Abstract:Biomarkers can potentially help in the detection and prognosis of diseases such as cancer, its recurrence, predicting response to therapy, and monitoring of response during and/or after treatment. Endogenous tumor blood biomarkers suffer from low concentrations that are not distinguishable from background noise and, if identified, the localization of the biomarker production site is not known. The use of exogenously introduced or artificial biomarkers can eliminate these issues. In this study, we show that can… Show more
“…Endogenous tumor blood biomarkers suffer from low concentration and from the fact that it is not possible to define the localization of biomarker production. The authors proposed an approach with the use of exogenous Sec-miR to try to solve these problems by introducing it into the cells via a non-viral episomal microcircle [ 8 ].…”
“…Endogenous tumor blood biomarkers suffer from low concentration and from the fact that it is not possible to define the localization of biomarker production. The authors proposed an approach with the use of exogenous Sec-miR to try to solve these problems by introducing it into the cells via a non-viral episomal microcircle [ 8 ].…”
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