Cancer Incidence and Incidence Rates in Japan in 2006: Based on Data from 15 Population-based Cancer Registries in the Monitoring of Cancer Incidence in Japan (MCIJ) Project

Matsuda, Tomohiro; Marugame, Tomomi; Kamo, Ken-ichi; Katanoda, Kota; Ajiki, Wakiko; Sobue, Tomotaka

doi:10.1093/jjco/hyr184

Cited by 174 publications

(128 citation statements)

References 7 publications

Supporting

Mentioning

126

Contrasting

Order By: Relevance

“…The prevalence rates per 100,000 for oral and pharyngeal cancer and for uterine cervical cancer according to national statistics are illustrated in Figure 5. 20 The reasons for these increases in the number of oral and pharyngeal cancers and uterine cervical cancers after 2000 are unclear but may be related to the westernization of sexual habits. In other Asian countries, the p16-positive rate is reportedly 49.5% in Korea 21 and 29% in Hong Kong.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of p16 expression and alcohol consumption in Japanese patients with oropharyngeal squamous cell carcinoma

Saito

Yoshida

Ushiku

et al. 2013

Cancer

View full text Add to dashboard Cite

BACKGROUND:The prevalence and prognostic value of human papillomavirus-related oropharyngeal squamous cell carcinoma (OPSCC) in Japan has not been evaluated. METHODS: Over a 12-year period, the authors used immunohistochemistry to evaluate the expression of p16 (a cyclin-dependent kinase inhibitor and tumor suppressor) in samples from 173 patients with OPSCC at a single institution and to determine its prevalence and influence on disease prognosis. RESULTS: The prevalence of p16-positive OPSCC was 33.7% in tonsillar carcinoma, 28.6% in tongue base carcinoma, 0% in posterior wall carcinoma, and 18.8% in soft palate carcinoma. The prevalence of p16-positive OPSCC tumors increased from 15.2% during 2000 to 2003 up to 33.3% during 2008 to 2011; during the same periods, among nonsmokers, the prevalence of p16-positive OPSCC tumors increased from 21.2% to 27.8%; and, among nondrinkers, prevalence increased from 6.1% to 25%. Multivariate analysis identified p16 expression and alcohol consumption as significant, independent prognostic markers of OPSCC. CONCLUSIONS: The current results suggest that the incidence of human papillomavirus-related OPSCC in Japan is increasing and indicate that p16 expression and alcohol consumption may be significant prognostic markers of survival for patients with OPSCC in Japan. Cancer 2013;119:2005-11. V C 2013 American Cancer Society.KEYWORDS: oropharyngeal carcinoma, head and neck squamous cell carcinoma, p16, human papillomavirus, alcohol consumption, Japan. INTRODUCTIONTobacco smoking and excessive alcohol consumption traditionally have been considered the main risk factors for head and neck squamous cell carcinoma (HNSCC). Oral and oropharyngeal squamous cell carcinoma (OPSCC) are major causes of morbidity, with an estimated annual worldwide incidence of 300,000. Evidence suggests that human papillomavirus (HPV) infection is also an independent risk factor, especially for OPSCC. [1][2][3][4][5][6] Most of the available data on HPVassociated SCC were generated in the United States and Europe. The incidence of HPV-associated malignancies, such as carcinoma of the uterine cervix, varies substantially in different regions of the world; for example, the incidence of HPVrelated cervical/uterine cancer is higher in African and Asian countries than in European countries. 7 Although eastern Asia, including Japan, is known for high epidemics of several oncogenic viral infections, such as Epstein-Barr virus and hepatitis B virus, the status of HPV-related SCC in Asia has not been elucidated.The diagnosis of HPV-related OPSCC can be made using polymerase chain reaction (PCR) analysis to detect HPV DNA 2 ; however, although this is a logical approach, it is quite challenging in clinical practice. Other diagnostic methods are HPV in situ hybridization or quantification of expression of the HPV oncoproteins E6 and E7, which has the major advantage of detecting transcriptionally active HPV. These assays, however, are cumbersome, costly, and require highly trained personnel. 8 A more feasible diagnos...

