Cancer Incidence and Mortality Survey in Wuwei, Gansu Province, Northwestern China from 2003 to 2012

Abstract

Background:Population-based cancer registry collects the data on cancer incidence and mortality deaths from covered population to describe and survey the epidemics in certain areas. The aim of this study was to estimate the cancer incidence and mortality in Wuwei, Gansu province, Northwestern China from 2003 to 2012. The goal is to better understand cancer distribution and long-term development of cancer prevention and treatment in Wuwei.Methods:Data were collected from the Wuwei Cancer Registry between 2003 and 2012. In this registry, data from 46 cancer report centers were included in this analysis. Incidence/mortality rates, age-specific incidence/mortality rates, age-standardized incidence/mortality rates, and cumulative incidence/mortality rates were calculated. Totally, 9,836,740 person-years (5,110,342 for males and 4,726,398 for females) had been monitored over this time period. The gender ratio of male/female was 1.08:1. The number of new cancer cases and related deaths was 24,705 and 17,287 from 2003 to 2012, respectively.Results:The proportion of morphological verification was 74.43%. The incidence of cases identified through death certification only was 1.21%, and the mortality to incidence ratio was 0.70. The average crude incidence was 251.15/100,000 persons (310.61 and 186.87 for males and females per 100,000 persons, respectively). The age-standardized rates by Chinese standard population (ASR-China) and by world standard population (ASR-world) were 207.76 and 245.42 per 100,000 persons, respectively. The crude cancer mortality was 175.74/100,000 persons (228.34 and 118.86 for males and females per 100,000 persons). ASR for China and the world was 149.57 and 175.13/100,000 persons, respectively. The most common cancers and leading causes of cancer-related deaths in Wuwei were as follows: cancers of stomach, esophagus, liver, lung, colorectum, breast, cervix, lymphoma, blood (leukemia), brain, and central nervous system. In Wuwei, during 2003 and 2012, cancer incidence and mortality rates increased by 1.32% and 1.31%/year, respectively. During this time, colorectum cancer incidence and mortality rates increased by 2.69% and 7.54%/year, respectively, in Wuwei. The incidence and mortality of other gastric, esophageal, liver, and lung cancers also all increased.Conclusions:The results of this study report a more accurate cancer burden among the population of Wuwei, China. Active research of cancers etiology and effective prevention should be established to reduce the incidence and mortality associated with cancers.

Incidence of Cancer in Shenzhen, Guangdong Province during 2001–2015: A Retrospective Population-Based Study

“…The age-specific incidence rates in males were all lower than females for individuals 25–54 years old, while for individuals over 55 years old, the age-specific incidence rates in males were all much higher than females. The results are consistent with those in some studies [ 3 , 7 , 18 ], which showed that the cancer incidence increased gradually with age and cancer incidence was higher in males than females over 50 years old. The results could be attributed to some risk factors.…”

“…There are some factors that are possibly contributing to the growing incidence and mortality of cancer in developing countries, which include population aging and growth, smoking, physical inactivity, unhealthy diets, environment pollution and occupation exposure [ 4 , 5 , 6 ]. In particular, the environment pollution, high density population and bad health lifestyles are still serious problems need to be solved in China, which contribute to the obvious increase in the incidence of cancer [ 7 ]. Thus, obtaining knowledge about the situation of cancer and controlling the growth in the incidence of cancer are goals that the governments around the world should achieve.…”

<p>Curcumin Affects Gastric Cancer Cell Migration, Invasion and Cytoskeletal Remodeling Through Gli1-β-Catenin</p>

“…1 Gastric cancer is one of the most common types of cancer according to a ten-year tumor statistics analysis from Wuwei district, Gansu province, China. 2 Most patients with gastric cancer are diagnosed at an advanced stage due to lack of early symptoms and the limitations in screening programs. 3 However, lack of effective treatments for gastric cancer and the challenge of chemotherapy resistance are still great problems in gastric cancer therapy.…”

National Cancer Mortality-to-Incidence Ratio (MIR) in Iran (2005 - 2014)

“…According to the report of world health organization (WHO), the number of cancer-related deaths was 6 million in 2000, 7.6 million in 2005, and 7.9 million 2007, and this reveals 32% growth in the number of deaths during 2000 to 2007 (9). In 2007, 13% of the deaths were assigned to cancer and 72% occurred in developing countries (10)(11)(12)(13)(14).…”

“…Considering this growth in incidence rate, there will be 13 million cancer-related deaths in 2030, 9 million of which will occur in developing countries (15). Increasing in the cancer burden mainly depends on the growth of population and aging (increasing in life expectancy) (3, 4, 13-21) also, risk factors and harmful life style (10,13,14,20). Changing in fertility rate (4,20) and life expectancy are two main factors affecting population pyramid (22), which can cause problems in countries with different levels of financial supports and funds.…”