Cancer in women

Abstract

Incidence, mortality and survival trends for the most frequent cancers affecting women are presented on a worldwide basis. Data sources are represented by several different cancer databases, as no single world cancer database covers these epidemiological measures. Monitoring cancer incidence, mortality and survival are fundamental indicators which allow estimates and predictions of geographical and temporal changes of these diseases, enabling the design and set-up of adequate cancer control activities and national health programs. The observed differences in cancer incidence, mortality and survival in more developed countries compared with less developed countries (as defined by WHO) are mainly due to different individual and social risk factors between the two geo-political areas. For some cancers, advancements in screening, diagnosis and treatment in the more developed areas were the most effective factors in reducing incidence and mortality as well as prolonging survival. These effects were not detected in the less developed areas because of the limited access to primary and specialist care.

Identification and Characterization of Ovarian Cancer-Initiating Cells from Primary Human Tumors

“…Ovarian cancer, the most lethal malignancy of the female reproductive system, results annually in over 14,000 U.S. and 114,000 worldwide deaths (1). Greater than 90% of ovarian cancers arise from the surface epithelium (2), and tumorigenesis has been associated with ovulation-associated wound repair and/or inflammation, possibly leading to abnormal stem cell expansion (2,3).…”

Selenium-Binding Protein 1 expression in ovaries and ovarian tumors in the laying hen, a spontaneous model of human ovarian cancer

“…Thus, the role of decreased SELENBP1 in ovarian cancer prognosis is not clear. Ovarian cancer remains the most lethal gynecologic malignancy for women and it represents 2.5% total cancer deaths in the United States [23][24][25][26]. Identifying altered SELENBP1 expression may be significant for the treatment of ovarian cancer since selenium has been shown to have an important role in the reduction and prevention of other cancers.…”

γ-Secretase inhibitor, DAPT inhibits self-renewal and stemness maintenance of ovarian cancer stem-like cells in vitro

“…Ovarian cancer is the leading cause of death due to gynecological cancer [1] . Recurrence and chemoresistance are the major burdens in the treatment of ovarian cancer.…”