Cancer serum index: A useful nonspecific test as a parameter in multimodality screening and assessment of patients with cancer of the prostate

Kundin, W. D.; Mechali, P; Hollinshead, Ariel C.; Miller, Helen C.; Bensimon, Hector

doi:10.1002/pros.2990020209

Cited by 7 publications

(5 citation statements)

References 20 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The changes in the APRPs are triggered by some cytokines, including tumor necrosis factor-a (TNF-a) and interleukins -1 and -6 (5, 6). a 1 -Acid glycoprotein was used for pre-operative detection of fixation of colorectal tumors (8), detecting and monitoring the therapy of lung cancer (9), and screening and assessment of prostate cancer (10). Walker and Gray showed that APRPs have a higher diagnostic rate for the presence of primary malignancies of the large bowel than does carcinoembryonic antigen (7).…”

Section: Introductionmentioning

confidence: 99%

Serum proteins profile as an indicator of malignancy: multivariate logistic regression and ROC analyses

Rasouli¹,

Okhovatian²,

Enderami³

2005

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

The electrophoretic pattern of serum proteins of 85 patients carrying different types of neoplasia and 85 matched healthy adults were comparatively studied by agarose gel electrophoresis, to find out if there is a specific protein pattern common to different types of cancer. Each protein fraction was analyzed quantitatively by densitometry. Multivariate logistic regression and receiver operating characteristic (ROC) analyses were performed using SPSS software. When total protein and albumin were measured by colorimetric methods, cancer patients, compared to controls, had a decreased concentration of total protein (66.0+/-11.5 g/L vs. 76.4+/-6.8 g/L, p< or =0.0001) and of albumin (39.0+/-8.1 g/L vs. 46.0+/-4.3 g/L, p< or =0.0001). The electrophoretic data of serum proteins showed that the ratio of albumin to globulin (0.92+/-0.30 vs. 1.21+/-0.16, p< or =0.0001), percent of the fractions albumin (46.7+/-8.5% vs. 54.4+/-3.5%, p< or =0.0001) and beta-globulin (11.6+/-4.4% vs. 13.0+/-1.9%, p< or =0.001) were decreased and alpha(1)- (5.3+/-2.5% vs. 2.9+/-0.8%, p< or =0.0001), alpha(2)- (13.5+/-4.8% vs. 11.3+/-2.1%, p< or =0.0001) and gamma-globulins (23.0+/-7.7% vs. 18.3+/-3.1%, p< or =0.0001) were significantly increased in cancer patients relative to controls. Cancer patients also had higher counts of leukocytes (7.98+/-3.11, x10(9) cells/L vs. 6.33+/-1.68 x10(9) cells/L, p< or =0.0001) and erythrocyte sedimentation rate (35.9+/-23.5 mm/h vs. 14.1+/-9.5 mm/h,p< / =0.0001). On the basis of univariate analysis, a protein profile out of the normal ranges was more prevalent in cancer patients than in controls. Analysis of the data using multiple logistic regression indicated that the prevalence of cancer was strongly associated with the serum proteins' profile, and alpha(1)-globulin, erythrocyte sedimentation rate, total protein and the ratio of albumin to globulin were the best parameters to discriminate between malignant and healthy states. The area under the ROC curves were the same for most components of the serum proteins' profile at about 0.75+/-0.09, p< or =0.001. We conclude that the profile of serum proteins indicates high diagnostic values for discriminating between cancer patients and healthy individuals and may be useful as an adjunct diagnosis for detection of malignancy.

show abstract

Section: Introductionmentioning

confidence: 99%

Serum proteins profile as an indicator of malignancy: multivariate logistic regression and ROC analyses

Rasouli¹,

Okhovatian²,

Enderami³

2005

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

show abstract

“…The KDOQI Clinical Practice Guidelines for Nutrition in Chronic Renal Failure suggest that AGP may be more specific than CRP for detecting inflammation in MD patients [32]. In our previous study [18], we calculated a prognostic inflammatory and nutritional index (PINI), a clinical assessment tool which aggregates serum CRP, AGP, prealbumin, and albumin concentrations into a single score [35], cancer serum index (CSI) [36], and prealbumin to CRP ratio to account for the multifactorial complexity of malnutrition in HD patients.…”