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic value of p16 expression and alcohol consumption in Japanese patients with oropharyngeal squamous cell carcinoma

Saito

Yoshida

Ushiku

et al. 2013

Cancer

View full text Add to dashboard Cite

show abstract

“…Although its incidence is decreasing, gastric cancer is still the second most frequent cause of cancer-related death in Japan [1,2]. The prognosis of patients with advanced gastric cancer remains poor, and the median survival time of patients with inoperable and/or gastric cancer is \1 year [3,4].…”

Section: Introductionmentioning

confidence: 99%

Expression profiles of HER2, EGFR, MET and FGFR2 in a large cohort of patients with gastric adenocarcinoma

et al. 2014

View full text Add to dashboard Cite

Background Some tyrosine kinase receptors (RTKs) play critical roles in gastric cancer progression. Not only trastuzumab, but also several other agents targeting RTKs are being investigated for gastric cancer therapy. However, the simultaneous expression of multiple RTKs, which may interfere with the effectiveness of therapeutic agents, has not been evaluated in a large cohort with gastric adenocarcinoma (GAC). Methods We performed a tissue microarray analysis in 950 patients with GAC who underwent a gastrectomy without preoperative chemotherapy. The protein expressions of HER2, EGFR, MET and FGFR2 were evaluated using immunohistochemistry, and the gene amplifications of HER2, EGFR and MET were examined using dual-color in situ hybridization.Results The frequency of overexpression was 11.8 % for HER2, 23.5 % for EGFR, 24.9 % for MET and 31.1 % for FGFR2. Whereas strong staining for each of the RTKs was heterogeneous, tumors with homogeneously strong staining areas often exhibited gene amplification. Strong EGFR expression was significantly associated with a poor outcome, but no prognostic correlations were observed in other RTKs. The overexpression of single and multiple RTKs was observed in 40.4 and 22.7 % of the cases, respectively. HER2, EGFR, MET and FGFR2 predominance was observed in 10.1, 13.9, 16.1 and 22.9 % of the GACs, respectively. Conclusions Approximately two-thirds of patients with GAC exhibited the expression of at least one RTK and would be candidates for targeted therapies. Moreover, one-third of at least one RTK overexspressing cases showed multiple RTKs expression. Our results may be useful for selecting the most suitable patients for each targeted therapy.

show abstract

“…In their report, the total incidence of cancer in Japan for 2006 was estimated as 664,398, and the incidence of cancer continues to increase (Matsuda et al, 2012). Since the early 2000s, the age-standardized incidence rates in all cancer sites have slightly increased, whereas they remained unchanged in the 1990s.…”

Section: Introductionmentioning

confidence: 99%

Physical Functions, Health-Related Outcomes, Nutritional Status, and Blood Markers in Community-Dwelling Cancer Survivors Aged 75 Years and Older

Ihira

Mizumoto²,

Makino³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: A cancer survivor is defined as anyone who has been diagnosed with cancer, from the time of diagnosis through the rest of their life. The purpose of this study was to examine whether physical functions, health-related outcomes, nutritional status and blood markers in community-dwelling cancer survivors aged 75 years and older are different from those who do not have cancer Materials and Methods: Two hundred seventy-five participants were asked by physicians, nurses, and physical therapists, questions regarding cancer history in a face-to-face interview. Data were collected for demographic information, physical functions, such as handgrip strength, knee extension power, abdominal muscle strength, static standing balance, walking speed and the timed-up-and-go test, health-related outcomes, nutritional status, and blood markers. The measured parameters of survivor diagnosed with cancer were compared with those without a history of cancer. Results: Thirty-seven older adults were previously diagnosed with cancer. Female cancer survivors had lower knee extension power (p<0.05), abdominal muscle strength (p<0.05), walking speed (p<0.05), timed-up-and-go test score (p<0.05), and time to spend on walking per day (p<0.05) than older women without a history of cancer. In men, none of the measured parameters were significantly different between cancer survivors and older men with no history of cancer. Conclusions: The present study shows that partial physical function of women cancer survivors aged 75 years and older differs from that in women with no history of cancer.Keywords: Cancer survivor -health-related quality of life -older women -physical function

show abstract

Cancer Incidence and Incidence Rates in Japan in 2006: Based on Data from 15 Population-based Cancer Registries in the Monitoring of Cancer Incidence in Japan (MCIJ) Project

Cited by 174 publications

References 7 publications

Prognostic value of p16 expression and alcohol consumption in Japanese patients with oropharyngeal squamous cell carcinoma

Prognostic value of p16 expression and alcohol consumption in Japanese patients with oropharyngeal squamous cell carcinoma

Expression profiles of HER2, EGFR, MET and FGFR2 in a large cohort of patients with gastric adenocarcinoma

Physical Functions, Health-Related Outcomes, Nutritional Status, and Blood Markers in Community-Dwelling Cancer Survivors Aged 75 Years and Older

Contact Info

Product

Resources

About