Cancer: Diet in Cancer Prevention

Tsuji, Petra A.; Galinn, Sarah E.; Hartman, Johan

doi:10.1016/b978-0-12-384947-2.00108-2

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…Being aware of the microbiota metabolism of xenobiotics, many scientific teams include two of the most commonly available metabolites, enterolactone and enterodiol, in their studies. [93][94][95][96] However, most in vivo and in vitro studies are based on a synthetic metabolite consisting of a mixture of two isomers, R/S-(+/-)-enterolactone. Considering that the colon metabolism of lignans leads to the production of a mixture of enantiomers in different ratios depending on the structure of parental compounds, 97,98 the question of their stereochemistry should be addressed in in vitro and in vivo studies.…”

Section: Lignans-enterolactone and Enterodiolmentioning

confidence: 99%

Dietary polyphenol and microbiota interactions in the context of prostate health

Piwowarski

Stanisławska

Granica

2021

Annals of the New York Academy of Sciences

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Recent data strongly indicate a relationship between prostate health and gut microbiota, in which composition and physiological function strictly depend on dietary patterns. The bidirectional interplay of foods containing polyphenols, such as ellagitannins, condensed tannins, lignans, isoflavones, and prenylated flavonoids with human gut microbiota, has been proven to contribute to their impact on prostate health. Considering the attributed role of dietary polyphenols in the prevention of prostate diseases, this paper aims to critically review the studies concerning the influence of polyphenols' postbiotic metabolites on processes associated with the pathophysiology of prostate diseases. Clinical, in vivo, and in vitro studies on polyphenols have been juxtaposed with the current knowledge regarding their pharmacokinetics, microbial metabolism, and potential interactions with microbiota harboring different niches of the human organism. Directions of future research on dietary polyphenols regarding their interaction with microbiota and prostate health have been indicated.

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Section: Lignans-enterolactone and Enterodiolmentioning

confidence: 99%

Dietary polyphenol and microbiota interactions in the context of prostate health

Piwowarski

Stanisławska

Granica

2021

Annals of the New York Academy of Sciences

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“…Phytochemicals are plant‐derived metabolites found in a wide range of fruits, vegetables, and herbs (Tsuji, Galinn, & Hartman, 2016). Due to favorable safety profiles and bioavailability, polyphenols, alkaloids, terpenoids, and organosulfur compounds are well‐known phytochemical groups with excellent health‐promoting effects such as anticancer properties and have been used for years to prevent or treat different types of cancers based on traditional medicinal practices (Abbasi et al, 2018; Budisan et al, 2017; Chiou, Li, Ho, & Pan, 2018; Izzo, Hoon‐Kim, Radhakrishnan, & Williamson, 2016; Kaur et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Phytochemicals are plant-derived metabolites found in a wide range of fruits, vegetables, and herbs (Tsuji, Galinn, & Hartman, 2016).…”

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confidence: 99%

Phytochemicals mediated modulation of microRNAs and long non‐coding RNAs in cancer prevention and therapy

Ruiz‐Manriquez

Estrada-Meza

Benavides‐Aguilar

et al. 2021

Phytotherapy Research

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MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are two main categories of noncoding RNAs (ncRNAs) that can influence essential biological functions in various ways, as well as their expression and function are tightly regulated in physiological homeostasis. Additionally, the dysregulation of these ncRNAs seems to be crucial to the pathogenesis of human diseases. The latest findings indicate that ncRNAs execute vital roles in cancer initiation and progression, and the cancer phenotype can be reversed by modulating their expression. Available scientific discoveries suggest that phytochemicals such as polyphenols, alkaloids, terpenoids, and organosulfur compounds can significantly modulate multiple cancer-associated miRNAs and lncRNAs, thereby inhibiting cancer initiation and development. However, despite promising outcomes of experimental research, only a few clinical trials are currently being conducted to evaluate the therapeutic effectiveness of these compounds. Nevertheless, understanding phytochemical-mediated ncRNA regulation in cancer and the underlying molecular mechanisms on tumor pathophysiology can aid in the development of novel therapeutic strategies to combat this deadly disease.

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“…When nitrite enters the stomach, the nitrosation reaction occurs under the acidic condition to convert amines or amides to N-nitroso compounds. Thus, long-term exposure of these chemicals may lead to gastric cancer (22,23,(77)(78)(79)(80) .…”

Section: Nitrite and Gastric Cancermentioning

confidence: 99%

Effect of bitter gourd extracts on the mutagenicity of 1-aminopyrene reacted with nitrite using ames test

Panpasuk

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This study was conducted to investigate the mutagenic activity of raw and cooked bitter gourd (Momordica charantia) including raw fruit extract (RW), blanching water (BW), hot water extract from blanched fruit (HB), stir-fried fruit extract (SF), and stir-fried fruit (pre-squeezed with salt) extract (SS). In addition, the effects of extracts in modifying the mutagenic activity of mutagen freshly prepared by the reaction between 1-aminopyrene and sodium nitrite and the effects when adding each extract at the beginning of the same reaction using Ames test on Salmonella typhimurium strains TA98 and TA100 without enzymatic activation were also determined. The data for mutagenic activity were expressed as a number of histidine revertant colonies/plate and expressed as percentage of modification for mutagenic modification effect.�The results showed that all extracts had no direct mutagenic activity either with or without sodium nitrite treatment on both tester strains. The effect of bitter gourd extracts in modifying the mutagenic activity of newly formed mutagen showed that RW had the mutagenic enhancing effect on S. typhimurium strain TA98 (%enhancement = 9.54-147.62). However, there was no mutagenic enhancing effect on S. typhimurium strain TA100 (%enhancement <20%). For cooked bitter gourd extract, it was found that the percentage of mutagenic enhancement of BW (116.12%-338.06% and 74.93%-109.95% for TA98 and TA100, respectively) tended to be higher than that of HB on both stains (42.61%-140.85% and 8.59%-77.29% for TA98 and TA100, respectively). In addition, the similar trend was found from the results of the stir-fried bitter gourd. SS showed lower enhancing effect on the mutagenicity of newly formed mutagen than SF.�The results of the effect of bitter gourd extracts added before starting the mutagen forming reaction showed that all extracts exhibited enhancing effects on S. typhimurium strains TA98 and TA100. In addition, the percentage of mutagenic enhancement of BW (74.21%-348.69% and 13.10%-74.97% for TA98 and TA100, respectively) showed a higher trend than that of HB on both strains of S. typhimurium (37.19%-57.46% and 3.54%-34.66% for TA98 and TA100, respectively). SS showed lower values of the percentage of mutagenic enhancement when comparing with SF on S. typhimurium strain TA98. However, when tested with S. typhimurium strain TA100, it was found that the results were different. These values obtained from SS (19.06%-88.48%) tend to be higher than that of SF (2.90%-57.09%).�The present study provides the information that raw and cooked bitter gourd are safe for consumption in consideration of mutagenicity. In the case of cooking, the fruit should be pretreatment first. These pretreatment methods such as blanching before boiling or squeezing with salt before stir frying not only reduce the bitter taste of this fruit, but may also reduce the risk of promoting mutagenic effects of some mutagens that may be contaminated in food.

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Cancer: Diet in Cancer Prevention

Cited by 3 publications

References 5 publications

Dietary polyphenol and microbiota interactions in the context of prostate health

Dietary polyphenol and microbiota interactions in the context of prostate health

Phytochemicals mediated modulation of microRNAs and long non‐coding RNAs in cancer prevention and therapy

Effect of bitter gourd extracts on the mutagenicity of 1-aminopyrene reacted with nitrite using ames test

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