Physical Functions, Health-Related Outcomes, Nutritional Status, and Blood Markers in Community-Dwelling Cancer Survivors Aged 75 Years and Older

Ihira, Hikaru; Mizumoto, Atsushi; Makino, Keitaro; Yasuda, Keisuke; Yoko, Yoko; Saitoh, Shigeyuki; Ohnishi, Hirofumi; Furuna, Taketo

doi:10.7314/apjcp.2014.15.7.3305

Cited by 14 publications

(20 citation statements)

References 37 publications

(33 reference statements)

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“…Cheung et al 3 and Ihira et al 16 did not find an association between handgrip strength and cancer. However, Norman et al 6 showed that malnourished cancer patients had a lower handgrip strength.…”

Section: Discussionmentioning

confidence: 91%

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Chronic diseases, multimorbidity, and handgrip strength among older adults from Southern Brazil

2016

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A B S T R A C T ObjectiveTo investigate the association between various chronic diseases, multimorbidity, and handgrip strength in community dwelling older adults in Southern Brazil. MethodsA cross-sectional study carried out with 477 older adults (60 years and older) who resided in Antônio Carlos, Santa Catarina state. Subjects aged 60-79 years were selected by probability sampling (n=343) and all subjects aged 80 years or older (n=134) were evaluated. Chronic diseases were identified by self-report. A mechanical dynamometer verified handgrip strength (i.e., the outcome). Adjustments variables were age, literacy, living arrangement, smoking, body mass index, cognitive function, and comorbid chronic diseases. Sex-stratified analyses were conducted with simple and multiple linear regression. ResultsA total of 270 women (73.2±8.8 years) and 207 men (73.3±9.0 years) were assessed. In the adjustment analysis, cancer (β=-3.69; 95%CI=-6.97 to -0.41) and depression (β=-1.65; 95%CI=-3.20 to -0.10) were associated with lower handgrip strength in women. For men, diabetes (β=-5.30; 95%CI=-9.64 to -0.95), chronic lung disease (β=-4.74; 95%CI=-7.98 to -1.50), and coronary heart disease (β=-3.07; 95%CI=-5.98 to -0.16) were

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Section: Discussionmentioning

confidence: 91%

“…Data were double entered in Statistical Package for the social Sciences (SPSS Inc., Chicago, Illinois, United States) 16.0 program and the analyses were performed using Stata (Stata Corporation, College Station, Texas, United States) 11.0 software. The analyses were weighted by poststratification weights to account for the sampling design.…”

Section: E T H O D Smentioning

confidence: 99%

Chronic diseases, multimorbidity, and handgrip strength among older adults from Southern Brazil

2016

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“…The present prospective cohort study involved 411 community‐dwelling people aged ≥75 years enrolled in the project “Population‐based and Inspiring Potential Activity for Old‐old Inhabitants (PIPAOI)” from 2012 to 2013. This study was carried out in Bibai city (Japan), and the details of the PIPAOI project have been described previously . The inclusion criteria for the PIPAOI were being aged ≥75 years and residing in Bibai city (Japan).…”

Section: Methodsmentioning

confidence: 99%

Structural analysis of impact of physical, cognitive and social status on the incidence of disability in community‐dwelling people aged ≥75 years

Makino

Ihira²,

Mizumoto³

et al. 2018

Geriatrics Gerontology Int

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Aim The present study aimed to propose a structural model to explain the interaction of physical, cognitive and social domains of health status in the incidence of disability in community‐dwelling people aged ≥75 years. Methods We analyzed 185 older adults (mean age 79.4 years, 58.4% female) who participated in a baseline assessment from 2012 to 2013. They were followed for incident certification of care needs in the national long‐term care insurance certification system during the 2 years. Baseline assessments included several measurements related to the physical, cognitive and social domains of health status. We compared the model fit index between two hypothesis models – the parallel model and the hierarchical model – using structural equation modeling. Results During the follow‐up period, 15 participants (8.1%) were newly certified as requiring personal support from the long‐term care insurance system. The structural equation modeling showed that the hierarchical model, indicating that cognitive and social status were indirectly associated with disability through physical status, had a better fit with the data than the parallel model, indicating that physical, cognitive and social status each were directly associated with disability. Conclusions The present results suggest that cognitive and social status might indirectly affect disability incidence through physical aging. Further research is required to examine the temporal relationship between physical, cognitive and social change using data over several time‐periods. Geriatr Gerontol Int 2018; 18: 1614–1619.

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“…Markers of nutritional status have been predictive of outcomes in gastrointestinal cancers (6)(7)(8). Specifically, body mass index (BMI) has been widely evaluated due to its ability to normalize for patient height (9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Impact of sarcopenia in borderline resectable and locally advanced pancreatic cancer patients receiving stereotactic body radiation therapy

Jin¹,

Mellon²,

Frakes³

et al. 2018

J. Gastrointest. Oncol.

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Background: Total psoas area (TPA), a marker of sarcopenia, has been used as an independent predictor of clinical outcomes in gastrointestinal (GI) cancers as a proxy for frailty and nutritional status. Our study aimed to evaluate whether TPA, in contrast to traditional measurements of nutrition like body mass index (BMI) and body surface area (BSA), was predictive of outcomes in borderline resectable pancreatic cancer (BRPC) and locally advanced pancreatic cancer (LAPC) patients receiving stereotactic body radiation therapy (SBRT). Methods: Retrospective analysis of an institutional review board approved database of 222 BRPC and LAPC treated with SBRT from 2009-2016 yielded 183 patients that met our selection criteria of pre-SBRT computed tomography (CT) imaging with an identifiable L4 vertebra. Once the L4 vertebral level was identified, the bilateral psoas muscles were manually contoured. This area was normalized by patient height, with units described in mm 2 /m 2 . Receiver operating characteristic (ROC) curves were generated for TPA, BMI, and BSA to elicit clinically relevant cutoffs. Regression and Kaplan-Meier analyses were used to correlate toxicity with survival functions.Results: Low TPA (OR =1.903, P=0.036) was predictive of acute toxicities, and only TPA was predictive of Grade 3 or higher acute toxicities (OR =10.24, P=0.007). Both findings were independent of tumor resectability. Pain (P=0.003), fatigue (P=0.040), and nausea (P=0.039) were significantly associated with low TPA. No association was identified between any measurement of nutritional status and the development of late toxicities, overall survival, local progression or local recurrence. However, BRPC patients survived longer (median =21.98 months) than their LAPC (median =16.2 months) counterparts (P=0.002), independent of nutritional status. Conclusions: TPA measurement is readily available and more specific than BMI or BSA as a predictor of acute radiotoxic complications following SBRT in BRPC/LAPC patients. A TPA of <500 mm 2 /m 2 is a clinically relevant cutoff that can direct physicians to address expected complications of pain, fatigue, and nausea. However, tumor resectability remains as the only predictor of overall survival in this cohort.

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Physical Functions, Health-Related Outcomes, Nutritional Status, and Blood Markers in Community-Dwelling Cancer Survivors Aged 75 Years and Older

Cited by 14 publications

References 37 publications

Chronic diseases, multimorbidity, and handgrip strength among older adults from Southern Brazil

Chronic diseases, multimorbidity, and handgrip strength among older adults from Southern Brazil

Structural analysis of impact of physical, cognitive and social status on the incidence of disability in community‐dwelling people aged ≥75 years

Impact of sarcopenia in borderline resectable and locally advanced pancreatic cancer patients receiving stereotactic body radiation therapy

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