Cancer patterns in Karachi (all districts), Pakistan: First results (2010–2015) from a Pathology based cancer registry of the largest government-run diagnostic and reference center of Karachi

Qureshi, Muhammad Asif; Mirza, Talat; Khan, Saeed; Sikandar, Bushra; Zahid, Maria; Aftab, Marium; Mohsin, Sehrish; Sharafat, Shaheen; Avesi, Lubna; Hassan, Sidra

doi:10.1016/j.canep.2016.08.011

Cited by 31 publications

(41 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Variations in the cancer data obtained from various studies conducted in different parts of the country are shown in Table 1 and appear to be quite marked and significant. The data for analyzing the prevalence and heterogeneity of specific types of cancer was obtained from 13 studies of which 5 were from Karachi [ 1 , 6 , 7 , 15 ], 4 from Lahore [ 4 , 5 , 14 ], and 1 each from the Hazara Division in Khyber Pakhtunkhwa, Multan Division in Punjab, Larkana Division in Sindh, and Hyderabad Division in Sindh, respectively [ 2 , 3 , 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cancer prevalence in Pakistan: meta-analysis of various published studies to determine variation in cancer figures resulting from marked population heterogeneity in different parts of the country

et al. 2018

View full text Add to dashboard Cite

BackgroundPakistan’s population is ethnically diverse with distinct ethnic groups inhabiting various parts of the country. Cancer statistics obtained from specific regions populated by distinct ethnic groups may vary considerably. There is no national cancer registry. To determine whether there are indeed significant statistical differences in cancer incidence and prevalence, data was recorded from different parts of Pakistan based on the ethnic composition of the population in those parts.MethodsTen papers (original articles) on cancer incidence and prevalence in Pakistan published in the last two decades were selected from PubMed and Google Scholar. Meta-analysis of findings of these studies was performed using Meta-analysis of Observational Studies in Epidemiology (MOOSE) checklist. χ2-based I2 test was used for evaluating heterogeneity and Forest plots were generated for calculating unadjusted prevalence estimates. Oral, gastric, prostate, breast, and colorectal cancers were selected for meta-analysis. I2 values of 75% or greater indicated high heterogeneity.ResultsAll five types of cancer selected for meta-analysis (performed on studies carrying similar statistical weights) showed extremely high heterogeneity with I2 values of 99.7% for oral cancer, 98.6% for prostate cancer, 98.3% for gastric cancer, 99.8% for breast cancer, and 85.4% for colorectal cancer. p values for all cancers were highly statistically significant.ConclusionsOur findings show that the prevalence rates of different cancer types demonstrate marked variation in different studies depending on the place of origin of the study and dominant ethnic group in that region, and these variations are highly statistically significant. A national cancer registry needs to be established as soon as possible.

show abstract

Section: Discussionmentioning

confidence: 99%

“…It is not known what protective factors in Pakistani males contribute to relatively low incidence of prostate cancer in Pakistan. [ 1 , 2 , 4 – 6 , 8 , 15 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Cancer prevalence in Pakistan: meta-analysis of various published studies to determine variation in cancer figures resulting from marked population heterogeneity in different parts of the country

et al. 2018

View full text Add to dashboard Cite

show abstract

“…With this context, we established the Dow Cancer Registry at the largest public-sector diagnostic & reference laboratory of Karachi – the Dow Labs. 8 Our cancer registry registers patients from all over the city via the Dow labs which has >25 collection points distributed throughout the city. Cancer data presented herein are therefore large-scale high quality regional data representative of all districts of Karachi (~17.4 million).…”

