Cancer Incidence and Incidence Rates in Japan in 2005: Based on Data from 12 Population-based Cancer Registries in the Monitoring of Cancer Incidence in Japan (MCIJ) Project

Matsuda, T; Marugame, Tomomi; Kamo, Ken-ichi; Katanoda, Kota; Ajiki, Wakiko; Sobue, Tomotaka

doi:10.1093/jjco/hyq169

Cited by 150 publications

(99 citation statements)

References 5 publications

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“…Pancreatic cancer is one of the cancers with the worst prognosis. Difficulty in early detection of small changes means that the average 5-year survival is only 5.5% [22]. Endoscopic ultrasonography is a diagnostic method that has a higher sensitivity than CT and MRI.…”

Section: Focal Pancreatic Changesmentioning

confidence: 99%

The role of endoscopic ultrasonography (EUS) in contemporary diagnosis of gastrointestinal diseases

Kiełtucki¹,

Wawrzyniec²

2016

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Day by day endoscopic ultrasonography (EUS) is becoming an essential diagnostic method for the assessment of solid lesions of the pancreas, cysts, pseudocysts and cystic tumours of the pancreas, enlarged mediastinal lymph nodes, staging of gastric cancer and rectal cancer, as well as lung or subepithelial tumours in the gastrointestinal tract. The ability to use this diagnostic method presents many challenges for performing specialists, from the organisation of the EUS surgery to maintaining its activity in a proper technical aspect, as well as the continuous improvement of staff qualifications. Endoscopic ultrasonography has revolutionised the practical aspects of gastroenterological practice and oncology. Particularly, EUS-guided fine-needle aspiration biopsy (EUS-FNA) of various pathologies in the gastrointestinal tract has provided invaluable effects and opportunities. This technique is becoming more and more available in Poland, creating a unique challenge to its practice. StreszczenieUltrasonografia endoskopowa (EUS) staje się z dnia na dzień kluczową metodą diagnostyczną zmian litych w trzustce, torbieli, pseudotorbieli i guzów torbielowatych trzustki, powiększonych węzłów chłonnych śródpiersia, zaawansowania raka żołądka, odbytnicy, jak również nowotworów płuc i zmian podnabłonkowych w przewodzie pokarmowym. Technika ta stawia przed wykonującymi badanie wiele wyzwań -zorganizowanie pracowni EUS, utrzymanie jej działania na należytym poziomie technicznym czy stałe podnoszenie kwalifikacji personelu. Ultrasonografia endoskopowa zrewolucjonizowała praktyczne aspekty diagnostyki gastroenterologicznej i onkologicznej, zwłaszcza biopsja cienkoigłowa kontrolowana ultrasonografią endoskopową (EUS-FNA) różnego rodzaju zmian w obrębie przewodu pokarmowego daje nieocenione efekty i możliwości. Metoda ta jest coraz bardziej dostępna w Polsce, zwiększają się również możliwości jej praktycznego doskonalenia.

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Section: Focal Pancreatic Changesmentioning

confidence: 99%

The role of endoscopic ultrasonography (EUS) in contemporary diagnosis of gastrointestinal diseases

Kiełtucki¹,

Wawrzyniec²

2016

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“…In Japan, one out of every two persons is eventually diagnosed with some form of cancer (Matsuda et al, 2011). Because cancer is a disease of national importance, countermeasures are urgently needed.…”

Section: Breast Cancer Smr and Sir In Kanagawa Above Smr Below Sirmentioning

confidence: 99%

Breast Cancer Clustering in Kanagawa, Japan: A Geographic Analysis

Katayama

Yokoyama²,

Yako-Suketomo³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The purpose of the present study was to determine geographic clustering of breast cancer incidence in Kanagawa Prefecture, using cancer registry data. The study also aimed at examining the association Materials and Methods: Incidence data were collected (e.g., city, special ward, town, and village) in Kanagawa by an indirect method using Kanagawa female population data. Spatial scan statistics were used to detect any area of elevated risk as a cluster for breast cancer deaths and/ regions. Results:incidence in southeastern area of Kanagawa Prefecture. It was suggested that the cluster region was related to the tendency to marry later. This study methodology will be helpful in the analysis of geographical disparities in cancer deaths and incidence.

