Cancer Protective Action of Polysaccharide, Derived from Red MicroalgaPorphyridium Cruentum—A Biological Background

Bioactivity and Applications of Sulphated Polysaccharides from Marine Microalgae

“…However, Geresh and co-workers [64] also found that the non-modified sPS had no significant inhibition at the same concentration as EPS-derivatives. Furthermore, in a recent study, Gardeva et al [65] reported the strong anti-tumour activity exhibited by the polysaccharide of P. cruentum . They found that this sulphated polymer strongly inhibited Graffi myeloid tumour proliferation in vitro and in vivo , that the activity was dose-dependent, and that survival time of hamsters was enhanced in 10–16 days.…”

Cytotoxic and Apoptogenic Potential of Red Microalgal Polysaccharides

“…this study also demonstrated the role of enhanced MnSoD activity coinciding with decreased GR activity in polysaccharide-induced Graffi cell apoptosis. Because of their selective toxicity to cancer cells (this study), their ability to inhibit tumor growth in vivo, and to enhance the immune function of the host (14,15), both PorphPSh and DixPSh represent potential anticancer agents.…”

“…our previous research has shown the potent in vivo antitumor activity of extracellular PShs produced by P. cruentum and D. grisea (14,15). Both PShs decreased the transplantability of Graffi myeloid tumor in hamsters, retarded the tumor growth and reduced the mortality rate.…”

Microalgas: potencial para la producción de compuestos bioactivos nanoencapsulados

“…Así la elaboración de nanocápsulas a partir de polisacáridos Ramírez-Mérida et al : Microalgas: potencial para la producción de compuestos bioactivos nanoencapsulados sulfatados, con demostrado efecto antiviral y antitumoral, provenientes de Porphyridium, Rhodella y la cianobacteria Arthrospira (Gardeva et al, 2009); que recubran moléculas de β-caroteno aisladas de Dunaliella salina con conocido efecto antioxidante y anticancerígeno (Raposo et al, 2013), podrían ser utilizados en pacientes con leucemias de células blancas. En este tipo de pacientes la leucopenia conlleva a numerosas infecciones, así la acción bioactiva antitumoral actuaría sobre leucocitos inhibiendo su proliferación mientras que la acción antiviral ayudaría a combatir infecciones por gérmenes.…”