Cancer, Phase Angle and Sarcopenia: The Role of Diet in Connection with Lung Cancer Prognosis

Detopoulou, Paraskevi; Voulgaridou, Gavriela; Papadopoulou, Sousana K.

doi:10.1007/s00408-022-00536-z

Cited by 24 publications

(23 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is noted that in the present study, no correlation was documented between PhA and other food groups, such as fish, fruits, legumes, and vegetables. This is in contrast with other studies reporting the protective effect of a Mediterranean diet and omega-3 regarding PhA [6,16,17,26]. This discrepancy may be due to the specific features of the present sample.…”

Section: Discussioncontrasting

confidence: 99%

“…Low values of PhA have been linked with lung cancer prognosis [ 6 ], which implies that the identification of dietary or other factors that could predict or modify PhA may have beneficial prognostic effects. Indeed, several studies report strong correlations between nutrition/nutritional habits and PhA [ 16 , 17 ] Nutritional interventions have been found to increase PhA in colorectal cancer patients [ 18 ], while no data exist regarding lung cancer patients.…”

Section: Discussionmentioning

confidence: 99%

“…Body composition analysis, and especially bioelectrical impedance analysis (BIA), can provide data on classic parameters, such as fat mass, lean body mass, etc., and also on patients’ phase angle (PhA). PhA is a direct measurement of the human body’s cell integrity, has a prognostic value in lung cancer, as has recently been suggested [ 6 ], and may change during cancer therapy [ 7 ]. More particularly, low values of PhA and sarcopenia are connected to lung cancer [ 6 ] and other types of cancer [ 8 ] prognosis through various mechanisms, including inflammation and oxidative stress [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…PhA is a direct measurement of the human body’s cell integrity, has a prognostic value in lung cancer, as has recently been suggested [ 6 ], and may change during cancer therapy [ 7 ]. More particularly, low values of PhA and sarcopenia are connected to lung cancer [ 6 ] and other types of cancer [ 8 ] prognosis through various mechanisms, including inflammation and oxidative stress [ 6 ]. Indeed, inflammatory markers, such as C-reactive protein, interleukin-6, and tumor necrosis factor-a (TNF-a) have been negatively related to PhA measurements [ 9 , 10 , 11 ], while the antioxidant capacity of the plasma has been positively correlated with PhA [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, several dietary interventions have been conducted to combat sarcopenia in patients with lung cancer, with mixed results (protein, oral nutritional supplements with omega-3 fatty acids, multimodal interventions, etc.) [ 6 ]. Moreover, dietary factors, such as omega-3 fatty acids, have recently been related to PhA measurements [ 16 , 17 ] and nutritional interventions have been found to increase PhA in colorectal cancer patients [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Dietary Habits Are Related to Phase Angle in Male Patients with Non-Small-Cell Lung Cancer

et al. 2022

Self Cite

View full text Add to dashboard Cite

Introduction: Lung cancer constitutes the most common cause of cancer death. Phase angle (PhA) has been related to lung cancer prognosis, which implies that the identification of dietary or other factors that could predict or modify PhA may have beneficial effects. Νutritional interventions have been linked with positive changes in PhA in certain types of cancer. Aim: The present study aimed to investigate the relationships between dietary habits/nutrition and PhA in NSCLC patients. Methods: The sample consisted of 82 male patients with non-small-cell lung cancer (NSCLC; stage IV) from the ‘Theageneio’ Cancer Hospital (Thessaloniki, Greece). Several parameters were assessed, such as body mass index (BMI), lean mass, PhA, Mediterranean diet score (MedDietScore), dietary patterns, smoking, resting metabolic rate, resting oxygen consumption (VO2), ventilation rate, and physical activity. Results: According to our results, a dietary pattern rich in potatoes and animal proteins (meat and poultry) was a significant determinant of PhA (B ± SE, p: 0.165 ± 0.08, p = 0.05) in multiple linear regression models after adjusting for age, smoking, lean tissue, and MedDietScore. Conclusion: In conclusion, dietary patterns may affect PhA, suggesting the crucial role of protein in cancer management and the prevention of sarcopenia.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dietary Habits Are Related to Phase Angle in Male Patients with Non-Small-Cell Lung Cancer

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

Longitudinal associations of bioelectrical phase angle and fatigue in breast cancer patients

Schmidt

Chong

Klassen

et al. 2023

Intl Journal of Cancer

View full text Add to dashboard Cite

Cancer‐related fatigue is commonly treated in an undifferentiated manner, because its pathophysiology is still not well understood. Therefore, we investigated if bioelectrical phase angle (PhA), a non‐invasive marker of cell integrity, could help to single out specific fatigue subtypes. In a randomized controlled strength training intervention trial, PhA was measured by bioelectrical impedance analysis in 158 breast cancer patients. Fatigue was assessed with the multidimensional 20‐item Fatigue Assessment Questionnaire. Multiple regression analyses considering changes in PhA and fatigue from baseline to post‐intervention and ANCOVA models investigating the strength training effect on PhA were conducted. Further, explorative mediation and moderation analyses were performed. Decrease (=worsening) in PhA was significantly associated with increase in physical (P = .010) and emotional (P = .019) fatigue. These associations were markedly stronger in patients with normal BMI (interaction P = .059 and .097) and with low pre‐diagnosis exercise level (interaction P = .058 and .19). Among patients with normal BMI strength training was associated with an increase in PhA (ANCOVA P = .059), but not among overweight/obese patients (interaction P = .035). Chemotherapy was a major determinant for low PhA, but PhA did not mediate the effect of chemotherapy on fatigue. In conclusion, PhA has a significant inverse association with physical and emotional fatigue. This association is moderated by BMI and previous exercise. Significant relationships of PhA were also observed with chemotherapy and strength training. Thus, PhA might be a marker that could help in the classification of subtypes of fatigue with different pathophysiology, which may require specifically tailored treatment. Further research on this is warranted.

show abstract

LUNG Year in Review: 2022

Dicpinigaitis

2023

Lung

View full text Add to dashboard Cite

Cancer, Phase Angle and Sarcopenia: The Role of Diet in Connection with Lung Cancer Prognosis

Cited by 24 publications

References 100 publications

Dietary Habits Are Related to Phase Angle in Male Patients with Non-Small-Cell Lung Cancer

Dietary Habits Are Related to Phase Angle in Male Patients with Non-Small-Cell Lung Cancer

Longitudinal associations of bioelectrical phase angle and fatigue in breast cancer patients

LUNG Year in Review: 2022

Contact Info

Product

Resources

About