Dietary Habits Are Related to Phase Angle in Male Patients with Non-Small-Cell Lung Cancer

Detopoulou, Paraskevi; Tsiouda, Theodora; Pilikidou, Maria; Palyvou, Foteini; Mantzorou, Maria; Perzirkianidou, Persefoni; Kyrka, Krystallia; Methenitis, Spyridon; Kondyli, Foivi; Voulgaridou, Gavriela; Matthaios, Dimitris; Oikonomidou, Rena; Romanidou, Maria; Giannakidis, Dimitrios; Papadopoulou, Sousana K.

doi:10.3390/curroncol29110637

Cited by 9 publications

(14 citation statements)

References 45 publications

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“…The causal association of chemotherapy with PhA might be complex. Beyond direct damage to cells by cytostatic drugs, reduced physical activity, altered dietary habits and poor nutritional status as a result of chemotherapy could also play a role with regard to the decreased PhA after chemotherapy 40 . With respect to fatigue, however, our mediation analysis does not suggest a role of PhA in the causal pathway of the chemotherapy effects on fatigue.…”

Section: Discussioncontrasting

confidence: 60%

Longitudinal associations of bioelectrical phase angle and fatigue in breast cancer patients

Schmidt

Chong

Klassen

et al. 2023

Intl Journal of Cancer

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Cancer‐related fatigue is commonly treated in an undifferentiated manner, because its pathophysiology is still not well understood. Therefore, we investigated if bioelectrical phase angle (PhA), a non‐invasive marker of cell integrity, could help to single out specific fatigue subtypes. In a randomized controlled strength training intervention trial, PhA was measured by bioelectrical impedance analysis in 158 breast cancer patients. Fatigue was assessed with the multidimensional 20‐item Fatigue Assessment Questionnaire. Multiple regression analyses considering changes in PhA and fatigue from baseline to post‐intervention and ANCOVA models investigating the strength training effect on PhA were conducted. Further, explorative mediation and moderation analyses were performed. Decrease (=worsening) in PhA was significantly associated with increase in physical (P = .010) and emotional (P = .019) fatigue. These associations were markedly stronger in patients with normal BMI (interaction P = .059 and .097) and with low pre‐diagnosis exercise level (interaction P = .058 and .19). Among patients with normal BMI strength training was associated with an increase in PhA (ANCOVA P = .059), but not among overweight/obese patients (interaction P = .035). Chemotherapy was a major determinant for low PhA, but PhA did not mediate the effect of chemotherapy on fatigue. In conclusion, PhA has a significant inverse association with physical and emotional fatigue. This association is moderated by BMI and previous exercise. Significant relationships of PhA were also observed with chemotherapy and strength training. Thus, PhA might be a marker that could help in the classification of subtypes of fatigue with different pathophysiology, which may require specifically tailored treatment. Further research on this is warranted.

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Section: Discussioncontrasting

confidence: 60%

Longitudinal associations of bioelectrical phase angle and fatigue in breast cancer patients

Schmidt

Chong

Klassen

et al. 2023

Intl Journal of Cancer

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“…This systematic review includes several types of studies: five prospective studies [ 35 – 39 ], three observational studies [ 40 – 42 ], two retrospective studies [ 34 , 43 ] and one cross-sectional study [ 44 ]. Shi et al showed the highest number of patients involved (804).…”

Section: Resultsmentioning

confidence: 99%

“…The remaining selected scientific papers included 30 to 204 patients. Five studies included both males and females, six studies included males only [ 36 , 38 , 40 – 42 , 44 ]. However, in two studies [ 36 , 37 ], we do not know if the percentages of women and men present in the study referred to LC patients or patients with other kind of cancers.…”

Section: Resultsmentioning

confidence: 99%

“…Three other studies investigate PhA in different types of cancer, including LC: they respectively include 8, 244 and 26 patients with LC [ 36 , 37 , 45 ]. All studies showed patients with confirmed cancer diagnosis: five studies evaluated NSCLC patients with stage III and IV [ 34 , 38 , 40 – 42 ]. Shi et al included adenocarcinoma, squamous cell carcinoma, SCLC and other type of LC patients in different stage of disease (from I to IV) [ 39 ].…”

Section: Resultsmentioning

confidence: 99%

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Bioelectrical impedance analysis—derived phase angle (PhA) in lung cancer patients: a systematic review

