Cancer Incidence after Radiotherapy for Skin Haemangioma During Infancy

Lindberg, S.; Karlsson, Per; Arvidsson, Björn; Holmberg, Erik; Lundberg, Lena Marie; Wallgren, Arne

doi:10.3109/02841869509127180

Cited by 95 publications

(50 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore the exposure to ultraviolet radiation is the most common cause of this type of cancer, but several other factors even promote the development of a SCC on the skin. 2,3,8,9 Ionizing radiation has also been implicated in the pathogenesis of squamous-cell carcinoma. In the 1940s and 1960s ionizing radiation was used to treat many cutaneous conditions, including acne, dermatitis and haemangioma.…”

Section: Discussionmentioning

confidence: 99%

“…In the first half of the 20th century the radiotherapy of haemangioma and other benign tumours of the skin was a common method. 4,8,9 The importance of the irradiation of haemangioma in early childhood diminished because of the high spontaneous regression of the haemangioma, located in head and neck area.…”

Section: Discussionmentioning

confidence: 99%

“…In the 1940s and 1960s ionizing radiation was used to treat many cutaneous conditions, including acne, dermatitis and haemangioma. 8,9 The most patients treated with radiotherapy for such a benign tumour were children with a haemangioma in the head and neck. While these treatments generally were effective they resulted in enhanced cancer risks and the use of radiotherapy for benign disease has declined.…”

Section: Discussionmentioning

confidence: 99%

“…5 The development of a deep infiltrating SCC after radiotherapy is not common and the latent period for radiation-induced skin cancer, between 20-40 years, is the problem for exact clinical and statistical evaluation. 9 This case is an example for the late adverse effect of the low-dose radiotherapy of a haemangioma.…”

mentioning

confidence: 99%

See 3 more Smart Citations

A huge infiltrating squamous cell carcinoma of the neck 46 years after radiotherapy of a haemangioma

Scheller¹,

Eckert²,

Scheller³

2010

J Dermatol Case Rep

View full text Add to dashboard Cite

Background: There is a higher risk for malignant tumours in patients who underwent any kind of radiotherapy.Main observations: An 87-year old patient with an extended squamous cell carcinoma of the neck was referred to our hospital. The large ulcerated tumour showed a deep infiltration of the para-vertebral muscles and the spinal processes C6-C7. The tumour was known since about six years and appeared about 46 years after low-dose radiotherapy of a cervical haemangioma of the neck in 1961. The large dimension of the tumour leaded to a radical surgical removal and a sufficient fast reconstruction strategy. The extended defect was covered by a pedicled lower musculocutaneous trapezius flap. No postoperative complications like partial necrosis, infection or movement disorders of the shoulder or a shoulder drop syndrome were seen. Ten weeks after the operation the patient showed a good functional and aesthetic result with no limitation of arm mobility. Two and a half years after radical intended surgery the patient was still alive and showed no recurrence of the tumour.Conclusions: In conclusion there is a need for a life-time lasting dermatological supervision in patients with a history of radiotherapy in the past, because the handling of patients with such an enlarged tumour is complicated.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

A huge infiltrating squamous cell carcinoma of the neck 46 years after radiotherapy of a haemangioma

Scheller¹,

Eckert²,

Scheller³

2010

J Dermatol Case Rep

View full text Add to dashboard Cite

show abstract

“…The great majority of children were treated with 226 Ra tubes, sheets and needles, and a minority received x-ray contact-therapy. The long-term carcinogenic consequences of such treatments are still being studied intensively in Sweden [6,7,8,11,14,15,16], and cohort studies performed for this purpose are now considered one of the major sources of information about the carcinogenic effects of ionizing radiation in infancy.…”

Section: Introductionmentioning

confidence: 99%

Cancer mortality after radiotherapy for a skin hemangioma during childhood

Dondon

2004

Radiotherapy and Oncology

View full text Add to dashboard Cite

Secondary thyroid carcinoma after treatment for childhood cancer

Black

Straaten

Gutjahr

1998

Med. Pediatr. Oncol.

View full text Add to dashboard Cite

Background Second malignant neoplasms (SMNs) have become a primary concern in evaluating long‐term effects of treatment in pediatric oncology. Thyroid carcinoma has proven to be a common SMN. Methods. In a multicenter study involving 58 hospitals in Germany, Austria and Switzerland, 18 of 239 (7.5%) SMNs documented following first malignant neoplasm (FMN) in childhood were thyroid carcinoma. Results. The age at diagnosis of FMN ranged from 1 to 15 years. Eleven patients were female. Six children had survived Hodgkin disease, seven acute leukemia, two Ewing sarcoma and three various other tumors. Fifteen of the 18 patients had been treated with radiotherapy to the head and neck region. The time interval between treatment and diagnosis of thyroid carcinoma ranged from 4 to 19 years (median 8 years). The carcinoma was papillary in 17 cases and follicular in one. Eleven patients had metastases in the regional lymph nodes at presentation. Discussion. Radiotherapy appears to be an important risk factor in secondary thyroid carcinoma, but it does not explain all cases. The current data are remarkable for the large proportion of patients who received only prophylactic cranial irradiation for ALL and for the three patients who received no irradiation to the head and neck region. Genetic determinants and chemotherapy must also be considered. Conclusions. Regular thyroid examination should be included in the long‐term follow‐up of survivors of childhood malignancy. Med. Pediatr. Oncol. 31:91–95, 1998. © 1998 Wiley‐Liss, Inc.

show abstract

Cancer Incidence after Radiotherapy for Skin Haemangioma During Infancy

Cited by 95 publications

References 11 publications

A huge infiltrating squamous cell carcinoma of the neck 46 years after radiotherapy of a haemangioma

A huge infiltrating squamous cell carcinoma of the neck 46 years after radiotherapy of a haemangioma

Cancer mortality after radiotherapy for a skin hemangioma during childhood

Secondary thyroid carcinoma after treatment for childhood cancer

Contact Info

Product

Resources

About