1948
DOI: 10.1016/s0022-5347(17)69346-7
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Cancer of the Breast in the Male, Secondary to Estrogenic Administration: Report of a Case

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Cited by 49 publications
(7 citation statements)
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“…They claimed that this represents a vastly increased incidence when compared with non Klinefelter males. Gynecomastia and breast cancer have also followed administration of oestrogens for prostatic cancer (Abramson and Warshawsky, 1948;Howard and Grosjean, 1948;O'Grady and McDivitt, 1969) but, considering the extensive use of oestrogens for this condition, this complication rate must be regarded as almost negligible. Microscopic gynecomastia occasionally shows florid and sometimes worrisome epithelial hyperplasia but only occasionally has definite malignant change been documented.…”
Section: Discussionmentioning
confidence: 99%
“…They claimed that this represents a vastly increased incidence when compared with non Klinefelter males. Gynecomastia and breast cancer have also followed administration of oestrogens for prostatic cancer (Abramson and Warshawsky, 1948;Howard and Grosjean, 1948;O'Grady and McDivitt, 1969) but, considering the extensive use of oestrogens for this condition, this complication rate must be regarded as almost negligible. Microscopic gynecomastia occasionally shows florid and sometimes worrisome epithelial hyperplasia but only occasionally has definite malignant change been documented.…”
Section: Discussionmentioning
confidence: 99%
“…The breast tumor (adenocarcinoma) was unilateral, and opinion differed among several pathologists as to whether it was primary or metastatic. In 1948 Abramson and Warshawsky (4) cited a case of bilateral breast carcinoma. It was probably of metastatic origin, but this was not fully substantiated as histological examination had been performed on only one breast; however, according to the gross descriptions, both breast masses were similar.…”
Section: Reported Cases Of Bilateral Breast Carcinoma Metastatic Frommentioning
confidence: 99%
“…Gynecomastia and decreased testicular function were observed, but no other effects were detected despite careful, repeated examinations. Subsequently, there appeared a number of reports which described development of breast neoplasms in male patients who had received estrogenic substances (2, 7, 16, 29, 40, 42, 46, 54, 57).…”
Section: Bole Of Estrogensmentioning
confidence: 99%