This study aims to understand the perception of mothers of children with cancer from playing. This was a qualitative study, carried February and April 2016. Six mother were interviewed, who accompanied their children during treatment at a non-governmental organization (NGO) that functions as a support house for children and adolescents with cancer. From the organization of the empirical material, two categories emerged: The mothers' perception on the playful during the oncological treatment and the spirituality adopted by the mothers after the discovery of the diagnosis. The conclusion is that playfulness fulfills a therapeutic function assisting the child in his/her development, providing joy and pleasure. Mothers, on the other hand, find in faith the strength not to lose hope in the continuity in the caring process. Thus, it is evident that mothers seek the best for the child's well-being, in an attempt to minimize the suffering generated by the experienced situation.