Cancer patterns and trends in Central and South America

Sierra, Mónica S.; Soerjomataram, Isabelle; Antoni, Sébastien; Laversanne, Mathieu; Piñeros, Marion; Vries, Esther de; Forman, David

doi:10.1016/j.canep.2016.07.013

Cited by 86 publications

(101 citation statements)

References 82 publications

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“…In the past 10 years, the development and increased use of NGS technologies has allowed a comprehensive characterization of the genomic landscape of tumors [3] . Countries in LA have started to develop the foundations for achieving the integration of cancer genomics into the clinical scenario.…”

Section: Discussionmentioning

confidence: 99%

“…These disparities are of great concern, especially when looking at the increasing cancer burden in the region for breast, colorectal, and lung cancer [31] . These particular cancer types currently benefit from genomic testing and analysis in different clinical scenarios: cancer prevention (the identification of high-risk BRCA1 , BCRA2 , MLH1 , MSH2 , MSH6 , PMS2 , or EPCAM in carriers to control for hereditary breast and colon cancer) [3] , tumor genomic profiling for diagnosis and prognosis (gene expression profile in breast cancer; DNA methylation and microsatellite instability in colorectal cancer) [11] , and personalized treatment (molecule-guided targeted therapy for lung, breast, and colorectal cancer) [32] . The efforts to increase the necessary capacities and resources for the implementation of cancer genomics in LA will only be successful if guided by cancer control programs and public health policies.…”

Section: Discussionmentioning

confidence: 99%

“…Breast cancer is the leading cause of cancer incidence and mortality among women in the majority of countries [2] . Infection-related cancers such as cervical and stomach cancers remain the leading incident types in countries with a medium Human Development Index (HDI) [3] . In contrast, westernization changes in diet and physical activity, as well as increased obesity, are the main risk factors for colorectal cancer, the third most prevalent cancer type in LA [3] .…”

Section: Introductionmentioning

confidence: 99%

“…Infection-related cancers such as cervical and stomach cancers remain the leading incident types in countries with a medium Human Development Index (HDI) [3] . In contrast, westernization changes in diet and physical activity, as well as increased obesity, are the main risk factors for colorectal cancer, the third most prevalent cancer type in LA [3] . Overall, cancer mortality rates in LA are high, mainly due to deficiencies in prevention, early detection, and disease management [4,5] .…”

Section: Introductionmentioning

confidence: 99%

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Cancer Genomic Resources and Present Needs in the Latin American Region

Torres

Oliver

Frecha

et al. 2017

Public Health Genomics

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In Latin America (LA), cancer is the second leading cause of death, and little is known about the capacities and needs for the development of research in the field of cancer genomics. In order to evaluate the current capacity for and development of cancer genomics in LA, we collected the available information on genomics, including the number of next-generation sequencing (NGS) platforms, the number of cancer research institutions and research groups, publications in the last 10 years, educational programs, and related national cancer control policies. Currently, there are 221 NGS platforms and 118 research groups in LA developing cancer genomics projects. A total of 272 articles in the field of cancer genetics/genomics were published by authors affiliated to Latin American institutions. Educational programs in genomics are scarce, almost exclusive of graduate programs, and only few are concerning cancer. Only 14 countries have national cancer control plans, but all of them consider secondary prevention strategies for early diagnosis, opportune treatment, and decreasing mortality, where genomic analyses could be implemented. Despite recent advances in introducing knowledge about cancer genomics and its application to LA, the region lacks development of integrated genomic research projects, improved use of NGS platforms, implementation of associated educational programs, and health policies that could have an impact on cancer care.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cancer Genomic Resources and Present Needs in the Latin American Region

Torres

Oliver

Frecha

et al. 2017

Public Health Genomics

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“…Algunos informes indican que en la década pasada esa incidencia fue de 35.6, y que pasó de 14.2 en 2001 a 25.2 en 2011, con afección principalmente entre mujeres mayores de 55 años, así como que la mortalidad en el país es de 15 por cada 100 000 mujeres mayores de 20 años. [4][5][6][7] En una escala mundial, el cáncer de mama es la segunda neoplasia con mayor índice de metástasis al SNC (10-16%). [8][9] Debido a la detección temprana y al acceso a un tratamiento óptimo, la supervivencia global de esta enfermedad se ha elevado por distintos factores; sin embargo, la frecuencia de metástasis al SNC también se han incrementado, lo que agrava el pronóstico.…”

