Cancer of the buccal mucosa: Are margins and T-stage accurate predictors of local control?

Sieczka, Elizabeth M.; Datta, Rajiv; Singh, Anand; Loree, Thom R.; Rigual, Néstor R.; Orner, James B.; Hicks, Wesley L.

doi:10.1053/ajot.2001.28067

Cited by 107 publications

(82 citation statements)

References 12 publications

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“…Similar with our findings, the incidence of lymph node metastasis of buccal carcinoma ranged as 0%-80% for T3 tumors and 50%-63% for T4a tumors in literature (2,3,8).…”

Section: Discussionsupporting

confidence: 91%

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Advanced Stage Buccal Carcinoma: Effect of Local Extension on Prognosis

Cömert¹,

Tuncel²,

Turan³

et al. 2018

Cyprus J Med Sci

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BACKGROUND/AIMSThe aim of this study was to evaluate the effects of alveolar mucosa, bone, cheek skin, and lip invasion of buccal carcinoma on locoregional recurrence and survival rates. MATERIALS and METHODSThe study included 36 patients with T3-T4a buccal carcinoma. Both T3 and T4a tumors were divided into two subgroups: T3 tumors limited to buccal mucosa, T3 tumors with the involvement of alveolar mucosa, T4a tumors with bone invasion, and T4a tumors with skin and/or lip invasion. RESULTSIn T3-T4a tumors, the rates of tumors limited to the buccal mucosa, tumors involving alveolar mucosa, bone of either the maxilla or mandible, and skin and/or lips were 25%, 22.2%, 33.3%, and 19.4%, respectively. The 3-year disease-free survival rate of patients with T3 and T4a tumors was 70.6% and 52.6%, respectively. The 5-year disease-free survival rate of patients with T3 and T4a tumors was 58.8% and 42.1%, respectively. Regarding the 3-and 5-year survival rates, no statistically significant difference was observed between T3 and T4a tumors and between their subgroups. CONCLUSIONDespite the lack of statistical significance, there seemed to be a trend toward worse survival among the patients with bone invasion.

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“…Similar with our findings, the incidence of lymph node metastasis of buccal carcinoma ranged as 0%-80% for T3 tumors and 50%-63% for T4a tumors in literature (2,3,8).…”

Section: Discussionsupporting

confidence: 91%

“…Therapeutic neck dissection has been performed in early stage tumors with neck metastasis and in all advanced stage tumors. (2,4,5).…”

Section: Introductionmentioning

confidence: 99%

Advanced Stage Buccal Carcinoma: Effect of Local Extension on Prognosis

Cömert¹,

Tuncel²,

Turan³

et al. 2018

Cyprus J Med Sci

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“…Pop et al 22 showed a local recurrence rate of 45% for 40 patients with buccal cancer and 70% for 10 patients with stage IV disease. Sieczka et al 23 revealed a 56% local recurrence rate for 27 patients with buccal cancer who underwent surgery alone. A report from Taiwan on 57 patients treated with surgery plus postoperative radiotherapy resulted in a 39% locoregional recurrence rate.…”

Section: Discussionmentioning

confidence: 99%

“…This falls within the 29% to 100% incidence reported in the literature. 15,21,23 A previous report from Taiwan on 57 patients concluded that postoperative radiotherapy was effective in decreasing locoregional failure in patients with close surgical margins, tumor thickness greater than 10 mm, high-grade tumors, and positive node and bone invasion. 13 Of the patients in this study, the S group and S + RT group had similar treatment outcomes in both early and advanced stages despite the fact that 20 of the 58 patients who had S + RT had positive or close surgical margins, whereas no patient in the S group had positive margins.…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma of the buccal mucosa: An aggressive cancer requiring multimodality treatment

et al. 2006

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Background. In our clinical practice, we have observed a high incidence of locoregional failure in squamous cell carcinoma (SCC) of the buccal mucosa. We analyze our treatment results of this cancer and compare these results with those in the literature. We intend to define the pattern and incidence of failure of buccal cancer and provide information for the design of a better multimodality treatment.Methods. During the period from 1983 through 2003, 121 previously untreated patients with M0 stage SCC of the buccal mucosa were treated with a curative intent at our hospital. Twenty-seven patients received surgery alone, 36 had radiotherapy alone, and 58 underwent surgery plus postoperative radiotherapy.Results. The 5-year locoregional control, overall survival, and cause-specific survival rates for all patients were 36.3%, 34.3%, and 36.9%, respectively. The locoregional recurrence rate was 57% for all patients, with 80% occurring in the primary site alone. Patients with T1 -2N0 disease who received surgery alone still had a high local recurrence incidence of 41%. For patients with locally advanced disease, surgery plus postoperative radiotherapy achieved better overall survival and locoregional control rates than surgery alone or radiotherapy alone. T classification was the only prognostic factor affecting locoregional control and survival in the surgery alone group, whereas N classification and skin invasion predicted a poorer survival for the surgery plus postoperative radiotherapy group.Conclusions. SCC of the buccal mucosa is an aggressive cancer with a high locoregional failure rate even in patients with T1 -2N0 disease. Possible reasons include inadequate treatment and an intrinsically aggressive nature. Postoperative radiotherapy has resulted in a better locoregional control rate for patients with T3 -4 or N+ disease and should also be considered for patients with T1 -2N0 disease for whom adjuvant therapy after radical surgery currently is not recommended by most guidelines. A 2005 Wiley Periodicals, Inc. Head Neck 28: 150 -157, 2006

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“…While in the population of North America, the 7 th and 8 th decade is the most susceptible period. 3,4 Statistical data for [2003][2004][2005][2006][2007] in USA demonstrates that the median age at diagnosis for cancer of the upper aero-digestive tract was 62 years while a morphological study of OSCC carried out in Pakistan by Ayaz and his co-workers reported a mean age of 53 years. 5,6 This ethnic variation may be due to difference in social and cultural practices, and the effect of different dietary and genetic factors.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and pathological trends in oral squamous cell carcinoma in a local tertiary care hospital

Gul

Asif

Ghaffar

et al. 2017

Int J Community Med Public Health

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Background: Cancer archives perform a dynamic role in observing the prevalence of these cancers. The present study was carried out to study the epidemiological and pathological trends of oral squamous cell carcinoma (OSCC) in a local tertiary care hospital. Methods: Tissue samples were taken from the adult patients of both genders undergoing surgery for OSCC after an informed consent following the inclusion and exclusion criteria. Socio-demographic information was obtained along with relevant clinical, laboratory findings. Tissue samples were stained with H & E stains and were graded according to Anneroth’s system of histological grading. Data were analysed using SPSS 20.0 and a p value ≤0.05 was taken as significant. Results: The most common site for OSCC was tongue and the most common histological subtype was conventional squamous cell carcinoma, while well differentiated tumours form the largest number in the current study. Conclusions: OSCC is a growing malignancy in Pakistan with significant morbidity and mortality and the findings of the present study will be a valuable addition in the local cancer archives.

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Cancer of the buccal mucosa: Are margins and T-stage accurate predictors of local control?

Cited by 107 publications

References 12 publications

Advanced Stage Buccal Carcinoma: Effect of Local Extension on Prognosis

Advanced Stage Buccal Carcinoma: Effect of Local Extension on Prognosis

Squamous cell carcinoma of the buccal mucosa: An aggressive cancer requiring multimodality treatment

Epidemiology and pathological trends in oral squamous cell carcinoma in a local tertiary care hospital

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