Cancer Exosomes for Early Pancreatic Cancer Diagnosis and Role in Metastasis

Korc, Murray; McElyea, Samantha Deitz

doi:10.1007/978-1-4939-7193-0_67

Cited by 1 publication

(1 citation statement)

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“…The tumor volume contains not just highly diverse cancerous cells groups; it also includes several essential and infiltrating host cells, secreted factors, and extracellular matrix proteins, generally referred to as the tumor microenvironment [ 86 ]. It is widely known that the tumor microenvironment is made up of macrophages, dendritic cells, T cells, endothelial cells and fibroblasts, proteases, cytokines, ECM play a significant role in tumor evolution and metastasis in different types of cancer especially in pancreatic cancer [ 87 ].…”

Section: Leading Significant Clinically Relevant Roles Of Exosomes Inmentioning

confidence: 99%

The involvement of exosomes in the diagnosis and treatment of pancreatic cancer

et al. 2020

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At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and pancreatic cancer growth is a complex biological process that is based on different kinds of genes. Exosomes are extracellular vesicles containing microRNAs (miRNAs), messenger RNA (mRNA), and proteins, they act as the most prominent mediator of intercellular communication, and they regulate, instruct, and re-educate their surrounding microenvironment and target specific organs. Due to accumulative evidence proved that exosomes are involved in metastasis, cell proliferation, EMT, angiogenesis, and TME of pancreatic cancer, exosomes are crucial potential candidates to detect pancreatic cancer early. This review aims to convey the current understanding of the main functions employed by exosomes in early diagnosis and treatment of pancreatic cancer.

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Section: Leading Significant Clinically Relevant Roles Of Exosomes Inmentioning

confidence: 99%