Association of periodontitis and human papillomavirus in oral rinse specimens

Wiener, R. Constance; Sambamoorthi, Usha; Jurevic, Richard J.

doi:10.1016/j.adaj.2015.01.019

Cited by 22 publications

(26 citation statements)

References 34 publications

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“…Taken together, we found that the Han nationality, average monthly income, and the time needed to reach the nearest town hospital have significant effects on health care-seeking delay and proved that the accessibility of health services may affect health care-seeking behavior [ 36 , 37 , 38 ]. However, we did not find a strong link between sex, age, and literacy, and treatment delay, somewhat at variance with other studies [ 39 , 40 , 41 , 42 , 43 , 44 ]. It is worth noting that we should strengthen TB control in remote areas, particularly the areas with unsound medical systems.…”

Section: Discussioncontrasting

confidence: 89%

Determinants of Health Care-Seeking Delay among Tuberculosis Patients in Rural Area of Central China

Tong

Guan

Hou

et al. 2018

IJERPH

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Background The prevalence of tuberculosis (TB) in low and middle-income countries is a significant public health and social concern. TB is a common infectious disease caused by the Mycobacterium tuberculosis infection, which has a widespread infection rate. Health care-seeking delay maybe one of the most important neglected risk factors for the spread of TB. Objectives The aim of this study was to understand the situation of health care-seeking delay among rural tuberculosis patients in Hubei Province, and explore its risk factors. Methods A total of 1408 rural tuberculosis patients were surveyed using a standard structured questionnaire in three cities of Hubei Province during the past two years. Results For the 1408cases of pulmonary tuberculosis, 39.70% of them were health care-seeking delayed. Logistic regressions indicate that the Han nationality, farming careers, the over 45 min walk to the township’s hospital, and awareness of the national TB free treatment policy, were significantly associated with higher odds of a delay in care seeking. Conclusions The prevalence of health care-seeking delay among tuberculosis patients was high in rural areas. It is essential to take comprehensive targeted interventions to reduce care-seeking delay.

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Section: Discussioncontrasting

confidence: 89%

Determinants of Health Care-Seeking Delay among Tuberculosis Patients in Rural Area of Central China

Tong

Guan

Hou

et al. 2018

IJERPH

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“…In this study, HPV DNA was easily detected in the healthy population in cells obtained from apparently normal oral mucosa using an average of 50 ng genomic DNA, as suggested by [14]. Moreover, according to these results, specimens collected using brush cytology resulted as good as those obtained using oral gargle, since the prevalence of oral HPV infection remained almost identical to that reported in other studies [11,[15][16][17]. Any oral exfoliative cytological procedure capable of reducing false negative or false positive results would support the method as a more effective tool to screen for oral pre-cancer or cancer lesion, and for other specific viral diseases; the finding that recent tooth-brushing increases HPV detection also suggests that the current sampling techniques may be improved by epithelial scraping [18] Recent studies suggest that oral HPV prevalence is substantially lower than genital HPV infection (D'Souza et al and Read et al) and greatly fluctuating in normal oral mucosa because of differences in sample types, sample collection methods, sample quantitation, level of sensitivity, PCR primer specificity and/or presence of PCR inhibitors [14,19].…”

Section: Discussionsupporting

confidence: 82%

Identification of Human Papilloma Virus (HPV) in the Oral Cavity of Asymptomatic Colombian Men

Vargas¹,

DM²,

SL³

2015

Mol Biol

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HPV infection is currently associated with the risk of lesions in the oral cavity and the oropharynx and has been recognized as a possible etiologic agent of a set of head and neck cancers. However, the detection of HPV in healthy individuals is rare, and little is known about the HPV types present in the oral cavity. A variety of sampling methods has been proposed to increase the sensitivity of viral detection, mostly intended to detect HPV in the oropharynx. Here we estimated the prevalence of HPV in 66 samples of healthy mucosa from the oral cavity of Colombian sexually active men using a liquid-based cytology strategy for sample collection. Generic HPV detection was performed by PCR using a fragment of the β-globin gene as a quality control for the isolated DNA. Type-specific detection was performed with the commercial linear array technique (Roche, USA). All oral samples were positive for β-globin gene. Overall HPV prevalence was 4.5% (3/66); one sample corresponded to HPV16, another was genotyped as HPV11 and the third could not be genotyped and was classified as undetermined. The prevalence of HPV in the oral cavity of asymptomatic men is consistent with that reported worldwide for oropharyngeal cancer. Despite the small sample size, this is the first study that detected HPV in the healthy oral cavity of Colombian men.

