Cancer-macrophage hybrid membrane-camouflaged photochlor for enhanced sonodynamic therapy against triple-negative breast cancer

Zhang, Lishan; Yin, Ting; Zhang, Baozhen; Yan, Chong; Lu, Chengyu; Liu, Lanlan; Chen, Ze; Hui, Ran; Shi, Qingxia; Pan, Hong; Ma, Aiqing; Cai, Lintao

doi:10.1007/s12274-021-4039-y

Cited by 15 publications

(5 citation statements)

References 28 publications

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“…TCMVs carry all the antigenic proteins of tumor cells, but their immunogenicity is low. Researchers have fused TCMVs with biological membranes such as bacterial membranes, dendritic cell membranes and macrophage membranes to improve the immunogenicity of the particles and enhance antigen delivery, obtaining better immune effects [ 2 , 57 , 58 , 59 ].…”

Section: Tumor Cell-derived Membrane Vesiclesmentioning

confidence: 99%

Tumor-Derived Membrane Vesicles: A Promising Tool for Personalized Immunotherapy

Cao

Wang

et al. 2022

Pharmaceuticals

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Tumor-derived membrane vesicles (TDMVs) are non-invasive, chemotactic, easily obtained characteristics and contain various tumor-borne substances, such as nucleic acid and proteins. The unique properties of tumor cells and membranes make them widely used in drug loading, membrane fusion and vaccines. In particular, personalized vectors prepared using the editable properties of cells can help in the design of personalized vaccines. This review focuses on recent research on TDMV technology and its application in personalized immunotherapy. We elucidate the strengths and challenges of TDMVs to promote their application from theory to clinical practice.

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Section: Tumor Cell-derived Membrane Vesiclesmentioning

confidence: 99%

Tumor-Derived Membrane Vesicles: A Promising Tool for Personalized Immunotherapy

Cao

Wang

et al. 2022

Pharmaceuticals

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“…Other types of membranes consisting of macrophage membrane, [198] red blood cell membrane, [199] 4T1 cancer cell-macrophage hybrid membrane. [200] The amelioration of tumor hypoxia plays a decisive role in the enhancement of SDT effect. Based on this background, a series of biomimetic O 2 supply nanoplatform are gradually being explored.…”

Section: Biomimetic Sonodynamic Therapymentioning

confidence: 99%

“…Other types of membranes consisting of macrophage membrane, [ 198 ] red blood cell membrane, [ 199 ] 4T1 cancer cell‐macrophage hybrid membrane. [ 200 ]…”

Section: Nanobiomimetic Medicine For Cancer Therapymentioning

confidence: 99%

Nanobiomimetic Medicine

Chang

Dong

Huang

et al. 2022

Adv Funct Materials

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The application of nanotechnology in medicine aims at developing the precise theranostics of diseases by leveraging the extraordinary effects of engineered nanomedicines, materdicine, and biomaterials. However, finely controlling the biological behavior of nanomaterials in the complex living systems remains a great challenge in terms of accuracy and intelligence. Inspired by nature, biomimetics has become an attractive strategy based on the highly ordered natural biological structure for the development of clinically valuable materials and technologies, arising from the superior bioavailability. The rapid development of biomimetics in nanomedical applications prompts the authors to propose the concept of “nanobiomimetic medicine”, which is a considerable subdiscipline in nanomedicine and materdicine that applies the concept and strategies of biomimetics to facilitate and promote the disease theranostics. Herein, the authors aim to furnish a state‐of‐the‐art review on the latest progress in the field of nanobiomimetic medicine. The design strategies, structural features and biological properties of biomimetic materials are initially introduced to reveal the inherent bionic mechanism and the potential structure‐function relationships. Furthermore, advances with respect to the applications of diverse biomimetic materials are comprehensively summarized. Finally, the current challenges and future direction of nanobiomimetic medicine are discussed and prospected in order to stimulate more biomimetic fundamental and technological breakthroughs in nanomedicine.

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“…PHNPs@ HM expressed the membrane proteins of both cancer cells and macrophages, remarkably boosting the effective targeting and endocytosis to 4T1 cells through homologous adhesion recognition and immune escaping. Hybrid membrane NPs generated amount of reactive oxygen species (ROS) under ultrasound (US) irradiation and exhibited obvious SDT efficiency to inhibit 4T1 tumor growth via ROS-inducing cell apoptosis (L. S. Zhang et al, 2022). Besides to immune cells, cancer cell can also combine with transport cells to produce the multi-functional hybrid membrane NPs.…”

Section: Hybrid Cell Membrane Nanoengineering For Multi-target Immune...mentioning

confidence: 99%

Cell surface‐nanoengineering for cancer targeting immunoregulation and precise immunotherapy

Wang

Huang

Hou

et al. 2022

WIREs Nanomed Nanobiotechnol

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Living cells have become ideal therapeutic agents for cancer treatment owing to their innate activities, such as efficient tumor targeting and delivery, easy engineering, immunomodulatory properties, and fewer adverse effects. However, cell agents are often fragile to rigorous tumor microenvironment (TME) and limited by inadequate therapeutic responses, leading to unwanted treatment efficacy. Cell nanomodification, particularly the cell surfacenanoengineering has emerged as reliable and efficient strategy that not only combines cell activity properties with nanomaterials but also endows them with extra novel functions, enabling to achieve remarkable treatment results. In this review, we systematically introduce two major strategies have been adopted to develop cell surface engineering with nanomaterials, mainly including living cell nano-backpacks and cell membrane-mimicking nanoparticles (NPs). Based on various functional NPs and cell types, we focus on reviewing the cell-surface nanoengineering for targeted drug delivery, immune microenvironment regulation, and precisely antitumor therapy. The advances and challenges of cell surface-nanoengineered antitumor agents for cancer therapy applications are further discussed in future clinical practice. This review provides an overview of the advances in cell surface-engineering for targeting immunoregulation and treatment and could contribute to the future of advanced cell-based antitumor therapeutic applications.

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Cancer-macrophage hybrid membrane-camouflaged photochlor for enhanced sonodynamic therapy against triple-negative breast cancer

Cited by 15 publications

References 28 publications

Tumor-Derived Membrane Vesicles: A Promising Tool for Personalized Immunotherapy

Tumor-Derived Membrane Vesicles: A Promising Tool for Personalized Immunotherapy

Nanobiomimetic Medicine

Cell surface‐nanoengineering for cancer targeting immunoregulation and precise immunotherapy

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