Section: Discussionmentioning

confidence: 99%

α1-Acid Glycoprotein and Dietary Intake in End-Stage Renal Disease Patients

et al. 2021

View full text Add to dashboard Cite

Management of end-stage renal disease (ESRD) patients requires monitoring each of the components of malnutrition–inflammation–atherosclerosis (MIA) syndrome. Restrictive diet can negatively affect nutritional status and inflammation. An acute-phase protein—α1-acid glycoprotein (AGP), has been associated with energy metabolism in animal and human studies. The aim of our study was to look for a relationship between serum AGP concentrations, laboratory parameters, and nutrient intake in ESRD patients. The study included 59 patients treated with maintenance hemodialysis. A 24 h recall assessed dietary intake during four non-consecutive days—two days in the post-summer period, and two post-winter. Selected laboratory tests were performed: complete blood count, serum iron, total iron biding capacity (TIBC) and unsaturated iron biding capacity (UIBC), vitamin D, AGP, C-reactive protein (CRP), albumin, prealbumin, and phosphate–calcium metabolism markers (intact parathyroid hormone, calcium, phosphate). Recorded dietary intake was highly deficient. A majority of patients did not meet recommended daily requirements for energy, protein, fiber, iron, magnesium, folate, and vitamin D. AGP correlated positively with CRP (R = 0.66), platelets (R = 0.29), and negatively with iron (R = −0.27) and TIBC (R = −0.30). AGP correlated negatively with the dietary intake of plant protein (R = −0.40), potassium (R = −0.27), copper (R = −0.30), vitamin B6 (R = −0.27), and folates (R = −0.27), p < 0.05. However, in multiple regression adjusted for confounders, only CRP was significantly associated with AGP. Our results indicate that in hemodialyzed patients, serum AGP is weakly associated with dietary intake of several nutrients, including plant protein.

show abstract

“…Although a certain level of ORM is present in plasma of healthy individuals [5, 6], the amount of the substance markedly elevates in patients with metastatic tumors and in severely burned patients [7-13], who are immensely susceptible to various opportunistic infections [14-16]. Similarly, these patients are known to be carriers of M2 macrophages [33, 37], which inhibit host antibacterial innate immunities [33, 38].…”

Section: Discussionmentioning

confidence: 99%

“…As compared to healthy individuals, the plasma levels of ORM in cancer patients [7, 8] and thermally injured patients [9-13] are greatly increased, and these patients are shown to be susceptible to various opportunistic infections [14-16]. ORM has been described as an inducer of M2 macrophages [17-23], which play a major role in the increased susceptibility of these patients to opportunistic infections.…”

Section: Introductionmentioning

confidence: 99%

Orosomucoid 1 drives opportunistic infections through the polarization of monocytes to the M2b phenotype

et al. 2015

View full text Add to dashboard Cite

Orosomucoid (ORM, composed of two isoforms, ORM1 and ORM2) has been described as an inducer of M2 macrophages, which are cells that decrease host antibacterial innate immunities. However, it is unknown which phenotypes of M2 macrophages are induced by ORM. In this study, healthy donor monocytes stimulated with ORM (ORM-monocytes) were characterized phenotypically and biologically. CCL1 (a biomarker of M2b macrophages) and IL-10 were detected in monocyte cultures supplemented with ORM1; however, CCL17 (a biomarker of M2a macrophages) and CXCL13 (a biomarker of M2c macrophages) were not produced in these cultures. All of these soluble factors were not detected in the culture fluids of monocytes stimulated with ORM2. Monocytes stimulated with ORM1 were characterized as CD64−CD209−CD163+CCL1+ cells. MRSA and Enterococcus faecalis infections were accelerated in chimeras (NOD/scid IL-2Rγnull mice reconstituted with white blood cells) after inoculation with monocytes stimulated with ORM1 or treatment with ORM1; however, the infections were greatly mitigated in both chimeras inoculated with ORM1-stimulated monocytes and treated with ORM1, after an additional treatment with an inhibitor of M2b macrophages (CCL1 antisense ODN). These results indicate that ORM1 stimulates quiescent monocytes to polarize to M2b monocytes. The regulation of M2b macrophages may be beneficial in controlling opportunistic infections in patients with a large amount of plasma ORM1.

show abstract

Cancer serum index: A useful nonspecific test as a parameter in multimodality screening and assessment of patients with cancer of the prostate

Cited by 7 publications

References 20 publications

Serum proteins profile as an indicator of malignancy: multivariate logistic regression and ROC analyses

Serum proteins profile as an indicator of malignancy: multivariate logistic regression and ROC analyses

α1-Acid Glycoprotein and Dietary Intake in End-Stage Renal Disease Patients

Orosomucoid 1 drives opportunistic infections through the polarization of monocytes to the M2b phenotype

Contact Info

Product

Resources

About