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“…Although therapies for OSCC have recently been improved, only slight progress has been observed in the mortality rates over the last two decades (2). The most important prognostic factor in OSCC is the presence of lymph node metastasis (LNM).…”

Section: Introductionmentioning

confidence: 99%

Loss of NKX3-1 as a potential marker for an increased risk of occult lymph node metastasis and poor prognosis in oral squamous cell carcinoma

et al. 2012

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Abstract. The prognosis of oral squamous cell carcinoma (OSCC) is significantly dependent on the existence of cervical lymph node metastasis (LNM), with the overall survival rate being much lower in patients with LNM. Primary causes and molecular mechanisms of LNM are still largely unclear. We hypothesized that factors related with cancer progress and/or prognosis in OSCC are revealed by genome-wide investigation of DNA copy number aberrations (CNAs). In order to find biomarkers for occult LNM of OSCC, we comprehensively investigated genomic DNAs from 60 OSCC patients using Affymetrix mapping arrays and statistically analyzed correlations between CNAs of genes and the presence of occult LNM in the patients. The genome-wide CNA study indicated significant correlations between the presence of occult LNM and CNAs of certain genes. Through a literature survey, we narrowed down the candidates and focused on loss of NKX3-1, which is a homeodomain-containing transcription factor. NKX3-1 is known as a tumor suppressor gene in prostate cancer but has never been reported in OSCC. Quantitative RT-PCR and immunohistochemistry (IHC) analyses also showed significantly lower expression of NKX3-1 in the cases with occult LNM, which was further validated by IHC analysis in independent cases. The survival analyses indicated that NKX3-1 loss is a significant risk factor to decrease the diseasefree survival (DFS) and the overall survival (OS) rates. This is the first time that the significant association of NKX3-1 loss and occult LNM was indicated in OSCC. The present results suggest that loss of NKX3-1 may be a potential biomarker for occult LNM of OSCC. IntroductionOral squamous cell carcinoma (OSCC) is the most common head and neck carcinoma, accounting for more than 260,000 cases worldwide each year (1). Although therapies for OSCC have recently been improved, only slight progress has been observed in the mortality rates over the last two decades (2). The most important prognostic factor in OSCC is the presence of lymph node metastasis (LNM). In fact, the 5-year overall survival rate in patients with LNM is approximately 25% lower than in patients without LNM (3). Especially, nodal metastasis diagnosed after surgical resection of a primary tumor site is more severe for survival and known as occult LNM even when the patient is diagnosed without cervical LNM (N0 neck) at the first visit. Therefore, the appropriate management of occult LNM is required and currently two major approaches are applied to manage the N0 neck in OSCCs; an elective neck dissection of cervical lymph node(s) and a 'wait-and-see' policy (4,5). In a case of stage N0 neck with a risk of occult LNM greater than 20%, neck dissection is a standard procedure for elective treatment (6). The risk of metastatic potential can vary according to the site, size, histopathological and genetic features of a primary tumor. Much controversy exists over the decision of the treatment with or without a preventive lymphadenectomy based on accurate risk stratification of potentia...

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Cancer Incidence and Incidence Rates in Japan in 2005: Based on Data from 12 Population-based Cancer Registries in the Monitoring of Cancer Incidence in Japan (MCIJ) Project

Cited by 150 publications

References 5 publications

The role of endoscopic ultrasonography (EUS) in contemporary diagnosis of gastrointestinal diseases

The role of endoscopic ultrasonography (EUS) in contemporary diagnosis of gastrointestinal diseases

Breast Cancer Clustering in Kanagawa, Japan: A Geographic Analysis

Loss of NKX3-1 as a potential marker for an increased risk of occult lymph node metastasis and poor prognosis in oral squamous cell carcinoma

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