Section: Introductionmentioning

confidence: 99%

Common Cancers in Karachi, Pakistan: 2010-2019 Cancer Data from the Dow Cancer Registry

et al. 2020

Self Cite

View full text Add to dashboard Cite

Objectives: To present 2010-2019 cancer data from the Dow Cancer Registry representing all districts of Karachi (~17.4 million). Methods: The study was conducted at the Dow University of Health Sciences. After ethical approval, the Dow Cancer Registry was established at the largest government-run diagnostic and reference center of Karachi (Dow Labs). All cancers registered during 2010-2019 were analyzed. Patients >18years of age were labeled as adults while those with ages ≤18years were classified as children/young adults. Results: During 2010-2019, a total of 22,858 cancers were registered. Of these, 9,112(39.9%) cancers were diagnosed in males while 13,746(60.1%) in females. Incidence rates for all cancers (all ages) were 108/1,00,000 for males and 188.6/1,00,000 for females. In adult males, cancer of lip and oral cavity was the most frequently diagnosed cancer (33.6%), followed by non-melanoma –skin-cancer (NMSC) (7.2%), oesophagus (6.8%), colorectum (6.7%) and stomach (4.9%). In adult females, breast cancer was the most frequently recorded malignancy (53.2%), followed by cancers of lip and oral cavity (10.4%), oesophagus (5.3%), colorectum (3.3%) and NMSC (3%). In children, most common malignancy was that of brain and nervous system (15.3%), followed by Hodgkin’s lymphoma (14.2%), colorectum (8.1%), endocrine-&-related organs (8%) and non-Hodgkin’s lymphoma (7.8%) Conclusion: Cancers of lip and oral cavity and breast cancer were the most common malignancies in males and females respectively. In paediatric group, cancers of brain and nervous system were most common. Alarmingly, Karachi males have highest ASR of cancers of lip and oral cavity compared to any other city of Pakistan. doi: https://doi.org/10.12669/pjms.36.7.3056 How to cite this:Qureshi MA, Khan S, Sharafat S, Quraishy MS. Common Cancers in Karachi, Pakistan: 2010-2019 Cancer Data from the Dow Cancer Registry. Pak J Med Sci. 2020;36(7):---------. doi: https://doi.org/10.12669/pjms.36.7.3056 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

show abstract

“…Pakistan is burdened with one of the highest incidence rates of OC in the world with strong male preponderance ( 10 ). Several risk factors have been established that contribute to observed prevalence trends in our population, including specific habits such as tobacco, alcohol, paan (betel quid), smokeless tobacco (including chewing tobacco and snuff), and betel nut consumption rendering population bearing lower socioeconomic status more susceptible to OC.…”

Section: Introductionmentioning

confidence: 99%

Risk factors of Oral cancer- A hospital based case control study

et al. 2018

View full text Add to dashboard Cite

BackgroundOral cancer is a highly prevalent malignancy in Pakistan. Among various risk factors associated with this neoplasm, habits such as smoked and smokeless tobacco usage, betel quid, and betel nut consumption are the major culprits in our society. In the present study, we aimed to ascertain prevalent risk factors for OC in our population and to compare our findings with healthy controls to establish their significance.Material and MethodsA hospital-based case control study was conducted at Dow University of Health Sciences, Pakistan from January 2015 – September 2016. Information pertaining to unhealthy oral habits was obtained from 62 oral cancer patients (cases) and 62 healthy controls on specifically designed proforma by the principal investigator.ResultsSmokeless tobacco is strong, independent risk factor for oral cancer development in our study population. Buccal mucosa is the predominantly affected site (71%) which corresponds with high smokeless tobacco use. All studied habits increase risk of oral cancer as demonstrated by high odds ratio.ConclusionsDespite advancement in our knowledge and understanding of carcinogenic potential of these hazardous substances not enough efforts have been put forth to effectively control their widespread sale and consumption, particularly by the youth in our society. Key words:Betel Quid, Gutka, Oral Cancer Risk, Smokeless Tobacco.

show abstract

Cancer patterns in Karachi (all districts), Pakistan: First results (2010–2015) from a Pathology based cancer registry of the largest government-run diagnostic and reference center of Karachi

Cited by 31 publications

References 13 publications

Cancer prevalence in Pakistan: meta-analysis of various published studies to determine variation in cancer figures resulting from marked population heterogeneity in different parts of the country

Cancer prevalence in Pakistan: meta-analysis of various published studies to determine variation in cancer figures resulting from marked population heterogeneity in different parts of the country

Common Cancers in Karachi, Pakistan: 2010-2019 Cancer Data from the Dow Cancer Registry

Risk factors of Oral cancer- A hospital based case control study

Contact Info

Product

Resources

About