Cancer, Erythema Annulare Centrifugum, Autoimmunity

Subacute Lupus erythematosus-like Gyrate Erythema

“…Gyrate erythemas have been observed frequently in association with internal m a lignant tumors [Dijk, 1961;Lazar, 1963;Summerly, 1964;Thomson and Stankler, 1970;Blanc and Kienzler, 1982], Ackerman [1978] divided these erythemas into a super ficial and a deep type, based on histopathological criteria. Reviewing the literature [Ormsby, 1933;Ellis and Friedman, 1954;Irgang, 1957], much confusion has emerged in differentiating gyrate erythemas from subacute cutaneous lupus erythematosus (SCLE).…”

Eruption Resembling Erythema gyratum repens in Linear IgA Dermatosis

“…The presence of EGR-like eruptions during bullous dermatoses might reflect similar autoimmune mechanisms [1J. Indeed autoimmunity has also been reported in erythema figuratum associated with carcinomatosis [17], EGR has been reported also in association with CREST syndrome [18], and the manifesta tions of cutaneous lupus erythematosus may be identical to those of EGR [19][20][21], Moreover, there is evidence of acti vated immunological mechanisms in EGR [22]: in particu lar, IgG and C3 deposits at the basement membrane zone have been reported [22,23]. Therefore, it has been hypoth esized that EGR is an autoimmune phenomenon triggered by tumor or other kinds of antigens [24], However, the coexistence of figured erythemas during the course of auto immune disorders, such as bullous pemphigoid, eosino philic spongiosis, linear IgA dermatosis and lupus erythe matosus, remains to be explained.…”

Annually recurring erythema annulare centrifugum: a case report

“…The etiology and pathogenesis are unknown [4]. It is believed that EAC represents a cutaneous manifestation of a type IV hypersensitivity reaction to different causes and underlying systemic diseases, including: food allergy, arthropod bites, drug reactions (finasteride, chloroquine, hydroxychloroquine, hydrochlorothiazide, piroxicam, etizolam, cimetidine, penicillin, salicylates, spironolactone, gold sodium thiomalate, amitriptyline, ustekinumab, rituximab), infections disease (bacterial, viral, parasitic, fungal, mycobacterial), endocrine and immunological disorders (menstrual cycle, Graves disease, Hashimoto thyroiditis, Sjögren syndrome, autoimmune progesterone dermatitis), hematological and other neoplastic disorders (Hodgkin lymphoma, non-Hodgkin lymphoma, acute leukemia, histiocytosis, multiple myeloma, nasopharyngeal carcinoma, prostatic adenocarcinoma, breast carcinoma, ovarian carcinoma) [5–10]. Treatment and eradication of the underlying disease often resolves EAC.…”