental implications for understanding the biology of carcinogenesis as well as for developing new strategies for cancer prevention and eradication of malignancies. Characteristics of CSCsCSCs are cancer cells that possess characteristics associated with normal stem cells. At the molecular level, CSCs and normal stem cells share some common features, including the capacity for self-renewal (Reya et al., 2001), the ability to differentiate, active telomerase expression, activation of antiapoptotic pathways, increased membrane transporter activity, and the ability to migrate and metastasize (Wicha et al., 2006). In addition to these properties, they display an anchorage-independent survival, active DNA-repair capacity, and relative quiescence (slow cell cycling) (Dean et al., 2005;Wicha et al., 2006). Concept of CSCsWhere CSCs come from is an intensely researched question. Some researchers suggest that CSCs may originate from mutated normal stem cells upon aberrant alteration of the self-renewal pathways (Reya et al., 2001). An alternative hypothesis is that CSCs originate from differentiated cells that have acquired stem-like features following Abstract: Cancer stem cells (CSCs) are a small subset of cancer cells within a tumor that are responsible for tumorigenesis and contribute to drug resistance. The CSC displays an anchorage-independent survival, active DNA-repair capacity, and relative quiescence and is ...

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Immunolocalization of Cancer Stem Cells Marker ALDH1 and its Association with Tumor Budding in Oral Squamous Cell Carcinoma

Júnior

Melo

Caixeta

et al. 2018

Head and Neck Pathol

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Tumor budding is a prognostic marker for oral squamous cell carcinoma (OSCC) characterized by the presence of isolated or small clusters of neoplastic cells at the tumor invasive front. Aldehyde dehydrogenase-1 (ALDH1) is associated with tumorigenesis, linked to treatment resistance and shown to identify cancer stem cells (CSC)-like cells. This study aimed to evaluate the expression of ALDH1 and its association with tumor budding in OSCC. Immunohistochemistry was employed in 163 OSCC samples to identify pancytokeratin (AE1/AE3) and ALDH1. While pancytokeratin (AE1/AE3) identified squamous tumor buds, the CSC-like cells were identified using ALDH1. A Chi square test was used to evaluate association between ALDH1 expression and tumor budding, while McNemar's test was used to identify differences in ALDH1 expression between the budding area and the area outside the budding. A positive expression of ALDH1 was observed in 47.24% of the samples and in 70% of anatomic locations affected. No association was observed between ALDH1 expression and tumor budding (p > 0.05). In tumors with high-intensity tumor budding, ALDH1 expression was higher in the budding area than in the area outside the budding (p < 0.05). The finding that tumor bud cells in OSCC show phenotypic characteristics of CSC-like cells reinforces the relevance of tumor budding in determining the biological behavior of this malignant neoplasm. Moreover, the presence of CSC-like cells in nearly half of evaluated samples of OSCC and in most of the affected anatomic locations is in accordance with the CSC model of oral carcinogenesis.

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Cancer Stem Cells Accountability in Progression of Head and Neck Squamous Cell Carcinoma: The Most Recent Trends!

Cited by 25 publications

References 57 publications

Whole exome sequencing approach to analysis of the origin of cancer stem cells in patients with head and neck squamous cell carcinoma

Whole exome sequencing approach to analysis of the origin of cancer stem cells in patients with head and neck squamous cell carcinoma

Cancer stem cells: emerging actors in both basic and clinical cancer research

Immunolocalization of Cancer Stem Cells Marker ALDH1 and its Association with Tumor Budding in Oral Squamous Cell Carcinoma

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