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“…It has been speculated that an inflamed periodontal pocket serves as a reservoir for HPV and induces HPV infection (19). Whether periodontal disease is related to oral HPV infection remains controversial (20)(21)(22), though the presence of such inflammatory diseases may serve an important role in the biology of HPV infection. On the other hand, HPV may be involved in deterioration associated with periodontal disease (i.e., increased alveolar bone loss) in accordance with other pathogenic factors (18).…”

Section: Discussionmentioning

confidence: 99%

High HPV16 E6 viral load in the oral cavity is associated with an increased number of bacteria: A preliminary study

et al. 2017

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Abstract. In a previous study, the present research group reported that males had a significantly higher prevalence of human papillomavirus (HPV)16 than females in oral rinse samples. The objective of the present study was to examine the relationship between HPV16 viral load and clinical factors, including remaining teeth, denture use and numbers of oral bacteria. A total of 124 patients (48 males and 76 females; mean age, 61.6 years; age range, 20-97 years) who visited the Department of Oral and Maxillofacial Reconstructive Surgery of Hiroshima University Hospital (Hiroshima, Japan) between November 2016 and August 2017 were analyzed. None of the patients had evidence of oral cancer or pre-malignant lesions, including epithelial dysplasia and leukoplakia. Quantitative polymerase chain reaction (qPCR) analysis was employed to examine the number of HPV16 viral copies. Furthermore, the number of oral bacteria was determined using the dielectrophoretic impedance measurement method. HPV16 was below the limit of detection in qPCR findings for samples obtained from 30 of the 124 subjects, thus the association of HPV16 viral copy number with clinical parameters was examined in the remaining 94 patients. The average number of HPV16 E6 DNA copies was 1.65±3.47 copies/cell (range, 0.07-25.3 copies/cell) and was significantly higher in subjects with a high oral bacteria count [≥10 6.5 colony forming unit (CFU)/ml] than in those with a low count (<10 6.5 CFU/ml) (0.79±0.98 vs. 2.06±4.11 copies/cell; P=0.030). The present results indicated that HPV16 viral load may be related to an increased bacterial number in the oral cavity. Further investigations are required to clarify the correlation between oral HPV load and oral hygiene status. IntroductionHuman papillomavirus (HPV) infection is a major cause of cervical cancer and is also associated with the development of oropharyngeal cancer and prognosis in affected patients (1-3). To date, >170 HPV genotypes have been reported, of which ~50 are known to infect the anogenital and oral mucosa regions (4-6). As for oral cancer, a previous study conducted by the present research group indicated that ~80% of patients with HPV16-positive moderate epithelial dysplasia progressed to oral squamous cell carcinoma (OSCC), indicating that oral HPV16 infection may also be associated with the development of oral cancer (7). However, few epidemiologic studies have focused on oral HPV prevalence in non-OSCC cases and the risk factors for oral HPV infection have not been fully elucidated. Hence, we previously performed a meta-analysis, which demonstrated that sexual behavior and smoking are significant risk factors for oral HPV infection in cancer-free individuals (8). In addition, other factors, such as poor oral hygiene related to periodontitis and gingivitis, have been indicated to be associated with oral HPV infection (8).In order to examine the correlation between HPV16 prevalence in the oral cavity and clinical factors, we also investigated HPV16 prevalence using oral rinse samples obtaine...

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Association of periodontitis and human papillomavirus in oral rinse specimens

Cited by 22 publications

References 34 publications

Determinants of Health Care-Seeking Delay among Tuberculosis Patients in Rural Area of Central China

Determinants of Health Care-Seeking Delay among Tuberculosis Patients in Rural Area of Central China

Identification of Human Papilloma Virus (HPV) in the Oral Cavity of Asymptomatic Colombian Men

High HPV16 E6 viral load in the oral cavity is associated with an increased number of bacteria: A preliminary study

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