Cancer Statistics, 1976 A Comparison of White and Black Populations

Seidman, Herbert; Silverberg, Edwin; Holleb, Arthur I.

doi:10.3322/canjclin.26.1.2

Cited by 34 publications

(9 citation statements)

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“…In contrast to the trend for the United States,5 6 we observed a greater increase in the rates for whites than for nonwhites. Changes in age composition did not contribute to the observed increases in Louisiana, when compared with the rest of the nation nor when compared with the previous data period, because rates were adjusted to the same (1960) U.S. age distribution.…”

Section: Discussioncontrasting

confidence: 99%

Trends in respirator system cancer mortality in Louisiana: geographic distributions in 1950-1969 and 1967-1976 compared.

Rothschild¹,

Voors²,

Weed³

et al. 1979

Am J Public Health

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Section: Discussioncontrasting

confidence: 99%

Trends in respirator system cancer mortality in Louisiana: geographic distributions in 1950-1969 and 1967-1976 compared.

Rothschild¹,

Voors²,

Weed³

et al. 1979

Am J Public Health

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“…The incidence of breast cancer in the American Negro is less than in the American Caucasian, but the gap seems to be closing [10,11], Our data does not support or exclude the apparent lower incidence in Blacks and Orientals, because the utilization rate is not determined. However, it is clear that menopause has …”

Section: Racecontrasting

confidence: 67%

Risk Factors in Breast Cancer: Are They Important, Are They the Same in Pre- and Post-Menopausal Breast Cancer Patients

Frankl¹

1980

Oncology

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The information derived from the mammographic history questionnaires of 450 breast cancer patients was collated and separated, comparing 332 post-menopausal and 118 pre-menopausal breast cancer patients. Our observations confirm the importance of risk factors in the development of breast cancer and show the similarity in the incidence of certain risk factors among pre- and post-menopausal breast cancer patients.

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“…Several examples include the higher prevalence of decreased intestinal lactase activity in blacks (20), the increased percentage of blacks with erythrocyte glucose-6-phosphate dehydrogenase deficiency (21), and the variable prevalence rates of many types of neoplasia between races (22). More relevant to our own results, there are experimental and epidemiologic reports that suggest fundamental differences between blacks and whites with primary hypertension.…”

Section: Resultsmentioning

confidence: 56%

Urinary kallikrein and plasma renin activity as determinants of renal blood flow. The influence of race and dietary sodium intake.

Levy¹,

Lilley²,

Frigon³

et al. 1977

J. Clin. Invest.

233

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A B S T R A C T We investigated the relationship of the kallikrein-kinin system and the renin-angiotensin system in the regulation of blood pressure, salt and water excretion, and renal blood flow. Normotensive and hypertensive black and white men were studied during unrestricted sodium intake as well as on a 10-meq/day sodium intake; potassium intake was held constant throughout the study (80 meq/day).During unrestricted sodium intake, urinary kallikrein activity was greater in white normotensives than white hypertensives or black normotensives. There was no difference (P > 0.05) between white and black hypertensives or between black normotensives and black hypertensives. All groups had greater urinary kallikrein activity on low sodium vs. unrestricted sodium intake, but the increase in black hypertensives was small, and they excreted significantly less kallikrein than the other groups on the low sodium diet. Plasma renin activity showed similar increments after sodium restriction in all groups. Urinary kallikrein activity correlated with renal blood flow in all groups except the black normotensives on low sodium intake. Renal blood flow could be correlated uniformly with log (urinary kallikrein activity/supine plasma renin activity) in all groups on either diet. Urinary sodium and potassium excretion and urine volume were not different among the groups. We concluide: (a) support the concept that the kallikrein-kinin system and the renin-angiotensin system contribute to the regulation of renal blood flow and may account for racial differences in renal vascular resistance. INTRODUCTIONKallikrein is an enzyme that catalyzes the formation of the vasodilator hormones, lysyl-bradykinin (kallidin) and bradykinin, from a plasma alpha-2 globulin substrate, kininogen (1). Urinary kallikrein appears to be derived from the kidney and differs from the enzyme that circulates in plasma (2). It has been proposed that kallikrein exists in the renal cortex and may occupy a location that is juxtaposed to the enzyme renin (3). Although a physiologic function for lysyl-bradykinin, the enzymatic product, has not been established, pharmacologic infusion studies have shown that the peptide is a natriuretic and vasodilatory compound (4).A number of studies in humans and experimental animals have attempted to determine the relationship between urinary kallikrein activity and blood pressure regulation (5-9). Although most investigators feel that kallikreins could influence blood pressure, the meaning of these findings is controversial. Based on provocative preliminary observations (10) and the aforementioned studies, it seemed appropriate to examine the simultaneous influence of race and blood pressture on urinary kallikrein activity. In addition, we have examined the association between kallikrein in uirine and factors that have been related to blood pressure regulation including urinary volume, soditum excretion, plasma renin activity, and renal blood flow. These latter studies were designed to determine a possible physiologic role ...

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Cancer Statistics, 1976 A Comparison of White and Black Populations

Cited by 34 publications

References 0 publications

Trends in respirator system cancer mortality in Louisiana: geographic distributions in 1950-1969 and 1967-1976 compared.

Trends in respirator system cancer mortality in Louisiana: geographic distributions in 1950-1969 and 1967-1976 compared.

Risk Factors in Breast Cancer: Are They Important, Are They the Same in Pre- and Post-Menopausal Breast Cancer Patients

Urinary kallikrein and plasma renin activity as determinants of renal blood flow. The influence of race and dietary sodium intake.

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