Cancer prevalence, incidence and mortality rates in Pakistan in 2012

Sarwar, Muhammad Rehan; Saqib, Anum

doi:10.1080/2331205x.2017.1288773

Cited by 56 publications

(44 citation statements)

References 24 publications

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“…Bladder cancer is the ninth most common cancer worldwide. Of all incident cases of different types of cancer in the Pakistani population during the year 2012 (n=148,041), the incidence rate of bladder cancer in the male population was 3,020, which was increased compared with that in the female population (n=946) (23). In muscle-invasive bladder cancers, 58 genetic mutations have been demonstrated to be causative factors for cancer progression in the bladder, and these are associated with low survival rates (24).…”

Section: Caveolin-1 and Dynamin-2 Overexpression Is Associated With Tmentioning

confidence: 99%

Caveolin‑1 and dynamin‑2 overexpression is associated with the progression of bladder cancer

et al. 2019

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Caveolae-mediated endocytosis regulates cell adhesion and growth in an anchorage-dependent manner. Studies of the endocytic function of caveolae have suggested a wide-ranging list of cargoes, including a number of receptors and extracellular proteins, ligands and nutrients from the extracellular matrix. Disruption of the processes of caveolae-mediated endocytosis mediated by signaling proteins is critical to cellular integrity. Caveolin-1 and dynamin-2 are the 2 major proteins associated with endocytotic function. Mechanistically, dynamin-2 has a co-equal role with caveolin-1 in terms of caveolae-derived endosome formation. Recent studies have revealed the pathological outcomes associated with the dysregulation of caveolin-1 and dynamin-2 expression. Increased expression levels of the gene for caveolin, Cav-1, resulting in augmented cellular metastasis and invasion, have been demonstrated in various types of cancer, and overexpression of the gene for dynamin-2, DNM2, has been associated with tumorigenesis in cervical, pancreatic and lung cancer. An increased expression of Cav-1 and DNM2 is known to be associated with the invasive behavior of cancer cells, and with cancer progression. Furthermore, it has been previously demonstrated that, in caveolar assembly and caveolae mediated endocytosis, Cav-1 interacts directly with DNM2 during the processes. Altered expression of the 2 genes is critical for the normal function of the cell. The expression patterns of Cav-1 and DNM2 have been previously examined in bladder cancer cell lines, and were each demonstrated to be overexpressed. In the present study, the expression levels of these 2 genes in bladder cancer samples were quantified. The gene expression levels of Cav-1 and DNM2 were identified to be increased 8.88-and 8.62-fold, respectively, in tumors compared with the normal controls. Furthermore, high-grade tumors exhibited significantly increased expression levels of Cav-1 and DNM2 (both P<0.0001) compared with the low-grade tumors. In addition, compared with normal control samples, the expression of the 2 genes in tumor samples was observed to be highly significant (P<0.0001), with a marked positive correlation identified for the tumors (Pearson's correlation coefficient, r=0.80 for the tumor samples vs. r=0.32 in the normal control samples). Taken together, the results of the present study demonstrated that the overexpression of Cav-1 and DNM2 genes, and a determination of their correlation coefficients, may be a potential risk factor for bladder cancer, in addition to other clinical factors.

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Section: Caveolin-1 and Dynamin-2 Overexpression Is Associated With Tmentioning

confidence: 99%

Caveolin‑1 and dynamin‑2 overexpression is associated with the progression of bladder cancer

et al. 2019

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“…Unfortunately, in low-and middle-income countries especially Pakistan and India, 70 % of deaths occur from cancer [1]. In 2012, breast, lip, oral cavity, lung and liver cancers were increased including Hepatitis and Human Papilloma Virus (HPV) resulting into 25 % of cancer cases in Pakistan [2]. According to WHO, the overall economic impact of cancer on low income countries is increasing.…”

Section: Introductionmentioning

confidence: 99%

Identification of novel anticancer terpenoids from <i>Prosopis juliflora</i> (Sw) DC (Leguminosae) pods

Malik¹,

Ahmed²,

Khan³

2018

Trop. J. Pharm Res

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“…According to GLOBOCAN 2012, 174 new cases of cancers are diagnosed each day and approximately 133 people die daily of the disease. [8] This burden is not expected to decrease due to aging of the population and worsening of the lifestyle factors implicated in cancer initiation and progression. Effective early interventions EDITORIAL J Cancer Allied Spec 2017;3(4):1 have reduced the mortality of the disease, but morbidity is still a major problem before, during and after cancer treatment all around the globe and, especially, in developing countries due to economic problems and lack of focus on multidisciplinary care.…”

Section: Ensuring Quality Of Life Of Cancer Patients Through Optimal mentioning

confidence: 99%

Ensuring Quality of Life of Cancer Patients Through Optimal Oral Health

Chaudhry

Khan

2018

J Cancer Allied Spec

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Cancer prevalence, incidence and mortality rates in Pakistan in 2012

Cited by 56 publications

References 24 publications

Caveolin‑1 and dynamin‑2 overexpression is associated with the progression of bladder cancer

Caveolin‑1 and dynamin‑2 overexpression is associated with the progression of bladder cancer

Identification of novel anticancer terpenoids from <i>Prosopis juliflora</i> (Sw) DC (Leguminosae) pods

Ensuring Quality of Life of Cancer Patients Through Optimal Oral Health

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