Cancer Exosomes for Early Pancreatic Cancer Diagnosis and Role in Metastasis

Korc, Murray; McElyea, Samantha Deitz

doi:10.1007/978-1-4939-6631-8_67-1

Cited by 2 publications

(3 citation statements)

References 81 publications

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“…The tumor volume contains not just highly diverse cancerous cells groups; it also includes several essential and infiltrating host cells, secreted factors, and extracellular matrix proteins, generally referred to as the tumor microenvironment [86]. It is widely known that the tumor microenvironment is made up of macrophages, dendritic cells, T cells, endothelial cells and fibroblasts, proteases, cytokines, ECM play a significant role in tumor evolution and metastasis in different types of cancer especially in pancreatic cancer [87].…”

Section: Mir-550mentioning

confidence: 99%

The involvement of exosomes in the diagnosis and treatment of pancreatic cancer

et al. 2020

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At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that is based on different kinds of genes. Exosomes are extracellular vesicles containing microRNAs (miRNAs), messenger RNA (mRNA), and proteins, they act as the most prominent mediator of intercellular communication, and they regulate, instruct, and re-educate their surrounding microenvironment and target specific organs. Due to accumulative evidence proved that exosomes are involved in metastasis, cell proliferation, EMT, angiogenesis, and TME of pancreatic cancer, exosomes are crucial potential candidates to detect pancreatic cancer early. This review aims to convey the current understanding of the main functions employed by exosomes in early diagnosis and treatment of pancreatic cancer.

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Section: Mir-550mentioning

confidence: 99%

The involvement of exosomes in the diagnosis and treatment of pancreatic cancer

et al. 2020

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“…In another murine study, BMSC-derived engineered exosome (iExosomes) administration did not produce any toxicity and adverse immune reactions (Mendt et al, 2018). The engineered approaches for EVs mentioned in the present work suggest that EVs are a safe and non-toxic method for delivering cargo compared to cationic lipids, viral vectors, and polymer-based methods (Mendt et al, 2018). Moreover, long-term pre-clinical and clinical studies are needed to further evaluate the toxicological and immunological profile of engineered EVs (Table 2).…”

Section: Safety and Toxicology Considerations Of Exosomesmentioning

confidence: 96%

“…In one study, C57BL/6 mice were given EVs for 3 weeks via intravenous and intraperitoneal administration, and no toxicity was observed with slight changes in expression of immune markers (Zhu et al, 2017). In another murine study, BMSC-derived engineered exosome (iExosomes) administration did not produce any toxicity and adverse immune reactions (Mendt et al, 2018). The engineered approaches for EVs mentioned in the present work suggest that EVs are a safe and non-toxic method for delivering cargo compared to cationic lipids, viral vectors, and polymer-based methods (Mendt et al, 2018).…”

Section: Safety and Toxicology Considerations Of Exosomesmentioning

confidence: 99%

Mesenchymal Stromal Cell-Derived Tailored Exosomes Treat Bacteria-Associated Diabetes Foot Ulcers: A Customized Approach From Bench to Bed

et al. 2021

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Exosomes are nano-vesicles of endosomal origin inherited with characteristics of drug delivery and cargo loading. Exosomes offer a diverse range of opportunities that can be exploited in the treatment of various diseases post-functionalization. This membrane engineering is recently being used in the management of bacteria-associated diabetic foot ulcers (DFUs). Diabetes mellitus (DM) is among the most crippling disease of society with a large share of its imposing economic burden. DM in a chronic state is associated with the development of micro- and macrovascular complications. DFU is among the diabetic microvascular complications with the consequent occurrence of diabetic peripheral neuropathy. Mesenchymal stromal cell (MSC)-derived exosomes post-tailoring hold promise to accelerate the diabetic wound repair in DFU associated with bacterial inhabitant. These exosomes promote the antibacterial properties with regenerative activity by loading bioactive molecules like growth factors, nucleic acids, and proteins, and non-bioactive substances like antibiotics. Functionalization of MSC-derived exosomes is mediated by various physical, chemical, and biological processes that effectively load the desired cargo into the exosomes for targeted delivery at specific bacterial DFUs and wound. The present study focused on the application of the cargo-loaded exosomes in the treatment of DFU and also emphasizes the different approaches for loading the desired cargo/drug inside exosomes. However, more studies and clinical trials are needed in the domain to explore this membrane engineering.

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Cancer Exosomes for Early Pancreatic Cancer Diagnosis and Role in Metastasis

Cited by 2 publications

References 81 publications

The involvement of exosomes in the diagnosis and treatment of pancreatic cancer

The involvement of exosomes in the diagnosis and treatment of pancreatic cancer

Mesenchymal Stromal Cell-Derived Tailored Exosomes Treat Bacteria-Associated Diabetes Foot Ulcers: A Customized Approach From Bench to Bed

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