Cancer of the tongue in patients less than forty

Pitman, Karen T.; Johnson, Jonas T.; Wagner, Robin L.; Myers, Eugene N.

doi:10.1002/(sici)1097-0347(200005)22:3<297::aid-hed14>3.0.co;2-3

Cited by 116 publications

(97 citation statements)

References 34 publications

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“…Recently, there has been an increase in the number of young adults who develop oral cancer especially cancer of the tongue, without any apparent risk factors such as tobacco use or immunosuppressant (Llewellyn et al, 2001;Pitman et al, 2000).…”

Section: Demographic Features Of People With Oral Cancermentioning

confidence: 99%

Oral Cancer Knowledge, Attitudes, and Practices among Dentists in Khartoum State, Sudan

Ahmed

Naidoo

2017

J Canc Educ

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The incidence of oral cancer is rising in the Sudan. Detecting oral cancer at an early stage is the most effective means of improving survival and reducing morbidity from disease. Aim:The aim of the present study was to determine the knowledge, attitude and practice of dentists related to oral cancer prevention and early detection in public dental clinics in Khartoum State, Sudan. Materials and Methods:A cross-sectional survey using an administered structured questionnaire was carried out. The questionnaire consisted of 28 questions that included the key areas of oral cancer prevention and early detection. A sample of 130 dental practitioners was requested to participate in the study. Results:The response rate was 86.92%. The majority were female (68.1%) between the ages of 20 -40 years old. The majority were aware of the major risk factors and the most common presentations of oral cancer. About two thirds (63.7%) perceived that their knowledge on oral cancer was current. However, almost a third (35.4.6%) reported that they had sufficient knowledge concerning oral cancer prevention. More than half (54 percent) reported that they do not carry out any special examination to detect oral cancer in asymptomatic patients. Two thirds (66.3%) believed that their undergraduate training in the diagnosis of oral cancer was inadequate. The vast majority (95.6%) were interested in further oral cancer continuing education and 88.5% that development of referral guidelines can improve the quality of referrals to specialists. Conclusions:The findings of the present study indicate that there is a need for further training in the early detection and prevention of oral cancer, as well as an increased emphasis on oral cancer diagnosis and prevention in the dental training curriculum.3 Declaration I, the undersigned, hereby declare that the work contained in this dissertation is my original work and that it has not been previously in its entirety or in part submitted at any university for a degree.………………………………… …………………………

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Section: Demographic Features Of People With Oral Cancermentioning

confidence: 99%

Oral Cancer Knowledge, Attitudes, and Practices among Dentists in Khartoum State, Sudan

Ahmed

Naidoo

2017

J Canc Educ

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“…Other aspects of the disease also differ between young and old patients, for example the male to female ratio is lower in the younger group (11). SCCHN has been described in some reports as being more aggressive in younger patients (12,13), whereas other reports have not found any difference, or even seen better survival in young patients (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

Gene expression profiling of archival tongue squamous cell carcinomas provides sub-classification based on DNA repair genes

Rentoft

Laurell²,

Coates³

et al. 2009

Int J Oncol

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Abstract.A subgroup of patients with squamous cell carcinoma of the head and neck (SCCHN) comprise young persons under the age of 40, who have not been heavily exposed to the classical risk factors, smoking and alcohol. The number of SCCHN in young adults, particularly tongue tumours, is increasing in several parts of the world. Here we employed a novel gene expression array methodology specifically developed for analysis of degraded RNA and investigated the expression of 502 cancer-related genes in archival paraffin-embedded SCCHN of the tongue from young (≤40) and elderly patients (≥50). Genes detected as de-regulated in tumours compared to non-malignant controls were in concordance with results from earlier studies of fresh frozen material. No genes were detected as significantly differentially expressed between young and old patients suggesting that the overall pathobiology of SCCHN is similar in young and old. Unsupervised clustering divided tumours into three groups, irrespective of age, where several differentially expressed DNA repair genes were a prominent separation factor. High levels of DNA repair genes associated with impaired therapeutic response to radiation, suggesting that DNA repair genes play a role in clinical outcome after radiotherapy.

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“…It seems that biological behavior and etiology of OSCC in young patients are unlike older age groups and some studies suggest that oral cancer in young patients is more aggressive (6). Recent studies revealed that there is no difference between clinical course and survival rate (2,(7)(8)(9). Iran is a large country located in the Middle East and Khorasan is one of the largest provinces in Iran covering 7.8% of the total area of this country.…”

Section: Introductionmentioning

confidence: 99%

Clinical and histopathological analysis of oral Squamous cell carcinoma of young patients in Mashhad, Iran: A retrospective study and review of literature

Falaki¹,

Dalirsani²,

Pakfetrat³

et al. 2011

Med Oral

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Objectives: Oral Squamous cell carcinoma (OSCC) is primarily a disease that mainly occurs in males in their sixth and seventh decades of life and is rare in young adults. Study Design: In this retrospective study, records of patients under the age of 40, with the diagnosis of OSCC in the Oral Medicine Department of Mashhad Dental Faculty during the past 13 years were analyzed. Their socioeconomic data, demographic, clinical and histopathological characteristics, risk factors, familial history were assessed and applicable studies and case reports in the literatures were reviewed. PCR (Polymerase chain reaction) analysis was also done for detection of human papilloma virus (HPV). Results: From 158 cases of OSCC diagnosed in our centre, 21 patients were younger than 40 years. Most of them were young men (12 cases). There was no significant risk factor in this group. The most common site of involvement was the tongue. The most common clinical presentation was exophytic lesion with ulcer. No HPV DNA was detected in these patients. Conclusion: Characteristics of OSCC in young patients are different from older age group. Major risk factors (smoking and alcohol consumption and HPV) were not etiologic factors for OSCC in young patients in our province.

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Cancer of the tongue in patients less than forty

Cited by 116 publications

References 34 publications

Oral Cancer Knowledge, Attitudes, and Practices among Dentists in Khartoum State, Sudan

Oral Cancer Knowledge, Attitudes, and Practices among Dentists in Khartoum State, Sudan

Gene expression profiling of archival tongue squamous cell carcinomas provides sub-classification based on DNA repair genes

Clinical and histopathological analysis of oral Squamous cell carcinoma of young patients in Mashhad, Iran: A retrospective study and review of literature

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