Cancer in pregnancy. Part II: treatment options of breast and other non-gynecological malignancies

Hoellen, Friederike; Reibke, Roland; Hornemann, Katrin; Thill, Marc; Luedders, Doerte W.; Kelling, Katharina; Hornemann, Amadeus; Bohlmann, Michael K.

doi:10.1007/s00404-011-2059-7

Cited by 5 publications

(4 citation statements)

References 63 publications

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“…Similar reports from developed countries [20] have indicated that there is no serious health-related morbidities or malignancies following exposure to chemotherapy during the second and third trimesters of pregnancy. In view of the increasing incidence of malignant disease diagnosed during pregnancy, clinical guidelines and algorithms have recently been established for diagnosis and therapy [21,22]. More studies are needed to assess the well-being of the expectant mother against the well-being of the unborn neonate in these ethically and scientiWcally challenging situations.…”

Section: Discussionmentioning

confidence: 99%

Cancer during pregnancy: perinatal outcome after in utero exposure to chemotherapy

Abdel-Hady

Hemida

Gamal

et al. 2012

Arch Gynecol Obstet

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Section: Discussionmentioning

confidence: 99%

Cancer during pregnancy: perinatal outcome after in utero exposure to chemotherapy

Abdel-Hady

Hemida

Gamal

et al. 2012

Arch Gynecol Obstet

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“…Standard approach for breast cancer might not be suitable during pregnancy [32], since clinical experience of breast cancer in pregnant women is limited, making management decisions inevitably more complicated [12,33]. An adjustment in usual management and a modification of diagnostic methods, therapeutic tools and options is needed [33], in order to avoid possible risk to the fetus [12].…”

Section: Diagnosis Of Pabcmentioning

confidence: 99%

“…An adjustment in usual management and a modification of diagnostic methods, therapeutic tools and options is needed [33], in order to avoid possible risk to the fetus [12]. Diagnosis of PABC is based on clinical examination, imaging and histology, simi-lar to non-pregnant women [12], however, it is more difficult due to the major hormone-induced changes that occur in breast tissue, resulting in a delayed, later stage presentation, with more metastases and poorer prognosis [4,12,24,32,34]. This is of critical importance in the management of PABC.…”

Section: Diagnosis Of Pabcmentioning

confidence: 99%

Pregnancy associated breast cancer (PABC): Aspects in diagnosis

Kakoulidis¹,

Σκάγιας²,

Politi³

2015

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Diagnosis of a clinical entity like pregnancy associated breast cancer (PABC) is as demanding and challenging as its rarity. Increasing incidence and controversy that exists in the literature upon prognosis, tumor aggressiveness and underlying mechanisms, highlight the importance of optimizing the diagnostic strategy in women with PABC. Adjustment of standard approach for breast cancer by modifying management methods and options plays key role in decision making. Knowledge of diagnostic modalities and their limitations, in accordance with awareness of physiologic hormone-induced changes of pregnancy and lactation, is the fundamental method of diagnosis in PABC. Thorough triple assessment (history/clinical examination, imaging and cytology/histology) enforces healthcare providers with all essential tools to avoid detrimental delay in diagnosis and to confront with their own hesitation to take action due to limited experience of the disease.

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“…Усе це призводить до майбутніх мультифакторіальних розладів здоров'я молодих жінок: розладів травної системи -у 22,6 %, а за даними деяких авторів, до 70 %; сечостатевої системи -у 15,0 %, органів дихання -14,8 %, системи кровообігу -13,9 % та опорно-рухової системи -22 % [39,40].…”

Section: підліткова менструальна дисфункція як маркер майбутніх розла...unclassified

Adolescent menstrual dysfunction as a marker of future disorders of women’s sexual and reproductive health

Semenyuk

Pankiv

Chernukha

et al. 2023

Mìžnarodnij endokrinologìčnij žurnal

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The literature review considers the health state in women of early reproductive age. This is related to the common factors of formation that arise in adolescence, and are clinically manifested in the reproductive age. Disorders of the reproductive system functioning in puberty often lead to infertility, obstetric complications and perinatal losses. Ghrelin is a factor in the pathogenesis of functional amenorrhea during weight loss. Its concentration has a negative correlation with body mass index and androgen levels in the female body. Excessive physical exertion is one of the causes of functional amenorrhea, because this pathology is associated with increased levels of β-endorphin and ghrelin, as well as extremely low concentrations of leptin. Recent researches have demonstrated the importance of hidden genetic reproductive polymorphisms in women with the above-mentioned risk factors for amenorrhea for the future impairment of fertility. That is why women without genetic polymorphisms are able to restore both menstrual and reproductive functions after eliminating the influence of risk factors. However, in patients with some types of genetic mutations, amenorrhea persists despite the normalization of body weight, disappearance of stress and/or reduction of physical exertion. Under conditions of war in Ukraine, there is an increase in the frequency of hypothalamic dysfunctions in women of active reproductive age with a decrease in body weight against the background of stress, head injuries, which gives the problem an extreme acuteness and urgency. An example of a clinical manifestation of functional gonadotropin insufficiency is a menstrual disorder with the formation of secondary amenorrhea in 35 % of cases. Stress-induced (psychogenic) amenorrhea is one of the most common causes of functional gonadotropin deficiency. Menstrual and sexual female dysfunction is a multifactorial disorder that impairs women’s fertility, leads to pregnancy loss, infertility, and abnormal gestation. Due to dysmetabolic disorders, violations of ovarian steroidogenesis with hypothalamic-pituitary imbalance, this problem becomes multidisciplinary.

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Cancer in pregnancy. Part II: treatment options of breast and other non-gynecological malignancies

Abstract: The prognosis of the malignancy and the patient's informed consent must be taken into consideration when the well-being of the expectant mother is weighed against the well-being of the unborn child in case of maternal cancer during pregnancy.

Cited by 5 publications

References 63 publications

Cancer during pregnancy: perinatal outcome after in utero exposure to chemotherapy

Cancer during pregnancy: perinatal outcome after in utero exposure to chemotherapy

Pregnancy associated breast cancer (PABC): Aspects in diagnosis

Adolescent menstrual dysfunction as a marker of future disorders of women’s sexual and reproductive health

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