Cancer Nanotechnology in Medicine: A Promising Approach for Cancer Detection and Diagnosis

Stephen, Bjorn John; Suchanti, Surabhi; Mishra, Rajeev; Singh, Abhijeet

doi:10.1615/critrevtherdrugcarriersyst.2020032634

Cited by 21 publications

(7 citation statements)

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“…To date, more than one hundred and sixty biomarkers have been introduced for cancer diagnosis. A lab-on-chip is a biosensor that facilitates the concurrent measurement of numerous biomarkers [ 43 , 44 , 45 , 46 , 47 ]. Advanced microfabrication techniques facilitate the integration of microfluidics with biosensing functionalities on a single sensor chip, allowing system automation.…”

Section: Introductionmentioning

confidence: 99%

Design of a Lab-On-Chip for Cancer Cell Detection through Impedance and Photoelectrochemical Response Analysis

et al. 2022

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In this study, a biochip was fabricated using a light-absorbing layer of a silicon solar element combined with serrated, interdigitated electrodes and used to identify four different types of cancer cells: CE81T esophageal cancer, OE21 esophageal cancer, A549 lung adenocarcinoma, and TSGH-8301 bladder cancer cells. A string of pearls was formed from dielectrophoretic aggregated cancer cells because of the serrated interdigitated electrodes. Thus, cancer cells were identified in different parts, and electron–hole pairs were separated by photo-excited carriers through the light-absorbing layer of the solar element. The concentration catalysis mechanism of GSH and GSSG was used to conduct photocurrent response and identification, which provides the fast, label-free measurement of cancer cells. The total time taken for this analysis was 13 min. Changes in the impedance value and photocurrent response of each cancer cell were linearly related to the number of cells, and the slope of the admittance value was used to distinguish the location of the cancerous lesion, the slope of the photocurrent response, and the severity of the cancerous lesion. The results show that the number of cancerous cells was directly proportional to the admittance value and the photocurrent response for all four different types of cancer cells. Additionally, different types of cancer cells could easily be differentiated using the slope value of the photocurrent response and the admittance value.

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Section: Introductionmentioning

confidence: 99%

Design of a Lab-On-Chip for Cancer Cell Detection through Impedance and Photoelectrochemical Response Analysis

et al. 2022

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“…The nanotechnology applied to cancer diagnosis and treatment emerged as a promising alternative with the potential of successfully combining the advances made at the nanoscale with cellular and molecular components that may allow overcoming the physiological and technological limits of conventional cancer treatment modalities. This approach has facilitated the coupling of nanoparticles (NPs) synthesized via the green biological pathway with target molecules, allowing an efficient interaction with biological systems [ 7 ]. In most cases, NPs are part of a complex multishell cancer cell targeting delivery system that serves as antineoplastic drug nanocarrier [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Green Metallic Nanoparticles for Cancer Therapy: Evaluation Models and Cancer Applications

et al. 2021

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Metal-based nanoparticles are widely used to deliver bioactive molecules and drugs to improve cancer therapy. Several research works have highlighted the synthesis of gold and silver nanoparticles by green chemistry, using biological entities to minimize the use of solvents and control their physicochemical and biological properties. Recent advances in evaluating the anticancer effect of green biogenic Au and Ag nanoparticles are mainly focused on the use of conventional 2D cell culture and in vivo murine models that allow determination of the half-maximal inhibitory concentration, a critical parameter to move forward clinical trials. However, the interaction between nanoparticles and the tumor microenvironment is not yet fully understood. Therefore, it is necessary to develop more human-like evaluation models or to improve the existing ones for a better understanding of the molecular bases of cancer. This review provides recent advances in biosynthesized Au and Ag nanoparticles for seven of the most common and relevant cancers and their biological assessment. In addition, it provides a general idea of the in silico, in vitro, ex vivo, and in vivo models used for the anticancer evaluation of green biogenic metal-based nanoparticles.

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“…Cancer is one of the leading causes of death in the world [1], and over the past decades, intensive efforts have been made to develop new and effective methods for the diagnosis and treatment of cancer [2][3][4][5]. Surgery, radiation, and chemotherapy are the main classical techniques for cancer treatment [6,7].…”

Section: Introduction To Cancer-nano-interactionsmentioning

confidence: 99%

Cancer-Nano-Interaction: From Cellular Uptake to Mechanobiological Responses

Kashani

Packirisamy

2021

IJMS

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With the advancement of nanotechnology, the nano-bio-interaction field has emerged. It is essential to enhance our understanding of nano-bio-interaction in different aspects to design nanomedicines and improve their efficacy for therapeutic and diagnostic applications. Many researchers have extensively studied the toxicological responses of cancer cells to nano-bio-interaction, while their mechanobiological responses have been less investigated. The mechanobiological properties of cells such as elasticity and adhesion play vital roles in cellular functions and cancer progression. Many studies have noticed the impacts of cellular uptake on the structural organization of cells and, in return, the mechanobiology of human cells. Mechanobiological changes induced by the interactions of nanomaterials and cells could alter cellular functions and influence cancer progression. Hence, in addition to biological responses, the possible mechanobiological responses of treated cells should be monitored as a standard methodology to evaluate the efficiency of nanomedicines. Studying the cancer-nano-interaction in the context of cell mechanics takes our knowledge one step closer to designing safe and intelligent nanomedicines. In this review, we briefly discuss how the characteristic properties of nanoparticles influence cellular uptake. Then, we provide insight into the mechanobiological responses that may occur during the nano-bio-interactions, and finally, the important measurement techniques for the mechanobiological characterizations of cells are summarized and compared. Understanding the unknown mechanobiological responses to nano-bio-interaction will help with developing the application of nanoparticles to modulate cell mechanics for controlling cancer progression.

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Cancer Nanotechnology in Medicine: A Promising Approach for Cancer Detection and Diagnosis

Cited by 21 publications

References 0 publications

Design of a Lab-On-Chip for Cancer Cell Detection through Impedance and Photoelectrochemical Response Analysis

Design of a Lab-On-Chip for Cancer Cell Detection through Impedance and Photoelectrochemical Response Analysis

Green Metallic Nanoparticles for Cancer Therapy: Evaluation Models and Cancer Applications

Cancer-Nano-Interaction: From Cellular Uptake to Mechanobiological Responses

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