Cancer risk in tuberculosis patients in a high endemic area

Chen, Guang-Liang; Guo, Li; Yang, Shuai; Ji, Dongmei

doi:10.1186/s12885-021-08391-6

Cited by 16 publications

(13 citation statements)

References 36 publications

(48 reference statements)

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“…Notably, a recent case-control study showed that patients with TB have an elevated cancer risk of cervical cancer, possibly due to chronic inflammation, but the etiopathogenesis has not been fully elucidated. 38 Hence, the association between TB and cervical cancer requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Risk factors and communities disproportionately affected by cervical cancer in the Russian Federation: A national population-based study

Muntyanu¹,

Nechaev²,

Pastukhova³

et al. 2022

The Lancet Regional Health - Europe

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Section: Discussionmentioning

confidence: 99%

Risk factors and communities disproportionately affected by cervical cancer in the Russian Federation: A national population-based study

Muntyanu¹,

Nechaev²,

Pastukhova³

et al. 2022

The Lancet Regional Health - Europe

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“…On the other hand, a number of studies have revealed that TB patients have an increased risk of cancer, including some types of extrapulmonary cancer. [10][11][12] Cancer may develop as a result of chronic inflammation at local and systemic levels of TB infection, and populations with TB infection and certain types of cancer may share some common risk factors.…”

Section: Discussionmentioning

confidence: 99%

Recurrent choriocarcinoma complicated with leprosy during chemotherapy: A case report and literature review

Lin

Yin

et al. 2023

Medicine

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Rationale: The global prevalence of leprosy has decreased substantially, and cases of leprosy infection are extremely rare in China. In this report, we present a case of recurrent choriocarcinoma complicated by leprosy infection during chemotherapy. Patient concerns: A 24-year-old Chinese woman (gravida 3, para 2) presented to a local hospital with vaginal bleeding. Her medical history included a previous diagnosis of hydatidiform mole. Diagnoses, Interventions and Outcomes: The patient was diagnosed with choriocarcinoma and received chemotherapy in 6 cycles. Shortly after the initial treatment was completed, the disease recurred twice with resistance to multiple chemotherapeutic agents. In her second recurrence of choriocarcinoma, she was diagnosed with leprosy with many cutaneous nodules throughout her entire body. The patient was administered chemical treatment for leprosy with the multidrug therapy regimen after being diagnosed. To prevent exacerbating the infection, no immunotherapy was utilized to treat cancer, and the infection was well-controlled at the conclusion of anticancer therapy. Lessons: Because of immunological reduction, cancer patients are susceptible to a variety of infections. For patients with cancer, prevention and early detection of rare infectious diseases should receive special attention. Immunotherapy must be used with caution when treating patients with cancer and infections.

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“…In addition, increased BMI does not seem to impact on survival of PB-DLBCL. Indeed, the risk and death of DLBCL patients are largely affected by chronic infection, 39 , 40 , 41 , 42 , 43 , 44 including hepatitis B virus infection. 45 , 46 , 47 However, our data found that HBsAg-positive status is not associated with OS (p=0.094).…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Prognostic Factors in Primary Breast Diffuse Large B-Cell Lymphoma

Chen

Li²,

Sufen³

et al. 2022

Mediterr J Hematol Infect Dis

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Background Primary breast diffuse large B-cell lymphoma (PB-DLBCL) is a rare subtype of non-Hodgkin lymphoma (NHL) with limited data on the clinical features and prognostic factors. Patients and Methods A consecutive cohort of patients with PB-DLBCL was retrospectively analyzed in our hospital from February 1997 through July 2018. The primary endpoint is overall survival (OS) contributing to any cause. Results A total of 76 patients were diagnosed with PB-DLBCL. The median age at diagnosis was 51 years (range: 25-80 years), with female prevalence (98.7%). Forty (52.6%) patients had right-sided breast involvement but no bilateral breast involvement at diagnosis. Overall, disease stages IE and IIE were seen in 55 (72.4%) and 21 (27.6%) patients, respectively. According to the stage-modified International Prognostic Index (IPI), 37 (48.7%) patients were classified in the very good risk group (IPI 0). Of the 72 patients available, the non-germinal center B-cell (non-GCB) subtype of DLBCL was observed in 66 (91.6%) patients. All patients received anthracycline-based chemotherapy, 56 (73.7%) with rituximab, 31 (40.8%) also with additional radiation therapy, and 14 (18.4%) patients received a prophylactic intrathecal injection. Seven (9.2%) patients had refractory disease. With a median follow-up of 6.8 years (range 0.4-25.0 years), 10 (13.2%) patients had a relapse in the central nervous system (CNS) site. The 5-year and 10-year OS of all the patients was 97.2% (95% CI: 99.3-89.5) and 84.8% (95% CI: 70.0-93.5), respectively. The median OS was not reached. The median progression-free survival (PFS) was 10.3 years for patients with PB-DLBCL(Figure 2B). The 5-year PFS of all the patients was 76.3% (95% CI: 64.6-84.6). Univariate analysis revealed several prognostic factors, including stage-modified IPI, breast surgery, refractory disease, and CNS relapse. Multivariate analyses produced two independent prognostic factors for patients with PB-DLBCL, including stage-modified IPI score (2-3 versus 0) (hazard ratio: 19.114, 95% CI 1.841 to 198.451, p=0.013) and CNS relapse (hazard ratio: 5.522, 95% CI 1.059 to 28.788, p=0.043). Conclusion In our cohort, PB-DLBCL clinical features are similar to prior literature reports. Stage-modified IPI score and CNS relapse were associated with overall survival.

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Cancer risk in tuberculosis patients in a high endemic area

Cited by 16 publications

References 36 publications

Risk factors and communities disproportionately affected by cervical cancer in the Russian Federation: A national population-based study

Risk factors and communities disproportionately affected by cervical cancer in the Russian Federation: A national population-based study

Recurrent choriocarcinoma complicated with leprosy during chemotherapy: A case report and literature review

Clinical Characteristics and Prognostic Factors in Primary Breast Diffuse Large B-Cell Lymphoma

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