Section: Salud Pública De México / Vol 60 No 2 Marzo-abril De 2018unclassified

Factores pronósticos en pacientes con cáncer de mama y metástasis cerebral como primer sitio de recurrencia

et al. 2018

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Objetivo. Evaluar los factores pronósticos (características clínico-patológicas y tratamientos) en las pacientes con cáncer de mama y metástasis al sistema nervioso central (SNC) como primer sitio de afección. Material y métodos. Cohorte retrospectiva, formada por 125 pacientes con cáncer de mama atendidas en el Instituto Nacional de Cancerología durante 2007-2015, quienes presentaron afección en el SNC como primer sitio de metástasis. A través del método Kaplan-Meier y tablas de vida se estimó la supervivencia global. El modelo de riesgos proporcionales de Cox fue utilizado para determinar los factores pronósticos. Resultados. La mediana de supervivencia global fue de 14.2 meses (IC95% 11.8-26.9). Pacientes clasificadas por inmunohistoquímica como triple negativo (TN) presentaron tiempos de supervivencia más cortos (p<0.004) y con dos veces más riesgo de fallecer, en comparación con los otros inmunofenotipos (HR= 2.77; IC95% 1.10-6.99); asimismo, se identificó que un grado intermedio en la escala Scarff-Bloom-Richardson incrementa el riesgo de morir en pacientes con metástasis (HR=2.76; IC95% 1.17- 6.51). Conclusiones. La metástasis al SNC continúa siendo un factor de mal pronóstico que reduce la supervivencia y afecta la calidad de vida. Se recomienda vigilar puntualmente la presencia de manifestaciones clínicas neurológicas durante el seguimiento, para una rápida intervención. Las pacientes TN tienen peor pronóstico, y las HER2+ (es decir, con resultado positivo para el receptor 2 del factor de crecimiento humano epidérmico), mejor control a mediano plazo.

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Colorectal Cancer Screening Programs in Latin America

Montalvan-Sanchez,

Norwood,

Dougherty

et al. 2024

JAMA Netw Open

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ImportanceColorectal cancer (CRC) is a leading cause of cancer-related mortality globally, with increasing incidence and mortality in Latin America. CRC screening programs can reduce disease burden, but information on screening programs in Latin America is limited.ObjectiveTo describe characteristics (eg, type of program, uptake, neoplastic yield) of CRC screening programs in Latin America.Data SourcesPubMed, Ovid MEDLINE, EMBASE, Cochrane, PsycINFO, Web of Science Core Collection, LILACS, and SciELO were searched from inception to February 2023. Relevant references from bibliographies, conference proceedings, and gray literature were considered. The search strategy included English, Spanish, and Portuguese terms.Study SelectionIncluded were studies of CRC screening programs in Latin America using fecal immunochemical test (FIT) or colonoscopy as the primary screening method. Four reviewers independently assessed study eligibility based on titles, with review of abstracts and full texts as needed.Data Extraction and SynthesisGuidelines from Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were followed for data abstraction and quality assessment. Descriptive information was extracted, and data were pooled using a random-effects model.Main outcomes and MeasuresProgram performance indicators included rates of participation and FIT positivity, adenoma detection rate (ADR), advanced adenoma detection rate (AADR), CRC detection rate, and colonoscopy quality indicators.ResultsThere were 17 studies included from upper middle-income and high-income countries in Latin America with a total of 123 929 participants. Thirteen studies used FIT as the initial screening method, whereas 4 used screening colonoscopy. The participation rate in FIT-based programs was 85.8% (95% CI, 78.5%-91.4%). FIT positivity rates were 15.2% (95% CI, 9.6%-21.8%) for the 50-ng/mL threshold and 9.7% (95% CI, 6.8%-13.0%) for the 100-ng/mL threshold. For FIT-based studies, the pooled ADR was 39.0% (95% CI, 29.3%-49.2%) and CRC detection rate was 4.9% (95% CI, 2.6%-7.9%); for screening colonoscopy–based studies, the pooled ADR was 19.9% (95% CI, 15.5%-24.8%) and CRC detection rate was 0.4% (95% CI, 0.1%-0.8%).Conclusions and RelevanceThis systematic review and meta-analysis suggests that CRC screening in upper middle-income countries in Latin America is feasible, detecting rates of neoplasia comparable with those of high-income regions. Population-based screening programs should be developed or enhanced in these settings. There is a knowledge gap regarding feasibility and yield of screening programs in lower middle-income countries.

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Cancer patterns and trends in Central and South America

Cited by 86 publications

References 82 publications

Cancer Genomic Resources and Present Needs in the Latin American Region

Cancer Genomic Resources and Present Needs in the Latin American Region

Factores pronósticos en pacientes con cáncer de mama y metástasis cerebral como primer sitio de recurrencia

Colorectal Cancer Screening Programs in Latin America

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