Cancer-Specific Mortality and Competing Mortality in Patients with Head and Neck Squamous Cell Carcinoma: A Competing Risk Analysis

Shen, Weidong; Sakamoto, Naoko; Yang, Limin

doi:10.1245/s10434-014-3951-8

Cited by 71 publications

(100 citation statements)

References 31 publications

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“…Among patients younger than 55 years old, those aged 35-44 had the best survival. Age was found to be an important prognostic factor in several studies [18, 19, 22], although the reason for this is currently unclear. The mortality rates of black HNSCC patients were higher than that of other races.…”

Section: Discussionmentioning

confidence: 99%

“…Nomogram development is also included in the NCCN guidelines [17]. One HNSCC study based on the Surveillance, Epidemiology and End Results (SEER) database between 2000 and 2010 applied nomograms [18], but TNM stage information was not available in the database until 2004, and this study did not include patients without surgery. We aimed to develop HNSCC nomograms predicting long-term OS and CSS based on multiple clinicopathologic factors, as well as TNM stage, to improve individual patient treatments and follow-up strategies.…”

Section: Introductionmentioning

confidence: 99%

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Nomograms predicting long-term overall survival and cancer-specific survival in head and neck squamous cell carcinoma patients

Jia

et al. 2016

Oncotarget

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This study aimed to develop nomograms to predict long-term overall survival and cancer-specific survival in patients with head and neck squamous cell carcinoma (HNSCC). We conducted prognostic analyses and developed nomograms predicting survival outcome using HNSCC patient data collected from the Surveillance, Epidemiology and End Results (SEER) program of the National Cancer Institute. An external dataset of 219 patients was used to validate the nomograms. Of 36,179 HNSCC patients, 9,627 (26.6%) died from HNSCC and 4,229 (11.7%) died from other causes. Median follow-up was 28 months (1-107 months). Nomograms predicting overall survival (OS) and cancer-specific survival (CSS) were developed according to 10 clinicopathologic factors (age, race, sex, tumor site, tumor grade, surgery, radiotherapy and TNM stage), with concordance indexes (C-indexes) of 0.719 and 0.741, respectively. External validation C-indexes were 0.709 and 0.706 for OS and CSS, respectively. Our results suggest that we successfully developed nomograms predicting five- and eight-year HNSCC patient OS and CSS with high accuracy. These nomograms could help clinicians tailor surgical, adjuvant therapeutic and follow-up strategies to more effectively treat HNSCC patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nomograms predicting long-term overall survival and cancer-specific survival in head and neck squamous cell carcinoma patients

Jia

et al. 2016

Oncotarget

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“…Radiotherapy and Oncology xxx (2015) xxx-xxx HNSCC remains a challenge in oncology since its incidence exceeds half a million cases annually, representing the fifth leading cancer worldwide [1,2]. Despite treatment improvements, 40-50% of patients treated for HNSCC experience recurrence [3].…”

Section: Introductionmentioning

confidence: 99%

The radiosensitizing activity of the SMAC-mimetic, Debio 1143, is TNFα-mediated in head and neck squamous cell carcinoma

Matzinger

Viertl

Tsoutsou

et al. 2015

Radiotherapy and Oncology

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“…Worldwide, head and neck carcinomas are the 6 th most common cancer with an incidence of 400,000–500,000 annual cases, 1–5 and nearly $3.2 billion in treatment costs. Even with aggressive treatment, there is significant morbidity and mortality.…”

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confidence: 99%

Association of periodontitis and human papillomavirus in oral rinse specimens

Wiener¹,

Sambamoorthi²,

Jurevic³

2015

The Journal of the American Dental Association

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Background-Human papillomavirus (HPV) positive oropharyngeal squamous cell carcinomas are increasing in incidence and are becoming significant public health concerns. Periodontitis is a chronic condition in which the affected tissue may facilitate oral HPV infection and persistence. The purpose of this study was to determine if an association of the presence of HPV in oral rinse specimens and periodontal disease exists.

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Cancer-Specific Mortality and Competing Mortality in Patients with Head and Neck Squamous Cell Carcinoma: A Competing Risk Analysis

Abstract: We constructed competing risk nomograms for HNSCC using population-based data. The model used for building nomograms represented good performance. These nomograms can serve to guide management of patients with HNSCC.

Cited by 71 publications

References 31 publications

Nomograms predicting long-term overall survival and cancer-specific survival in head and neck squamous cell carcinoma patients

Nomograms predicting long-term overall survival and cancer-specific survival in head and neck squamous cell carcinoma patients

The radiosensitizing activity of the SMAC-mimetic, Debio 1143, is TNFα-mediated in head and neck squamous cell carcinoma

Association of periodontitis and human papillomavirus in oral rinse specimens

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