Prete,

Ballarin,

Porciello

et al. 2024

BMC Cancer

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Background Lung cancer is the second most diagnosed cancer in the world. Up to 84% of diagnosed patients have malnutrition, which can negatively affect quality of life and survival and may worsen with neoadjuvant treatment. Bioelectrical Impedance Analysis-Derived Phase Angle (PhA) in these patients could be a valid tool to assess the nutritional status in order to improve their condition. Methods This review provides an update on PhA assessment in lung cancer patients over the past twenty years. We searched PubMed, Embase, Scopus, Web of Science, and Cochrane, for articles regarding the PhA obtained from Bioelectrical Impedance Analysis in lung cancer patients. The authors independently performed a literature search: sample size, patient population, study type, study dates, survival and interventions were evaluated. The final review included 11 studies from different countries. Results Eight studies only considered patients with lung cancer, while three studies considered patients with different kind of cancer, including lung. Correlation data between PhA and age are conflicting. In patients undergoing clinical treatment and patients undergoing surgical treatment lower PhA was observed. A lower PhA is associated with a shorter survival. In three studies emerged a relationship between Karnofski Performance Status and Handgrip Strenght with PhA. From one study, univariate logistic regression analysis showed that higher PhA values represent a protective factor for sarcopenia. Conclusion Our research underlined interesting, but not conclusive, results on this topic; however more researches are needed to understand the clinical meaning of PhA.

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“…Moreover, it is possible that the total diet and/or dietary protein may be important in addressing this issue, since sarcopenia often co-exists with osteoporosis (osteosarcopenia) [ 70 ]. In this case, animal protein may be a key factor for modifying body composition and sarcopenia, such as in the case of cancer, which is also related to sarcopenia [ 71 , 72 ]. In addition, inflammatory indices, such as platelet activating factor, are related to OF [ 73 ], and an antioxidant-rich diet and/or fatty acid profile may lessen its deleterious actions [ 74 , 75 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and Calcium in Osteoporosis, and the Role of Bone Turnover Markers: A Narrative Review of Recent Data from RCTs

et al. 2023

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Osteoporosis is a common disease, defined primarily by a low measured bone density, which is associated with an increased risk of fragility fractures. Low calcium intake and vitamin D deficiency seem to be positively correlated with the prevalence of osteoporosis. Although they are not suitable for the diagnosis of osteoporosis, the biochemical markers of bone turnover can be measured in serum and/or urine, enabling the assessment of the dynamic bone activity and the short-term effectiveness of the osteoporosis treatment. Calcium and vitamin D are essential for maintaining bone health. The aim of this narrative review is to summarize the effects of vitamin D and calcium supplementation separately and in combination, on bone density and circulating serum and blood plasma vitamin D, calcium, parathyroid hormone levels, markers of bone metabolism concentrations, and clinical outcomes, such as falls and osteoporotic fractures. We searched the PubMed online database to find clinical trials from the last five years (2016–April 2022). A total of 26 randomized clinical trials (RCTs) were included in this review. The present reviewed evidence suggests that vitamin D alone or in combination with calcium increases circulating 25(OH)D. Calcium with concomitant vitamin D supplementation, but not vitamin D alone, leads to an increase in BMD. In addition, most studies did not detect significant changes in circulating levels of plasma bone metabolism markers, nor in the incidence of falls. Instead, there was a decrease in blood serum PTH levels in the groups receiving vitamin D and/or Ca supplementation. The plasma vitamin D levels at the beginning of the intervention, and the dosing regimen followed, may play a role in the observed parameters. However, further study is needed to determine an appropriate dosing regimen for the treatment of osteoporosis and the role of bone metabolism markers.

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Dietary Habits Are Related to Phase Angle in Male Patients with Non-Small-Cell Lung Cancer

Cited by 9 publications

References 45 publications

Longitudinal associations of bioelectrical phase angle and fatigue in breast cancer patients

Longitudinal associations of bioelectrical phase angle and fatigue in breast cancer patients

Bioelectrical impedance analysis—derived phase angle (PhA) in lung cancer patients: a systematic review

Vitamin D and Calcium in Osteoporosis, and the Role of Bone Turnover Markers: A Narrative Review of Recent Data from RCTs

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